5.1.3.18: GDP-mannose 3,5-epimerase
This is an abbreviated version!
For detailed information about GDP-mannose 3,5-epimerase, go to the full flat file.
Word Map on EC 5.1.3.18
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5.1.3.18
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ascorbate
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asa
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l-ascorbic
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tomato
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phosphorylase
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pyrophosphorylase
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l-galactose-1-phosphate
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l-galactono-1,4-lactone
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lycopersicum
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dehydroascorbate
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gpp
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epimerization
- 5.1.3.18
- ascorbate
- asa
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l-ascorbic
- tomato
- phosphorylase
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pyrophosphorylase
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l-galactose-1-phosphate
- l-galactono-1,4-lactone
- lycopersicum
- dehydroascorbate
- gpp
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epimerization
Reaction
Synonyms
Epimerase, guanosine diphosphomannose, GDP-D-mannose 3'',5''-epimerase, GDP-D-mannose 3',5'-epimerase, GDP-D-mannose 3,5-epimerase, GDP-D-mannose-3',5'-epimerase, GDP-D-mannose:GDP-L-galactose epimerase, GDP-mannose 3",5"-epimerase, GDP-mannose 3',5'-epimerase, GDP-mannose-3',5'-epimerase, GME, GME1, GME2, OsGME
ECTree
5.1.3.18 GDP-mannose 3,5-epimeraseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.1.3.18 - GDP-mannose 3,5-epimerase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-alpha-D-mannose
GDP-beta-L-galactose
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GDP-D-mannose undergoes double epimerization catalyzed by GDP-D-mannose-3',5'-epimerase to form GDP-L-galactose
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?
GDP-D-mannose
GDP-L-galactose
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the reaction mixture contains at equilibrium GDP-D-mannose, GDP-L-galactose and GDP-L-gulose in a ratio of 1:0.4:0.2
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r
GDP-D-mannose
GDP-L-galactose
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the enzyme catalyzes a reversible epimerization that precedes the committed step in the biosynthesis of vitamin C, resulting in the hydrolysis of the highly energetic glycosyl-diphosphoryl linkage. The plant enzyme undergoes a complex regulation and could control the carbonflux into the vitamin C pathway in response to the redox state of thecell, stress conditions, and GDP-sugar demand for the cell wall glycoprotein biosynthesis
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r
GDP-D-mannose
GDP-L-galactose
key enzyme in biosynthesis of vitamin C in plants
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?
additional information
?
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key enzyme of the plant vitamin C pathway
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?
additional information
?
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key enzyme of the plant vitamin C pathway
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?
additional information
?
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methyl jasmonate stimulates the de novo biosynthesis of vitamin C in plant cell suspensions. This stimulation coincides with enhanced transcription of GDP-mannose 3'',5''-epimerase
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?
