5.1.3.18: GDP-mannose 3,5-epimerase
This is an abbreviated version!
For detailed information about GDP-mannose 3,5-epimerase, go to the full flat file.
Word Map on EC 5.1.3.18
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5.1.3.18
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ascorbate
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asa
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l-ascorbic
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tomato
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phosphorylase
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pyrophosphorylase
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l-galactose-1-phosphate
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l-galactono-1,4-lactone
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lycopersicum
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dehydroascorbate
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gpp
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epimerization
- 5.1.3.18
- ascorbate
- asa
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l-ascorbic
- tomato
- phosphorylase
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pyrophosphorylase
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l-galactose-1-phosphate
- l-galactono-1,4-lactone
- lycopersicum
- dehydroascorbate
- gpp
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epimerization
Reaction
Synonyms
Epimerase, guanosine diphosphomannose, GDP-D-mannose 3'',5''-epimerase, GDP-D-mannose 3',5'-epimerase, GDP-D-mannose 3,5-epimerase, GDP-D-mannose-3',5'-epimerase, GDP-D-mannose:GDP-L-galactose epimerase, GDP-mannose 3",5"-epimerase, GDP-mannose 3',5'-epimerase, GDP-mannose-3',5'-epimerase, GME, GME1, GME2, OsGME
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General Information
General Information on EC 5.1.3.18 - GDP-mannose 3,5-epimerase
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malfunction
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silencing of the two GME genes in tomato leaves results in approximately a 60% decrease in terminal L-galactose content in the side chain A of rhamnogalacturonan II as well as in a lower capacity of rhamnogalacturonan II to perform in muro cross-linking
metabolism
physiological function
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GME is a central enzyme of the major ascorbate biosynthesis pathway in higher plants, it play a key role in the regulation of ascorbate biosynthesis in plants, adjusting the balance between ascorbate and cell-wall monosaccharide biosynthesis. GDP-D-mannose synthesis is the initial step in the pathway of ascorbate biosynthesis, and GDP-D-mannose is also a known precursor for the synthesis of D-mannose, L-fucose and L-galactose, and therefore for hemicelluloses such s the (galacto)glucomannans and for the pectin rhamnogalacturonan II
metabolism
GDP-D-mannose 3',5'-epimerase catalyses a committed step in ascorbic acid biosynthesis
metabolism
GDP-D-mannose 3',5'-epimerase catalyses a committed step in ascorbic acid biosynthesis
transgenic plants over-expressing isoform GME1 exhibit a significant increase in total ascorbic acid in leaves and red fruits compared with wild type plants and improved tolerance to methyl viologen, cold, and salt stresses
physiological function
transgenic plants over-expressing isoform GME2 exhibit a significant increase in total ascorbic acid in leaves and red fruits compared with wild type plants and improved tolerance to methyl viologen, cold, and salt stresses
physiological function
GDP-D-mannose 3',5'-epimerase catalyses a committed step in ascorbic acid biosynthesis, ascorbic acid plays important roles in antioxidative defenses against environmental stresses in higher plants
physiological function
GDP-D-mannose 3',5'-epimerase catalyses a committed step in ascorbic acid biosynthesis, ascorbic acid plays important roles in antioxidative defenses against environmental stresses in higher plants