5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase

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For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.

Reaction

Synonyms

C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase

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Results	in table
1524	AA Sequence
6	Application
1	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
2	Expression
21	General Information
7	Inhibitors
4	KM Value [mM]
2	Localization
2	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
244	Organism
3	Pathway
9	PDB ID
5	pH Optimum
2	pH Range
1	Posttranslational Modification
28	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
84	Reference
46	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
9	Subunits
99	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

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Cloned on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Danio rerio

-

661398

cloned into a baculovirus expression vector and expressed in Sf9 insect cells

Bos taurus

O18756

2294

DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic tree, recombinant expression of soluble FLAG-tagged enzyme mutant lacking the transmembrane domain (N-terminal 33 amino acids) in insect cells using the baculovirus expression system

Lissachatina fulica

O94923

747914

enzyme GLCE is ectopically re-expressed in morphologically different LNCaP and PC3 prostate cancer cells, quantitative real-time PCR enzyme expression analysis

Homo sapiens

O94923

749412

expressed in U2020 cells

Homo sapiens

O94923

714635

expression of wild-type and mutant enzymes in Escherichia coli strain DE3

Homo sapiens

-

704649

gene glce, recombinant expression of enzyme mutant comprising residues Arg50-Asn585 as N-terminally His6-SUMO-tagged enzyme in Escherichia coli strain BL21(DE3), expression of N-terminally His6-SUMO-tagged SeMet-substituted Glce protein in Escherichia coli strain B834, expression of diverse enzyme point mutants

Danio rerio

F1QR43

748202

gene Hsepi

Mus musculus

-

704486

gene RED65_08024, design and synthesis of a synthetic based on hypothetical protein RED65_08024, codon optimized for the codon usage bias of Escherichia coli, expression of the recombinant His-tagged enzyme in Escherichia coli strain Rossetta(DE3)/pWUR537

Bermanella marisrubri

Q1N097

727955

recombinant expression in Escherichia coli

Homo sapiens

-

727904

recombinant full-length enzyme, expressed in insect Sf9 cells

Mus musculus

Q9EPS3

652129

recombinant MBP-tagged enzyme in Escherichia coli strain Rosetta-gami B (DE3), coexpression with 2-O-sulfotransferase

Homo sapiens

O94923

746780