5.3.1.6: ribose-5-phosphate isomerase

This is an abbreviated version!
For detailed information about ribose-5-phosphate isomerase, go to the full flat file.

Reaction

Synonyms

5-phosphate ketol-isomerase, 5-Phosphoribose isomerase, CTRPI, CTRpiB, D-Ribose 5-phosphate isomerase, D-ribose-5-phosphate isomerase, D-ribose-5-phosphate isomerase A, D-ribose-5-phosphate isomerase B, D-ribose-5-phosphate ketol-isomerase, D-xylose ketol-isomerase, EcRpiB, Isomerase, ribose phosphate, LINJ_28_2100, LMJF_28_1970, MJ1603, MtRpiB, Phosphopentoisomerase, Phosphopentose isomerase, Phosphoriboisomerase, ribose 5-phosphate isomerase A, Ribose phosphate isomerase, Ribose-5-P isomerase, ribose-5-phosphate isomerase, ribose-5-phosphate isomerase B, ribose-5-phosphate isomerase type B, Ribosephosphate isomerase A, Ribosephosphate isomerase B, RPI, RPI2 protein, RpiA, RpiB, SMU1234, SMU2142, Tc00.1047053509199.24, TM1080, type B ribose 5-phosphate isomerase, type B ribose-5-phosphate isomerase, type B Rpi

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.1 Interconverting aldoses and ketoses, and related compounds

                5.3.1.6 ribose-5-phosphate isomerase

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Results	in table
8	Activating Compound
38859	AA Sequence
5	Application
1	CAS Registry Number
29	Cloned(Commentary)
22	Crystallization (Commentary)
291	Disease/ Diagnostics
10	General Information
8	General Stability
22	IC50 Value
114	Inhibitors
27	kcat/KM [mM/s]
27	Ki Value [mM]
87	KM Value [mM]
9	Localization
9	Metals/Ions
55	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
219	Organism
19	Pathway
133	PDB ID
22	pH Optimum
4	pH Range
2	pH Stability
6	pI Value
46	Protein Variants
29	Purification (Commentary)
1	Reaction
2	Reaction Type
101	Reference
33	Source Tissue
68	Specific Activity [micromol/min/mg]
7	Storage Stability
195	Substrates and Products (Substrate)
39	Subunits
108	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
19	Temperature Stability [°C]
66	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 5.3.1.6 - ribose-5-phosphate isomerase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5

4-phospho-D-erythronate

Trypanosoma cruzi

Q4CQE2

pH 8.4, 25°C

678047

0.7

4-phospho-D-erythronohydroxamic acid

Trypanosoma cruzi

Q4CQE2

pH 8.4, 25°C

678047

0.2 - 1.33

5-phospho-D-ribonamide

3 entries

0.031 - 1.31

5-phospho-D-ribonate

2 entries

0.17 - 0.62

5-phospho-D-ribonohydroxamic acid

3 entries

2

D-Allose 6-phosphate

Mycobacterium tuberculosis

P9WKD7

in 50 mM Tris-HCl, pH 7.5, at 37°C

693661

6.3

D-allulose 6-phosphate

Mycobacterium tuberculosis

P9WKD7

in 50 mM Tris-HCl, pH 7.5, at 37°C

693661

1.42 - 2

N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate

3 entries

0.57 - 9

N-(5-phospho-D-ribonoyl)-glycine

2 entries

1

N-(5-phospho-D-ribonoyl)-hydrazine

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.19 - 0.36

N-(5-phospho-D-ribonoyl)-methylamine

3 entries

additional information

additional information

2 entries

-

0.2

5-phospho-D-ribonamide

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.22

5-phospho-D-ribonamide

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

1.33

5-phospho-D-ribonamide

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate

703070

0.031

5-phospho-D-ribonate

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

1.31

5-phospho-D-ribonate

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.17

5-phospho-D-ribonohydroxamic acid

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.44

5-phospho-D-ribonohydroxamic acid

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.62

5-phospho-D-ribonohydroxamic acid

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate

703070

1.42

N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

1.6

N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate

703070

2

N-(5-phospho-D-ribonoyl)-gamma-aminobutanoate

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.57

N-(5-phospho-D-ribonoyl)-glycine

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

9

N-(5-phospho-D-ribonoyl)-glycine

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.19

N-(5-phospho-D-ribonoyl)-methylamine

Mycobacterium tuberculosis

P9WKD7

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

0.35

N-(5-phospho-D-ribonoyl)-methylamine

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-allose 5-phosphate

703070

0.36

N-(5-phospho-D-ribonoyl)-methylamine

Escherichia coli

-

pH 7.5, 37°C, RpiB, substrate is D-ribose 5-phosphate

703070

additional information

additional information

Trypanosoma cruzi

Q4CQE2

IC50 values of 5-phospho-D-ribonohydroxamic acid and 4-phospho-D-erythronhydrazide are above 10 mM

678047

-

additional information

additional information

Trypanosoma cruzi

-

IC50 values of 5-phospho-D-ribonohydroxamic acid and 4-phospho-D-erythronhydrazide are above 10 mM

678047

-