5.3.1.1: triose-phosphate isomerase

This is an abbreviated version!
For detailed information about triose-phosphate isomerase, go to the full flat file.

Word Map on EC 5.3.1.1

5.3.1.1

giardia

assemblage

aldolase

duodenalis

dihydroxyacetone

enolase

phosphoglycerate

zoonotic

barrel

fecal

trypanosoma

multilocus

fructose

giardiasis

dhap

cryptosporidium

brucei

protozoan

isomerases

gapdh

province

cysts

malate

stool

lamblia

methylglyoxal

phosphofructokinase

cruzi

schistosoma

enediolate

2-phosphoglycolate

parvum

hemolytic

intestinalis

fructose-1,6-bisphosphate

deamidation

alpha-enolase

1,6-bisphosphate

glucosephosphate

tim-barrel

hungarian

hominis

phosphite

dianion

phosphoglucose

glycosomes

enzymopathy

fructose-bisphosphate

ige-binding

subgenotype

diagnostics

synthesis

analysis

biofuel production

medicine

Reaction

Synonyms

CP 25, CTIMC, cTPI, cytoplasmic TPI, cytoplasmic triosephosphate isomerase, cytoTPI, D-glyceraldehyde-3-phosphate ketol-isomerase, GlTIM, Isomerase, triose phosphate, Lactacin B inducer protein, monoTIM, PfTIM, PfuTIM, Phosphotriose isomerase, plastidic TPI, plastidic triosephosphate isomerase, pTPI, SSO2592, TcTIM, TIM, TIM1, TIM2, TonTIM, TpI, TPI1, TpiA, Triose phosphate isomerase, Triose phosphate mutase, Triose phosphoisomerase, Triosephosphate isomerase, Triosephosphate mutase, vTIM

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.1 Interconverting aldoses and ketoses, and related compounds

5.3.1.1 triose-phosphate isomerase

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Results	in table
6	Activating Compound
55921	AA Sequence
14	Application
1	CAS Registry Number
66	Cloned(Commentary)
60	Crystallization (Commentary)
748	Disease/ Diagnostics
3	Expression
22	General Information
7	General Stability
35	IC50 Value
247	Inhibitors
90	kcat/KM [mM/s]
53	Ki Value [mM]
244	KM Value [mM]
56	Localization
2	Metals/Ions
69	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
7	Organic Solvent Stability
480	Organism
1	Oxidation Stability
23	Pathway
597	PDB ID
48	pH Optimum
5	pH Range
8	pH Stability
2	pI Value
2	Posttranslational Modification
155	Protein Variants
72	Purification (Commentary)
7	Reaction
2	Reaction Type
254	Reference
14	Renatured (Commentary)
49	Source Tissue
29	Specific Activity [micromol/min/mg]
4	Storage Stability
195	Substrates and Products (Substrate)
108	Subunits
199	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
3	Temperature Range [°C]
37	Temperature Stability [°C]
214	Turnover Number [1/s]

IC50 Value

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of the Enzyme Summary Page.

IC50 Value on EC 5.3.1.1 - triose-phosphate isomerase

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0.003

(1E,3E,6E,8E)-1,9-di(furan-2-yl)nona-1,3,6,8-tetraen-5-one

Trypanosoma cruzi

pH 7.4, 25°C

747584

0.1

(1Z,2Z)-N,N'-dihydroxy-4-methylcyclohexa-3,5-diene-1,2-diimine

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

(2E)-2-[(4-methyl-5-oxido-1,2,5-oxadiazol-3-yl)methylidene]hydrazinecarbothioamide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

(2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarbothioamide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

(2E)-2-[2-[(3-oxido-2,1,3-benzoxadiazol-5-yl)methoxy]benzylidene]-N-(prop-2-en-1-yl)hydrazinecarbothioamide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

(2E)-N-(naphthalen-2-yl)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxamide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.03 - 0.1

(2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxamide

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.0047

(2E,5E)-2,5-bis[(2E)-3-(thiophen-2-yl)prop-2-en-1-ylidene]cyclopentan-1-one

Trypanosoma cruzi

pH 7.4, 25°C

747584

0.000086

(2E,6E)-2,6-bis[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]cyclohexan-1-one

Trypanosoma cruzi

pH 7.4, 25°C

747584

0.0035

1,2,4-thiadiazole

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.013

1,2,6-thiadiazine

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.01

1,3,4-oxathiazole

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.03 - 0.1

2,6-dibenzyl-4-[(5-nitrothiophen-2-yl)methylidene]-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

2-phenyl-4H-chromen-4-one

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

2-[(1E)-2-nitroprop-1-en-1-yl]thiophene

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

3,5-diphenyl-1,2,4-thiadiazole

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

3-(4-methylphenyl)-5-[(4-methylphenyl)sulfonyl]-1,2,4-thiadiazole

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

3-nitrobiphenyl-4-amine

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

4-(4-nitrobenzylidene)-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.02

4-[(5-nitrofuran-2-yl)methylidene]-4H-1,2,6-thiadiazine-3,5-diamine 1,1-dioxide

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

4-[(5-nitrothiophen-2-yl)methylidene]-2,6-bis(2-phenylethyl)-1,2,6-thiadiazinane-3,5-dione 1,1-dioxide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

5-[(1E)-2-nitroprop-1-en-1-yl]-1,3-benzodioxole

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.03 - 0.1

6-[(E)-2-(5-nitrothiophen-2-yl)ethenyl]-2,1,3-benzoxadiazole 1-oxide

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.1

6-[(E)-2-[(4-fluorophenyl)sulfanyl]ethenyl]-2,1,3-benzoxadiazole 1-oxide

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.4

8-bromo-5,10-dioxidophenazin-2-yl chloroacetate

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.014

butylbrevifolin carboxylate

Trypanosoma cruzi

702595

0.1

ethyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,2,4-thiadiazole-5-carboxylate

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.03 - 0.1

ethyl 3-phenyl-1,2,4-thiadiazole-5-carboxylate

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.008

ethylbrevifolin carboxylate

Trypanosoma cruzi

702595

0.0066

methylbrevifolin carboxylate

Trypanosoma cruzi

702595

0.1

N-[(2-oxido-4-phenyl-1,2,5-oxadiazol-3-yl)methyl]naphthalen-1-amine

Trypanosoma cruzi

IC50 about 0.1 mM, in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.026

phenazine 5,9-dioxide

Trypanosoma cruzi

in 100 mM triethanolamine, 10 mM EDTA, pH 7.4 and 10% of dimethyl sulfoxide, at 36°C

714899

0.154 - 0.57

phosphoenolpyruvate

3 entries