5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase
This is an abbreviated version!
For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.
Word Map on EC 5.1.3.17
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5.1.3.17
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l-iduronic
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d-glucuronic
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epimerization
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proteoglycans
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idoa
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glycosaminoglycans
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glca
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n-sulfated
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2-o-sulfotransferase
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hexuronic
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hspgs
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2-o-sulfation
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mastocytoma
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mannuronan
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lindahl
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o-desulfated
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medicine
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diagnostics
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analysis
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synthesis
- 5.1.3.17
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l-iduronic
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d-glucuronic
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epimerization
- proteoglycans
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idoa
- glycosaminoglycans
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glca
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n-sulfated
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2-o-sulfotransferase
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hexuronic
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hspgs
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2-o-sulfation
- mastocytoma
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mannuronan
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lindahl
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o-desulfated
- medicine
- diagnostics
- analysis
- synthesis
Reaction
Synonyms
C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase
ECTree
5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimeraseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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-
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?
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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-
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?
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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-
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?
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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C5-epimerization is irreversible in vivo
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ir
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview
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?
Heparosan-N-sulfate D-glucuronate
Heparosan-N-sulfate L-iduronate
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the enzyme controle heparan sulfate chain flexibility, its activity, modifiying the substrate, is required for proper lymphoid organ development, overview
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?
additional information
?
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enzyme catalyzes formation of L-iduronic acid residues in the course of heparin biosynthesis
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?
additional information
?
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enzyme is involved in the biosynthesis of heparan sulfate in liver
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?
additional information
?
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key heparan sulfate modifying enzyme, a biosynthetic step that enhances biological activity of heparan sulfate. The enzyme is an important determinant of dorso-ventral axis formation and patterning in zebrafish
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?
additional information
?
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limiting factor in dermatan sulfate biosynthesis
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?
additional information
?
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the D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
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?
additional information
?
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the D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
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?
additional information
?
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the enzyme is known for being a two-way catalytic enzyme, displaying a reversible catalytic mode by converting a glucuronic acid to an iduronic acid residue, and vice versa. The enzyme can also serve as a one-way catalyst to convert a glucuronic acid to an iduronic acid residue, displaying an irreversible catalytic mode. The reversible or irreversible catalytic mode strictly depends on the saccharide substrate structures
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?
additional information
?
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enzyme catalyzes formation of L-iduronic acid residues in the course of heparin biosynthesis
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?
additional information
?
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L-iduronosyl moieties are formed after N-sulfation but before O-sulfation
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?
additional information
?
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the enzyme is involved in the biosynthesis of heparin and heparan sulfate
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?
additional information
?
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the enzyme is involved in the biosynthesis of heparin and heparan sulfate
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?
