5.3.1.6: ribose-5-phosphate isomerase
This is an abbreviated version!
For detailed information about ribose-5-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.6
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5.3.1.6
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indentation
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ribulose-5-phosphate
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clasp
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transaldolase
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calvin
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phosphoribulokinase
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denture
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peri-implantitis
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abut
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d-allose
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periapical
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endodontic
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d-psicose
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3-epimerase
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rri
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synthesis
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medicine
- 5.3.1.6
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indentation
- ribulose-5-phosphate
- clasp
- transaldolase
-
calvin
- phosphoribulokinase
-
denture
- peri-implantitis
-
abut
- d-allose
-
periapical
-
endodontic
- d-psicose
-
3-epimerase
- rri
- synthesis
- medicine
Reaction
Synonyms
5-phosphate ketol-isomerase, 5-Phosphoribose isomerase, CTRPI, CTRpiB, D-Ribose 5-phosphate isomerase, D-ribose-5-phosphate isomerase, D-ribose-5-phosphate isomerase A, D-ribose-5-phosphate isomerase B, D-ribose-5-phosphate ketol-isomerase, D-xylose ketol-isomerase, EcRpiB, Isomerase, ribose phosphate, LINJ_28_2100, LMJF_28_1970, MJ1603, MtRpiB, Phosphopentoisomerase, Phosphopentose isomerase, Phosphoriboisomerase, ribose 5-phosphate isomerase A, Ribose phosphate isomerase, Ribose-5-P isomerase, ribose-5-phosphate isomerase, ribose-5-phosphate isomerase B, ribose-5-phosphate isomerase type B, Ribosephosphate isomerase A, Ribosephosphate isomerase B, RPI, RPI2 protein, RpiA, RpiB, SMU1234, SMU2142, Tc00.1047053509199.24, TM1080, type B ribose 5-phosphate isomerase, type B ribose-5-phosphate isomerase, type B Rpi
ECTree
5.3.1.6 ribose-5-phosphate isomeraseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 5.3.1.6 - ribose-5-phosphate isomerase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2R,3S)-3-hydroxy-1-(6-oxo-1,4,5,6-tetrahydropyridazine-3-carbonyl)pyrrolidine-2-carboxylic acid
inhibitor identified by in silico analysis, shows best docking score of -12.735 forming six hydrogen bonds and one salt bridge
4-deoxy-4-phosphonomethyl-D-erythronate
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stable and potent competitive inhibitor
Mn2+
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slight inhibition of enzyme form I and II, strong inhibition of enzyme form III
[(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl hydrogen sulfate
inhibitor identified by in silico analysis, second best hit with dock-ing score of -11.927 and is predict to make eight hydrogenbonds, two electrostatic interactions and one possible pi-pi interaction
5-deoxy-5-phospho-D-ribonohydroxamic acid
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competitive and selective inhibitor of type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis
5-phospho-D-ribonate
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competitive inhibitor of a Rpi, displays specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview
5-phospho-D-ribonate
very strong competitive inhibitor of a Rpi, specific inhibition of Mycobacterium tuberculosis RpiB versus Escherichia coli RpiB, inhibition kinetics, overview
arabinose 5-phosphate
RpiA binds arabinose 5-phosphate located at the opening of the active site, the sugar ring of the inhibitor interacts with the Asp4, Lys7, Ser30, Asp118, and Lys121 residues, the phosphate group of arabinose 5-phosphate interacts with two water molecules, W51 and W82, binding mode of inhibitor, overview
iodoacetate
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1.25 mM, 100% loss of ribosephosphate isomerase B, no effect on ribosephosphate isomerase A
N-(5-phospho-D-ribonoyl)-glycine
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poor inhibition with substrate D-ribose 5-phosphate, no inhibition with substrate D-allose 5-phosphate
Phenylmercuriacetate
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reversible by 0.02-10 mM 2-mercaptoethanol, and by 10 mM Cys
Phenylmercuriacetate
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reversible by 0.02-10 mM 2-mercaptoethanol, and by 10 mM Cys
Sodium mersalyl
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reversible by 2-mercaptoethanol, 0.02-10 mM, and by Cys, 10 mM
Sodium mersalyl
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reversible by 2-mercaptoethanol, 0.02-10 mM, and by Cys, 10 mM
Sodium salt of 2-(ethylmercurimercapto)-benzoxazole-5-carboxylic acid
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additional information
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enzyme is not affected by metal ions and not inhibited by EDTA
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additional information
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substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview
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additional information
substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview
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additional information
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substrate-derived enzyme inhibitor design and synthesis of analogues of the 6-carbon high-energy intermediate postulated for the D-allose 6-phosphate to D-allulose 6-phosphate isomerization reaction, overview
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