5.1.99.7: dihydroneopterin triphosphate 2'-epimerase

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For detailed information about dihydroneopterin triphosphate 2'-epimerase, go to the full flat file.

Word Map on EC 5.1.99.7

5.1.99.7

epimerization

antiparallel

6-hydroxymethyl-7,8-dihydropterin

cyclohydrolase

purine

folate

tetrahydrofolate

homo-octamer

pteridine

drug development

Reaction

Synonyms

D-erythro-7,8-dihydroneopterin triphosphate epimerase, dihydroneopterin triphosphate epimerase, dihydroneopterin-triphosphate epimerase, folX, H2NTP 2'-epimerase

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.99 Acting on other compounds

5.1.99.7 dihydroneopterin triphosphate 2'-epimerase

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Results	in table
646	AA Sequence
1	Application
5	Cloned(Commentary)
1	Crystallization (Commentary)
10	General Information
1	Inhibitors
4	KM Value [mM]
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
9	Organism
4	Pathway
2	pH Optimum
4	Protein Variants
3	Purification (Commentary)
3	Reaction
6	Reference
2	Specific Activity [micromol/min/mg]
7	Substrates and Products (Substrate)
2	Subunits
8	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

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Reference on EC 5.1.99.7 - dihydroneopterin triphosphate 2'-epimerase

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5109

Hau�mann, C.; Rohdich, F.; Schmidt, E.; Bacher, A.; Richter, G.

Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase

J. Biol. Chem.

273

17418-17424

1998

Escherichia coli, Escherichia coli XL1-Blue

9651328

704330

Pribat, A.; Blaby, I.K.; Lara-Nunez, A.; Gregory, J.F.; de Crecy-Lagard, V.; Hanson, A.D.

FolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosa

J. Bacteriol.

192

475-482

2010

Escherichia coli, Pseudomonas aeruginosa (Q9HYG7), Pseudomonas aeruginosa

19897652

733859

Gabrielsen, M.; Beckham, K.S.; Cogdell, R.J.; Byron, O.; Roe, A.J.

FolX from Pseudomonas aeruginosa is octameric in both crystal and solution

FEBS Lett.

586

1160-1165

2012

Pseudomonas aeruginosa (Q9HYG7)

22575651

734122

Ahn, C.; Byun, J.; Yim, J.

Purification, cloning, and functional expression of dihydroneopterin triphosphate 2'-epimerase from Escherichia coli

J. Biol. Chem.

272

15323-15328

1997

Escherichia coli (P0AC19), Escherichia coli

9182560