5.3.1.8: mannose-6-phosphate isomerase

This is an abbreviated version!
For detailed information about mannose-6-phosphate isomerase, go to the full flat file.

Reaction

Synonyms

BceA, BceAJ, becA, CHLNCDRAFT_139231, D-mannose-6-phosphate ketol-isomerase, GTMpi, Isomerase, mannose phosphate, KB1_0553, M6PI, ManA, Mannose phosphate isomerase, mannose-6-phosphate isomerase, MPI, Os01g0127900, Os09g0389000, PH0925, Phosphohexoisomerase, Phosphohexomutase, Phosphomannoisomerase, Phosphomannose isomerase, phosphomannose-isomerase, Phosphphexomutase, PMI, PMI/GMP, Pmi1, PMI2, PslB, type I phosphomannose isomerase, type I PMI

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.1 Interconverting aldoses and ketoses, and related compounds

                5.3.1.8 mannose-6-phosphate isomerase

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Results	in table
6	Activating Compound
25929	AA Sequence
23	Application
1	CAS Registry Number
38	Cloned(Commentary)
10	Crystallization (Commentary)
241	Disease/ Diagnostics
18	General Information
1	General Stability
10	IC50 Value
139	Inhibitors
30	kcat/KM [mM/s]
18	Ki Value [mM]
80	KM Value [mM]
91	Metals/Ions
46	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
130	Organism
17	Pathway
27	PDB ID
23	pH Optimum
9	pH Range
4	pH Stability
3	pI Value
103	Protein Variants
17	Purification (Commentary)
6	Reaction
4	Reaction Type
124	Reference
33	Source Tissue
85	Specific Activity [micromol/min/mg]
1	Storage Stability
165	Substrates and Products (Substrate)
34	Subunits
83	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
3	Temperature Range [°C]
24	Temperature Stability [°C]
44	Turnover Number [1/s]

KI Value

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KI Value on EC 5.3.1.8 - mannose-6-phosphate isomerase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.162

5-deoxy-5-malonyl-D-arabinonohydroxamic acid

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

727158

0.0006 - 0.002

5-phospho-D-arabinonhydrazide

3 entries

0.000041 - 0.0008

5-phospho-D-arabinonohydroxamic acid

5 entries

0.0105 - 0.115

6-deoxy-6-dicarboxymethyl-D-mannose

2 entries

0.11 - 58

6-phosphogluconate

3 entries

0.035 - 0.164

erythrose 4-phosphate

2 entries

0.0014

erythrose-4-phosphate

Pyrobaculum aerophilum

-

pH 7.4, 50°C

661679

10

N,2,3,4,5-pentahydroxypentanamide

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

727158

0.0006

5-phospho-D-arabinonhydrazide

Homo sapiens

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

0.0017

5-phospho-D-arabinonhydrazide

Candida albicans

P34948

pH not specified in the publication, temperature not specified in the publication

747781

0.002

5-phospho-D-arabinonhydrazide

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

0.000041

5-phospho-D-arabinonohydroxamic acid

Homo sapiens

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

0.00008

5-phospho-D-arabinonohydroxamic acid

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

0.000086

5-phospho-D-arabinonohydroxamic acid

Saccharomyces cerevisiae

-

pH 7.1, 25°C

661119

0.000137

5-phospho-D-arabinonohydroxamic acid

Pseudomonas aeruginosa

-

pH 7.1, 25°C

661119

0.0008

5-phospho-D-arabinonohydroxamic acid

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

727158

0.0105

6-deoxy-6-dicarboxymethyl-D-mannose

Saccharomyces cerevisiae

-

pH 7.1, 25°C, recombinant enzyme

702663

0.115

6-deoxy-6-dicarboxymethyl-D-mannose

Escherichia coli

-

pH 7.1, 25°C, recombinant enzyme

702663

0.11

6-phosphogluconate

Pyrobaculum aerophilum

-

pH 7.4, 50°C

661679

2 - 10

6-phosphogluconate

Thermoplasma acidophilum

Q9HIC2

80°C, pH 7.4

662220

58

6-phosphogluconate

Aeropyrum pernix

Q9YE01

80°C, pH 7.4

662220

0.035

erythrose 4-phosphate

Aeropyrum pernix

Q9YE01

80°C, pH 7.4

662220

0.164

erythrose 4-phosphate

Thermoplasma acidophilum

Q9HIC2

80°C, pH 7.4

662220