5.3.1.1: triose-phosphate isomerase
This is an abbreviated version!
For detailed information about triose-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.1
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5.3.1.1
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giardia
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assemblage
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aldolase
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duodenalis
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dihydroxyacetone
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enolase
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phosphoglycerate
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zoonotic
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barrel
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fecal
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trypanosoma
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multilocus
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fructose
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giardiasis
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dhap
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cryptosporidium
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brucei
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protozoan
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isomerases
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gapdh
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province
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cysts
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malate
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stool
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lamblia
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methylglyoxal
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phosphofructokinase
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cruzi
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schistosoma
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enediolate
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2-phosphoglycolate
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parvum
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hemolytic
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intestinalis
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fructose-1,6-bisphosphate
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deamidation
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alpha-enolase
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1,6-bisphosphate
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glucosephosphate
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tim-barrel
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hungarian
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hominis
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phosphite
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dianion
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phosphoglucose
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glycosomes
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enzymopathy
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fructose-bisphosphate
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ige-binding
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subgenotype
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diagnostics
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synthesis
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analysis
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biofuel production
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medicine
- 5.3.1.1
- giardia
-
assemblage
- aldolase
- duodenalis
- dihydroxyacetone
- enolase
- phosphoglycerate
-
zoonotic
-
barrel
-
fecal
- trypanosoma
-
multilocus
- fructose
- giardiasis
- dhap
- cryptosporidium
- brucei
-
protozoan
- isomerases
- gapdh
-
province
- cysts
- malate
-
stool
- lamblia
- methylglyoxal
-
phosphofructokinase
- cruzi
- schistosoma
-
enediolate
- 2-phosphoglycolate
- parvum
-
hemolytic
- intestinalis
- fructose-1,6-bisphosphate
-
deamidation
- alpha-enolase
- 1,6-bisphosphate
-
glucosephosphate
-
tim-barrel
-
hungarian
- hominis
- phosphite
-
dianion
-
phosphoglucose
- glycosomes
-
enzymopathy
-
fructose-bisphosphate
-
ige-binding
-
subgenotype
- diagnostics
- synthesis
- analysis
- biofuel production
- medicine
Reaction
Synonyms
CP 25, CTIMC, cTPI, cytoplasmic TPI, cytoplasmic triosephosphate isomerase, cytoTPI, D-glyceraldehyde-3-phosphate ketol-isomerase, GlTIM, Isomerase, triose phosphate, Lactacin B inducer protein, monoTIM, PfTIM, PfuTIM, Phosphotriose isomerase, plastidic TPI, plastidic triosephosphate isomerase, pTPI, SSO2592, TcTIM, TIM, TIM1, TIM2, TonTIM, TpI, TPI1, TpiA, Triose phosphate isomerase, Triose phosphate mutase, Triose phosphoisomerase, Triosephosphate isomerase, Triosephosphate mutase, vTIM
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General Information
General Information on EC 5.3.1.1 - triose-phosphate isomerase
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malfunction
TIM deficiency is the only human glycolytic deficiency disease which is lethal, usually in early childhood. The disease symptoms concern hemolytic anemia but also neurological disorders
metabolism
physiological function
the dimeric enzyme functions in the glycolytic pathway. In the glycolysis, the catalyzed interconversion reaction is important in the thermodynamically uphill direction of the synthesis of D-glyceraldehyde 3-phosphate
metabolism
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TPIs play a very important role in gluconeogenesis, fatty acid biosynthesis, pentosephosphate pathway
metabolism
triosephosphate isomerase is a ubiquitously distributed enzyme of the glycolysis pathway
metabolism
the chloroplastic isoform participates in the Calvin-Benson cycle
metabolism
anaerobic fermentative metabolism of glycerol. Proteome analysis as well as enzyme assays performed in cell-free extracts demonstrate that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen
the plastid isoform of triose phosphate isomerase plays a crucial role in this transition from heterotrophic to autotrophic growth
physiological function
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TPI of Staphylococcus aureus is a candidate adhesion molecule for the interaction between the bacterium and the fungal pathogen Cryptococcus neoformans. TPI may recognize the mannan backbone of glucuronoxylomannan of Cryptococcus neoformans
physiological function
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the enzyme is involved in glycogen catabolism
physiological function
comparison of Saccharomyces cerevisiae and Moritella marina enzymes to evaluate the temperature dependence of the activation free energy for differently adapted triosephosphate isomerases. Moritella marina TpiA displays a shift in enthalpy-entropy balance characteristic for cold-adapted proteins, due to a few surface-exposed protein loops that show differential mobilities in the two enzymes
physiological function
comparison of Saccharomyces cerevisiae and Moritella marina enzymes to evaluate the temperature dependence of the activation free energy for differently adapted triosephosphate isomerases. Moritella marina TpiA displays a shift in enthalpy-entropy balance characteristic for cold-adapted proteins, due to a few surface-exposed protein loops that show differential mobilities in the two enzymes
physiological function
enzyme is involved in cytadherence of Mycoplasma gallisepticum
physiological function
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forced expression of TPI1 in hepatocellular carcinoma cells inhibits cell growth, migration, and invasion in vitro. Knockdown of TPI1 by shRNA promotes cell growth, migration and invasion. Overexpression of TPI1 leads to slowed tumor growth and decreased tumor weight in vivo. Cell cycle arrest is induced by TPI1 overexpression
physiological function
glycolytic regulation requires direct catalytic inhibition of TPI by the pyruvate kinase substrate phosphoenolpyruvate
physiological function
recombinant protein binds to laminin and fibronectin but not to plasminogen. Higher levels of adherence are detected in parasites grown under high-glucose conditions than in those grown under glucose-restricted conditions, and anti-TIM antibody inhibits the binding of Trichomonas vaginalis to laminin and fibronectin
physiological function
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transgenic yeast cells expressing mutations I170V or I170T accumulate greater levels of pentose phosphate pathway intermediates and have altered stress resistance, mimicking the activation of the pyruvate kinase-TPI feedback loop. Glycolytic regulation requires direct catalytic inhibition of TPI by the pyruvate kinase substrate phosphoenolpyruvate
physiological function
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comparison of Saccharomyces cerevisiae and Moritella marina enzymes to evaluate the temperature dependence of the activation free energy for differently adapted triosephosphate isomerases. Moritella marina TpiA displays a shift in enthalpy-entropy balance characteristic for cold-adapted proteins, due to a few surface-exposed protein loops that show differential mobilities in the two enzymes
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physiological function
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enzyme is involved in cytadherence of Mycoplasma gallisepticum
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physiological function
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TPI of Staphylococcus aureus is a candidate adhesion molecule for the interaction between the bacterium and the fungal pathogen Cryptococcus neoformans. TPI may recognize the mannan backbone of glucuronoxylomannan of Cryptococcus neoformans
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