5.1.3.14: UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) This is an abbreviated version! For detailed information about UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing), go to the full flat file .
Reaction
UDP-N-acetyl-alpha-D-glucosamine =
UDP-N-acetyl-alpha-D-mannosamine
Synonyms bas5048, bas5117, Bs-epimerase, Cap5P, Epimerase, uridine diphosphoacetylglucosamine 2-, GNE, GNE/MNK, GNE1, GNE2, GneY, GneZ, His-rGNE, Mj-epimerase, MnaA, More, NeuC protein, NmSacA, non-hydrolyzing Neisseria meningitidis serogroup A UDP-GlcNAc 2-epimerase, non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine 2-epimerase, non-hydrolyzing UDP-GlcNAc 2-epimerase, non-hydrolyzing UDP-N-acetylglucosamine 2-epimerase, non-hydrolyzing uridine 5'-diphosphate-N-acetylglucosamine 2-epimerase, SacA, teichoic acid 2-epimerase, UDP-GlcNAc 2'-epimerase, UDP-GlcNAc 2-epimerase, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase gene, UDP-GlcNAc-2-epimerase, UDP-GlcNAc:UDP-ManNAc 2-epimerase, UDP-N-acetylglucosamine 2'-epimerase, UDP-N-acetylglucosamine 2-epimerase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase, uridine diphosphate N-acetylglucosamine 2-epimerase, Uridine diphosphate-N-acetylglucosamine-2'-epimerase, Uridine diphospho-N-acetylglucosamine 2'-epimerase, Uridine diphosphoacetylglucosamine 2'-epimerase, wecB, WTA 2-epimerase
ECTree
Source Tissue
Source Tissue on EC 5.1.3.14 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
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HIV-infected. Downregulation of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase in hyposialylated HIV-infected T cells
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cell proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration. Growth-related genes are differentially expressed in GNE-deficient embryonic stem cells compared to wild-type embryonic stem cells
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skin
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enzyme activity is 18% of the activity found in normal livers
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human epithel, HEK AD293
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additional information
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GNE2 and GNE3 display tissue-specific expression patterns
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enzyme activity is significantly elevated at 8 h after intradermal injection of carageenan or urate crystals, falling to normal levels by day 3
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enzyme activity is significantly elevated at 8 h after intradermal injection of carageenan or urate crystals, falling to normal levels by day 3
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enzyme is detected only in sialoglycoprotein-secreting tissues
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colonic mucosa: normal mucosa, non-malignant mucosa in azomethane treated animals, low activity in azomethane-induced tumor tissue
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activity in colonic tissue is 25-50times lower than in liver
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activity in colonic tissue is 25-50times lower than in liver
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colonic mucosa: normal mucosa, non-malignant mucosa in azomethane treated animals, low activity in azomethane-induced tumor tissue
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enzyme is detected only in sialoglycoprotein-secreting tissues
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enzyme activity is low at birth, increases to a maximum value on day 15, and falls gradually until day 30, thereafter it increases up to the 60th day
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high expression level
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high expression level
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enzyme activity increases in livers of tumor-bearing animals
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enzyme is detected only in sialoglycoprotein-secreting tissues
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enzyme activity is significantly elevated at 8 h after intradermal injection of carrageenan or urate crystals, falling to normal levels by day 3
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enzyme activity is low at birth, increases to a maximum value on day 15, and falls gradually until day 30, thereafter it increases up to the 60th day
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high expression level
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enzyme activity is significantly elevated at 8 h after intradermal injection of carrageenan or urate crystals, falling to normal levels by day 3
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enzyme is detected only in sialoglycoprotein-secreting tissues
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high expression level
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high expression level
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high expression level
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enzyme is detected only in sialoglycoprotein-secreting tissues
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enzyme is detected only in sialoglycoprotein-secreting tissues
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enzyme is detected only in sialoglycoprotein-secreting tissues
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developmentally regulated: high levels in immature myoblast but low levels in mature skeletal muscle
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