5.1.99.1: methylmalonyl-CoA epimerase
This is an abbreviated version!
For detailed information about methylmalonyl-CoA epimerase, go to the full flat file.
Word Map on EC 5.1.99.1
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5.1.99.1
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mutase
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methylmalonic
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propionyl-coa
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succinyl-coa
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propionate
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acidurias
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shermanii
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acidemia
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2r-methylmalonyl-coa
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b12-dependent
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adenosyl-cobalamin
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mmaa
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medicine
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hyperammonemia
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extradiol
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synthesis
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analysis
- 5.1.99.1
- mutase
-
methylmalonic
- propionyl-coa
- succinyl-coa
- propionate
- acidurias
- shermanii
- acidemia
-
2r-methylmalonyl-coa
-
b12-dependent
- adenosyl-cobalamin
- mmaa
- medicine
-
hyperammonemia
-
extradiol
- synthesis
- analysis
Reaction
Synonyms
DL-Methylmalonyl-CoA racemase, DL-Methylmalonyl-coenzyme A racemase, MCE, MCE-1, MCEE, Methylmalonyl coenzyme A racemase, methylmalonyl-CoA 2-epimerase, methylmalonyl-CoA 2-racemase, methylmalonyl-CoA epimerase, Methylmalonyl-CoA racemase, methylmalonyl-coenzyme A epimerase, mm-CoA epimerase, MMCE, Msed_0639, Racemase, methylmalonyl coenzyme A, TTE0360
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Reaction
Reaction on EC 5.1.99.1 - methylmalonyl-CoA epimerase
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(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
with (2R)-methylmalonyl-CoA as substrate: two enzyme bases act respectively as proton donor and acceptor, the release of product is slow, and the reprotonation step on the enzyme is reversible, without leading to isotopic exchange with the solvent
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(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
mechanism involving loss of the alpha-hydrogen atom with subsequent incorporation of a proton from the medium
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(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
enzyme acts to labilize the proton on the tertiary carbon atom of methylmalonyl-CoA, and thus causes a rapid exchange of this proton with those of water
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(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
two enzyme bases are involved in catalysis. One base removes the proton from the substrate, the second provides the new proton. There is no fast isotopic exchange between enzyme-bound intermediates and solvent protons
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