5.1.3.8: N-acylglucosamine 2-epimerase
This is an abbreviated version!
For detailed information about N-acylglucosamine 2-epimerase, go to the full flat file.
Word Map on EC 5.1.3.8
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5.1.3.8
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n-acetylneuraminic
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neu5ac
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n-acetyl-d-neuraminic
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anabaena
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mannac
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takahashi
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n-acetyl-d-mannosamine
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renbp
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nal
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n-acetylmannosamine
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synthesis
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biotechnology
- 5.1.3.8
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n-acetylneuraminic
- neu5ac
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n-acetyl-d-neuraminic
- anabaena
- mannac
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takahashi
- n-acetyl-d-mannosamine
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renbp
- nal
- n-acetylmannosamine
- synthesis
- biotechnology
Reaction
Synonyms
Acylglucosamine 2-epimerase, AGE, AGE2, anAGE, AvaAGE, bage, bGlcNAc 2-epimerase, Epimerase, acylglucosamine 2-, GlcNAc 2-epimerase, GlcNAc-2-epimerase, N-acetyl-D-glucosamine 2-epimerase, N-acetyl-D-glucosamine-2-epimerase, N-Acetylglucosamine 2-epimerase, N-acyl-D-glucosamine 2-epimerase, N-acylglucosamine 2-epimerase, PhGn2E, renin binding protein, Renin-binding protein, RNBP
ECTree
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Application
Application on EC 5.1.3.8 - N-acylglucosamine 2-epimerase
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biotechnology
synthesis
additional information
the mammalian enzyme is a target for development inhibitors for sialic acid biosynthesis
coupled bioconversion for preparation of N-acetyl-D-neuraminic acid using immobilized N-acetyl-D-glucosamine-2-epimerase and N-acetyl-D-neuraminic acid lyase, a two-step enzymatic system involving immobilized both enzymes is used for the conversion of GlcNAc to NeuAc in a single reactor, optimum ratio is 3-6.25 U/ml of N-acetyl-D-glucosamine-2-epimerase and 12.5-25 U/ml of N-acetyl-D-neuraminic acid lyase
biotechnology
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efficient method for N-acetyl-D-neuraminic acid production using coupled bacterial cells with a safe temperature-induced system, a precursor for producing many pharmaceutical drugs such as zanamivir which have been used in clinical trials to treat and prevent the infection with influenza virus, such as the avian influenza virus H5N1 and the current 2009 H1N1
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production of N-acetyl-D-neuraminic acid by coupling bacteria expressing N-acetyl-D-glucosamine 2-epimerase and N-acetyl-D-neuraminic acid synthetase. Microbial production of N-acetylneuraminic acid is carried out using Escherichia coli overexpressing N-acylglucosamine 2-epimerase and NeuAc synthetase as enzyme sources. Phosphoenolpyruvate and ATP, required as a substrate or a cofactor of the enzymes, are supplied by the activities of Escherichia coli and Corynebacterium ammoniagenes cells. Starting with 800 mM GlcNAc and 360 mM glucose, NeuAc accumulates at 39.7 mM after 22 h
synthesis
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production of N-acetylneuraminic acid from N-acetylglucosamine and pyruvate using recombinant human renin binding protein showing GlcNAc-2-epimerase activity and sialic acid aldolase in a coupling reaction
synthesis
BoAGE2 a promising biocatalyst for sialic acid production using cheap GlcNAc as starting material
synthesis
recombinant Escherichia coli cells synchronously expressing N-acetyl-D-glucosamine-2-epimerase and N-acetyl-D-neuraminic acid aldolase as biocatalysts can potentially be used in the industrial mass production of Neu5Ac
synthesis
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BoAGE2 a promising biocatalyst for sialic acid production using cheap GlcNAc as starting material
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