5.3.1.21: corticosteroid side-chain-isomerase

This is an abbreviated version!
For detailed information about corticosteroid side-chain-isomerase, go to the full flat file.

Reaction

Synonyms

11-deoxycorticosterone ketol-isomerase, Corticosteroid side chain isomerase, CSC isomerase, Isomerase, corticosteroid sidechain

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.1 Interconverting aldoses and ketoses, and related compounds

                5.3.1.21 corticosteroid side-chain-isomerase

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Results	in table
2	Activating Compound
1	CAS Registry Number
14	Inhibitors
2	KM Value [mM]
1	Localization
20	Metals/Ions
3	Molecular Weight [Da]
18	Organism
2	pH Optimum
1	Posttranslational Modification
3	Purification (Commentary)
2	Reaction
2	Reaction Type
18	Reference
27	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
21	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
1	Systematic Name
4	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 5.3.1.21 - corticosteroid side-chain-isomerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

18 entries

17alpha-Hydroxy-11-deoxycorticosterone

17alpha,20-Dihydroxy-3-oxopregn-4-en-21-al

Rattus norvegicus

-

-

2656

-

-

?

20beta-Hydroxy-3-oxopregn-4-en-21-al

20alpha-Hydroxy-3-oxopregn-4-en-21-al

Mesocricetus auratus

-

-

2653

-

2653

?

Corticosterone

11beta,20-Dihydroxy-3-oxopregn-4-en-21-al

Rattus norvegicus

-

-

2656

-

-

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Bos taurus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Canis lupus familiaris

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Cavia porcellus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Equus caballus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Gallus gallus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Homo sapiens

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mesocricetus auratus

-

-

2651

-

2651

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mesocricetus auratus

-

-

2657

-

2657

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mesocricetus auratus

-

the reversible interconversion of the ketol and aldol forms of the corticosteroid side chain is accompanied by epimerization at position 20 and 21

2653

-

2653

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mus musculus

-

-

2652

-

2652

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mus musculus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Mus musculus

-

-

2655

-

2655

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Oryctolagus cuniculus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Oryctolagus cuniculus

-

-

2657

-

2657

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Ovis aries

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Rattus norvegicus

-

-

2654

-

2654

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Rattus norvegicus

-

-

2656

-

2656

?

11-Deoxycorticosterone

20-Hydroxy-3-oxopregn-4-en-21-al

Sus scrofa

-

-

2654

-

2654

?