5.2.1.2: maleylacetoacetate isomerase
This is an abbreviated version!
For detailed information about maleylacetoacetate isomerase, go to the full flat file.
Word Map on EC 5.2.1.2
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5.2.1.2
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dichloroacetate
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fumarylacetoacetate
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dca-induced
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succinylacetone
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chlorofluoroacetic
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homogentisate
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tyrosinemia
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medicine
- 5.2.1.2
- dichloroacetate
- fumarylacetoacetate
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dca-induced
- succinylacetone
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chlorofluoroacetic
- homogentisate
- tyrosinemia
- medicine
Reaction
Synonyms
AtGSTZ1, AtMAAI, glutathione S-transferase Zeta 1-1, glutathione S-transferase zeta-class 1, glutathione S-transferase zeta/maleylacetoacetate isomerase, glutathione transferase zeta, glutathione transferase zeta 1/maleylacetoacetate isomerase, Gstz1, GSTZ1-1, GSTz1/MAAI, GSTzeta/MAAI, Isomerase, maleylacetoacetate, MAAI, MAc-tI, maleylacetoacetate isomerase, Maleylacetoacetic isomerase, Maleylacetone cis-trans-isomerase, Maleylacetone isomerase, More
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General Information
General Information on EC 5.2.1.2 - maleylacetoacetate isomerase
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malfunction
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human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate, GSTz1/MAAI haplotype significantly affects the kinetics and biotransformation of dichloroacetate. GSTz1/MAAI variants associated with the slowest rates of dichlorocacetate metabolism induce structural changes in the enzyme homodimer, predicting protein instability or abnormal protein-protein interactions. Enzyme inhibition also results in the accumulation of the potentially hepatotoxic tyrosine intermediates maleylacetoacetate and maleylacetone and of delta-aminolevulinate
metabolism
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catalyses a significant step in the catabolism of phenylalanine and tyrosine
metabolism
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the bifunctional enzyme glutathione transferase zeta/maleylacetoacetate isomerase is the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway