5.1.99.1: methylmalonyl-CoA epimerase
This is an abbreviated version!
For detailed information about methylmalonyl-CoA epimerase, go to the full flat file.
Word Map on EC 5.1.99.1
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5.1.99.1
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mutase
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methylmalonic
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propionyl-coa
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succinyl-coa
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propionate
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acidurias
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shermanii
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acidemia
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2r-methylmalonyl-coa
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b12-dependent
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adenosyl-cobalamin
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mmaa
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medicine
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hyperammonemia
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extradiol
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synthesis
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analysis
- 5.1.99.1
- mutase
-
methylmalonic
- propionyl-coa
- succinyl-coa
- propionate
- acidurias
- shermanii
- acidemia
-
2r-methylmalonyl-coa
-
b12-dependent
- adenosyl-cobalamin
- mmaa
- medicine
-
hyperammonemia
-
extradiol
- synthesis
- analysis
Reaction
Synonyms
DL-Methylmalonyl-CoA racemase, DL-Methylmalonyl-coenzyme A racemase, MCE, MCE-1, MCEE, Methylmalonyl coenzyme A racemase, methylmalonyl-CoA 2-epimerase, methylmalonyl-CoA 2-racemase, methylmalonyl-CoA epimerase, Methylmalonyl-CoA racemase, methylmalonyl-coenzyme A epimerase, mm-CoA epimerase, MMCE, Msed_0639, Racemase, methylmalonyl coenzyme A, TTE0360
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Application
Application on EC 5.1.99.1 - methylmalonyl-CoA epimerase
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analysis
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a simple direct assay for DL-methylmalonyl-coenzyme A racemase which is based on the fact that the proton on C-2 of methylmalonyl-CoA is replaced by a proton in the medium during racemization
medicine
synthesis
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as model to study human methylmalonic aciduria, deletion of the mce gene results in a 80% decreased incorporation of propionate into macromolecules and induces an accumulation of methylmalonic acid
medicine
point mutation in the methylmalonyl-CoA 2-epimerase gene (C139T) and an insertion polymorphism 41-160-161insT causes methylmalonic aciduria in patients, inhibition of the enzyme by siRNAs in HeLa cells reduces the synthesis of macromolecules
medicine
point mutation in the methylmalonyl-CoA 2-epimerase gene (C139T) results in an early termination signal and causes methylmalonic aciduria in a patient
production of polyketides like myxothiazol requiring methylmalonyl-CoA as an extender unit
synthesis
recombinant methylmalonyl-CoA epimerase enables biocatalytic epimerisation of C-2 methyl- and ethylmalonyl-CoA. When coupled with variant carboxymethylproline synthase CarB and crotonyl-CoA carboxylase reductase, the methylmalonyl-CoA epimerase forms part of a three-enzyme, one-pot procedure for the production of functionalised C-5 carboxyalkylprolines from crotonyl-CoA, carbon dioxide and L-glutamate semialdehyde/5-hydroxyproline/pyrroline-5-carboxylate