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5.3.2.6: 2-hydroxymuconate tautomerase

This is an abbreviated version!
For detailed information about 2-hydroxymuconate tautomerase, go to the full flat file.

Word Map on EC 5.3.2.6

Reaction

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate
=
(3E)-2-oxohex-3-enedioate

Synonyms

4-OT, 4-oxalocrotonate tautomerase, 4-oxalocrotonate tautomerase I, 4-oxalocrotonate tautomerase II, 4OT, AfDmpI, D-4-oxalocrotonate tautomerase, HpDmpI, L-4-oxalocrotonate tautomerase, OCA, PRAC, SAR1376, TomN, xylH, YwhB

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.2 Interconverting keto- and enol-groups
                5.3.2.6 2-hydroxymuconate tautomerase

Inhibitors

Inhibitors on EC 5.3.2.6 - 2-hydroxymuconate tautomerase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-2-fluoro-2,4-pentadienoate
-
-
(2E)-fluoromuconate
-
a dicarboxylate competitive inhibitor, shows substoichiometric binding to 3 +/- 1 sites per hexamer
(2E,4Z)-2-bromo-5-hydroxyhexa-2,4-dienedioic acid
(2E,4Z)-2-chloro-5-hydroxyhexa-2,4-dienedioic acid
(2E,4Z)-2-fluoro-5-hydroxyhexa-2,4-dienedioic acid
(2Z)-2-fluoro-2,4-pentadienoate
-
-
(2Z,4E)-5-bromo-2-hydroxypenta-2,4-dienoic acid
(2Z,4E)-5-chloro-2-hydroxypenta-2,4-dienoic acid
(2Z,4E)-5-fluoro-2-hydroxypenta-2,4-dienoic acid
(3Z)-5-bromo-2-oxopent-3-enoic acid
(3Z)-5-chloro-2-oxopent-3-enoic acid
(3Z)-5-fluoro-2-oxopent-3-enoic acid
2-Oxo-3-pentynoate
3-Bromopyruvate
-
a active-site-directed irreversible inhibitor, modification of three active sites per hexamer abolishes essentially all activity of the hexamer, pH dependence of inactivation
additional information
-
although 4-OT exhibits no structural asymmetry either by X-ray or by NMR, inactivation by two affinity labels shows half-site stoichiometry
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