5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase
This is an abbreviated version!
For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.
Word Map on EC 5.1.3.17
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5.1.3.17
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l-iduronic
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d-glucuronic
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epimerization
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proteoglycans
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idoa
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glycosaminoglycans
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glca
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n-sulfated
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2-o-sulfotransferase
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hexuronic
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hspgs
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2-o-sulfation
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mastocytoma
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mannuronan
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lindahl
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o-desulfated
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medicine
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diagnostics
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analysis
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synthesis
- 5.1.3.17
-
l-iduronic
-
d-glucuronic
-
epimerization
- proteoglycans
-
idoa
- glycosaminoglycans
-
glca
-
n-sulfated
-
2-o-sulfotransferase
-
hexuronic
-
hspgs
-
2-o-sulfation
- mastocytoma
-
mannuronan
-
lindahl
-
o-desulfated
- medicine
- diagnostics
- analysis
- synthesis
Reaction
Synonyms
C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase
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Application
Application on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase
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analysis
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assay procedure for heparosan-N-sulfate-glucuronate 5-epimerase, which is based on the use of a two-phase system for liquid scintillation counting
diagnostics
GLCE upregulation plus expression pattern of a panel of six genes, discriminating morphologically different prostate cancer cell subtypes, is a potential marker of aggressive prostate cancer
medicine
synthesis
the enzyme, coexpressed with 2-O-sulfotransferase in bacteria, can be used for production of bioengineered heparin as a potential substitute for the animal-sourced anticoagulant drug
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in 82-84% of human breast tumors there is either downregulation or loss of D-glucuronyl C5-epimerase mRNA expression and significant decrease of the protein content. In 77% of cases, GLCE expression is decreased also in the normal-appearing tissue surrounding the tumor node but the protein amount is comparable to normal breast tissue
medicine
the anti-tumour effects associated with ectopic GLCE re-expression suggest that it may be a potential tumour-suppressor gene and a possible target for lung cancer diagnosis and treatment
medicine
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the enzyme is a candidate molecular marker for advanced prostate cancer