5.1.3.18: GDP-mannose 3,5-epimerase

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For detailed information about GDP-mannose 3,5-epimerase, go to the full flat file.

Reaction

Synonyms

Epimerase, guanosine diphosphomannose, GDP-D-mannose 3'',5''-epimerase, GDP-D-mannose 3',5'-epimerase, GDP-D-mannose 3,5-epimerase, GDP-D-mannose-3',5'-epimerase, GDP-D-mannose:GDP-L-galactose epimerase, GDP-mannose 3",5"-epimerase, GDP-mannose 3',5'-epimerase, GDP-mannose-3',5'-epimerase, GME, GME1, GME2, OsGME

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.18 GDP-mannose 3,5-epimerase

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1	Activating Compound
64	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
4	Expression
10	General Information
1	IC50 Value
10	Inhibitors
9	KM Value [mM]
2	Localization
6	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
19	Organism
11	Pathway
8	PDB ID
4	pH Optimum
2	pH Range
2	pI Value
1	Protein Variants
3	Purification (Commentary)
5	Reaction
1	Reaction Type
19	Reference
19	Source Tissue
2	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

Systematic Name

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SYSTEMATIC NAME

IUBMB Comments

GDP-alpha-D-mannose 3,5-epimerase

The enzyme catalyses the formation of the stable intermediate GDP-beta-L-gulose as well as GDP-beta-L-galactose. The reaction proceeds by C4' oxidation of GDP-alpha-D-mannose followed by epimerization of the C5' position to give GDP-beta-L-4-dehydro-gulose. This intermediate is either reduced to give GDP-beta-L-gulose or the C3' position is epimerized to give GDP-beta-L-4-dehydro-galactose, followed by C4' reduction to yield GDP-beta-L-galactose. Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways.