5.3.1.8: mannose-6-phosphate isomerase
This is an abbreviated version!
For detailed information about mannose-6-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.8
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5.3.1.8
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phosphomannomutase
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gdp-mannose
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pyrophosphorylase
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phosphoglucomutase
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fructose-6-phosphate
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phosphoglucose
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enteropathy
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carbohydrate-deficient
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viannia
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allozyme
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braziliensis
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chlorophenol
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mannose-containing
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man-6-p
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phosphoglucoisomerase
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biolistic
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protein-losing
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l-ribose
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peruviana
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synthesis
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thermodenitrificans
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guyanensis
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biotechnology
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agriculture
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pharmacology
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analysis
- 5.3.1.8
- phosphomannomutase
- gdp-mannose
-
pyrophosphorylase
- phosphoglucomutase
- fructose-6-phosphate
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phosphoglucose
- enteropathy
-
carbohydrate-deficient
- viannia
-
allozyme
- braziliensis
- chlorophenol
-
mannose-containing
-
man-6-p
- phosphoglucoisomerase
-
biolistic
-
protein-losing
- l-ribose
- peruviana
- synthesis
- thermodenitrificans
-
guyanensis
- biotechnology
- agriculture
- pharmacology
- analysis
Reaction
Synonyms
BceA, BceAJ, becA, CHLNCDRAFT_139231, D-mannose-6-phosphate ketol-isomerase, GTMpi, Isomerase, mannose phosphate, KB1_0553, M6PI, ManA, Mannose phosphate isomerase, mannose-6-phosphate isomerase, MPI, Os01g0127900, Os09g0389000, PH0925, Phosphohexoisomerase, Phosphohexomutase, Phosphomannoisomerase, Phosphomannose isomerase, phosphomannose-isomerase, Phosphphexomutase, PMI, PMI/GMP, Pmi1, PMI2, PslB, type I phosphomannose isomerase, type I PMI
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Application
Application on EC 5.3.1.8 - mannose-6-phosphate isomerase
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agriculture
analysis
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development and optimization of a transformation method using the phosphomannose-isomerase gene pmi as a selectable marker for Brassica napus transformation via Agrobacterium tumefaciens, overview
biotechnology
pharmacology
synthesis
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expression system based on phosphomannose-isomerase gene as a selectable marker in Agrobacterium-based transformation and mannose as the selective agent for the transformation of apple. Selection of leaf explants on medium supplemented with mannose and sorbitol, integration of transgenes in the apple genome and their activity are confirmed
agriculture
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non-antibiotic selection system based on heterologous expression of enzyme in Brassica rapa via Agrobacterium tumefaciens infection and screening for cotyledon explants that survive in media containing more than 5 g per l mannose. Presence of gene does not inhibit the growth of transgenic plants
agriculture
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selection system for onion using Agrobacterium-based transformation with phosphomannose isomerase as selectable marker. Selection depends on detoxification of mannose 6-phosphate by conversion to fructose 6-phosphate in six-week-old embryonic calli. Transformation rates of 23-27% are obtained
agriculture
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use of enzyme as selectable marker for Agrobacterium-medíated transformation of Linum usitatissimum. Transgenic flax plants able to root on mannose-containing medium are obtained on a combination of 20 g per l sucrose and 10 g per l mannose. Mean transformation efficacy is 3.6%
agriculture
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use of enzyme as selectable marker in Agrobacterium-based expression of transgenes in Brassica rapa. Supplementation of media with 7 g per l mannose and 2% sucrose provides best conditions for the selection of transformed plants. Transformation rates of 1.4-3% are obtained
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effective use of enzyme gene as selectable marker gene for transformation of embryogenic calli of Carica papaya
biotechnology
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selection system for transformation of onion using enzyme gene and Agrobacterium. Transformation rates are around 25%
biotechnology
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use of enzyme as selectable marker for transformation of Oriza sativa immature embryo via Agrobacterium
biotechnology
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use of enzyme gene as selectable marker for transformation of Penniseum glaucum. Enzyme gene is a superior selectable marker for improving transformation efficiencies when compared to antibiotic or herbicide selectable marker genes
biotechnology
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the pmi/mannose selection system is highly efficient for producing transgenic Oncidium Gower Ramsey without using antibiotics or herbicides
biotechnology
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the pmi/mannose selection system is highly efficient for producing transgenic Oncidium Gower Ramsey without using antibiotics or herbicides
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absence of mannose-6-phosphate isomerase causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs
pharmacology
the enzyme may be a target for anti-Leishmania drug development
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inactivation of the manA gene encoding phosphomannose isomerase results in production of amphotericins and their aglycones, 8-deoxyamphoteronolides. A double mutant lacking the phosphomannose isomerase and phosphomannomutase genes produces 8-deoxyamphoteronolides in good yields along with trace levels of glycosylated amphotericins
synthesis
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L-ribose production of the enzyme in a coupled assay system with L-arabinose isomerase, EC 5.3.1.4, in recombinant Escherichia coli ER2566, AI/MPI ratio, 1:2.5, method optimization. L-Ribose is a potential starting material for the synthesis of many L-nucleoside-based pharmaceutical compounds
synthesis
mannose-6-phosphate isomerase from Bacillus subtilis is applied for the production of L-ribose by direct isomerization of L-ribulose
synthesis
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development of a agrobacterium-mediated Jatropha curcas transformation procedure using mannose 6-phosphate isomerase as a selectable marker. The transformation efficiency with mannose selection is twice that of kanamycin selection
synthesis
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production of ribose by immobilized recombinant Escherichia coli cells expressing the L-arabinose isomerase gene and mannose-6-phosphate isomerase mutant W17Q/N90A/L129F. The immobilized cells produce 99 g/l L-ribose from 300 g/l L-arabinose in 3 h at pH 7.5 and 60°C in the presence of 1 mM Co2+, with a conversion yield of 33% (w/w) and a productivity of 33 g/l/h
synthesis
Q6H5C7, Q9FTR6
use as a selectable marker gene for transformation of Oryza sativa. In both Indica and Japonica subspecies, PMI expression can select and produce transgenic plants in a pattern similar to that of Escherichia coli PMI. The transgenic plants exhibit an accumulation of plant PMI transcripts and enhancement of the in vivo PMI activity. A gene of interest is successfully transformed into rice using the plant PMI as selectable marker gene
synthesis
use as a selectable marker gene for transformation of Oryza sativa. In both Indica and Japonica subspecies, PMI expression can select and produce transgenic plants in a pattern similar to that of Escherichia coli PMI. The transgenic plants exhibit an accumulation of plant PMI transcripts and enhancement of the in vivo PMI activity. A gene of interest is successfully transformed into rice using the plant PMI as selectable marker gene
synthesis
use of PMI gene as a selctable marker for plant transformation. A codon optimized nucleotide sequence for use in Oryza sativa leads to higher transformation frequency (54.5%) and single copy rate (44.5%)