5.1.3.14: UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)

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For detailed information about UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing), go to the full flat file.

Word Map on EC 5.1.3.14

5.1.3.14

sialic

myopathy

hereditary

rimmed

sialylation

vacuoles

n-acetylneuraminic

quadriceps

sialuria

glycoconjugates

hyposialylation

udp-n-acetylmannosamine

nonaka

neu5ac

inclusion-body

drug development

cmp-neu5ac

cmp-n-acetylneuraminic

cmp-sialic

medicine

synthesis

biotechnology

Reaction

Synonyms

bas5048, bas5117, Bs-epimerase, Cap5P, Epimerase, uridine diphosphoacetylglucosamine 2-, GNE, GNE/MNK, GNE1, GNE2, GneY, GneZ, His-rGNE, Mj-epimerase, MnaA, More, NeuC protein, NmSacA, non-hydrolyzing Neisseria meningitidis serogroup A UDP-GlcNAc 2-epimerase, non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine 2-epimerase, non-hydrolyzing UDP-GlcNAc 2-epimerase, non-hydrolyzing UDP-N-acetylglucosamine 2-epimerase, non-hydrolyzing uridine 5'-diphosphate-N-acetylglucosamine 2-epimerase, SacA, teichoic acid 2-epimerase, UDP-GlcNAc 2'-epimerase, UDP-GlcNAc 2-epimerase, UDP-GlcNAc 2-epimerase/ManAc kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase, UDP-GlcNAc 2-epimerase/ManNAc kinase gene, UDP-GlcNAc-2-epimerase, UDP-GlcNAc:UDP-ManNAc 2-epimerase, UDP-N-acetylglucosamine 2'-epimerase, UDP-N-acetylglucosamine 2-epimerase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-N-acetylglucosamine-2-epimerase, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase, uridine diphosphate N-acetylglucosamine 2-epimerase, Uridine diphosphate-N-acetylglucosamine-2'-epimerase, Uridine diphospho-N-acetylglucosamine 2'-epimerase, Uridine diphosphoacetylglucosamine 2'-epimerase, wecB, WTA 2-epimerase

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.3 Acting on carbohydrates and derivatives

5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)

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Results	in table
11	Activating Compound
14738	AA Sequence
9	Application
1	CAS Registry Number
29	Cloned(Commentary)
7	Crystallization (Commentary)
219	Disease/ Diagnostics
46	General Information
3	General Stability
123	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
26	KM Value [mM]
28	Localization
4	Metals/Ions
16	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
101	Organism
13	Pathway
41	PDB ID
13	pH Optimum
4	pH Range
3	Posttranslational Modification
121	Protein Variants
21	Purification (Commentary)
13	Reaction
1	Reaction Type
91	Reference
59	Source Tissue
8	Specific Activity [micromol/min/mg]
10	Storage Stability
123	Substrates and Products (Substrate)
27	Subunits
128	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
12	Turnover Number [1/s]

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Application on EC 5.1.3.14 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)

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biotechnology

Rattus norvegicus

production of erythropoietin (EPO) in Chinese Hamster Ovary (CHO) cells

673699

drug development

6 entries

medicine

Homo sapiens

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase interacts with the non-muscle form of alpha-actinin, alpha-actinin-1, in mature skeletal muscle cells. No significant difference in the binding of alpha-actinin-1 with either wild-type or mutant enzyme, and therefore no conclusions wether and how the interaction is relevant to the muscle-restricted pathology of hereditary inclusion body myopathy

694815

synthesis

Mus musculus

transgenic Arabidopsis thaliana plants expressing three key enzymes of the mammalian Neu5Ac biosynthesis pathway: UDPN-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, N-acetylneuraminic acid phosphate synthase, and CMP-Nacetylneuraminic acid synthetase. Simultaneous expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase and N-acetylneuraminic acid phosphate synthase results in the generation of significant Neu5Ac amounts of 1275 nmol per g fresh weight in leaves, which can be further converted to cytidine monophospho-N-acetylneuraminic acid by coexpression of CMP-N-acetylneuraminic acid synthetase

689622