5.1.99.7: dihydroneopterin triphosphate 2'-epimerase
This is an abbreviated version!
For detailed information about dihydroneopterin triphosphate 2'-epimerase, go to the full flat file.
Word Map on EC 5.1.99.7
-
5.1.99.7
-
epimerization
-
antiparallel
-
6-hydroxymethyl-7,8-dihydropterin
-
cyclohydrolase
-
purine
-
folate
-
tetrahydrofolate
-
homo-octamer
-
pteridine
-
drug development
- 5.1.99.7
-
epimerization
-
antiparallel
- 6-hydroxymethyl-7,8-dihydropterin
-
cyclohydrolase
- purine
- folate
- tetrahydrofolate
-
homo-octamer
- pteridine
- drug development
Reaction
Synonyms
D-erythro-7,8-dihydroneopterin triphosphate epimerase, dihydroneopterin triphosphate epimerase, dihydroneopterin-triphosphate epimerase, folX, H2NTP 2'-epimerase
ECTree
Advanced search results
Engineering
Engineering on EC 5.1.99.7 - dihydroneopterin triphosphate 2'-epimerase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
additional information
-
construction of an Escherichia coli strain that lacks phenylalanine hydroxylase, PhhA, and in which the expression of Pseudomonas aeruginosa PhhA plus the recycling enzyme pterin 4a-carbinolamine dehydratase PhhB, rescues tyrosine auxotrophy. This rescue is abrogated by deleting folX or folM and restored by expressing the deleted gene from a plasmid. The folX deletion selectively eliminates tetrahydromonapterin production, the mutant strain lacks tetrahydromonapterin
additional information
-
generation of a folX knockout mutant from strain SK6600
additional information
-
generation of a folX knockout mutant from strain SK6600
-
additional information
deletion of tyrA (making PhhA the sole source of tyrosine) and folX results in a strain prototrophic for tyrosine, whereas the DELTAtyrA DELTAfolX strain is auxotrophic
additional information
-
deletion of tyrA (making PhhA the sole source of tyrosine) and folX results in a strain prototrophic for tyrosine, whereas the DELTAtyrA DELTAfolX strain is auxotrophic