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5.1.3.11: cellobiose epimerase

This is an abbreviated version!
For detailed information about cellobiose epimerase, go to the full flat file.

Word Map on EC 5.1.3.11

Reaction

cellobiose
=
4-O-beta-D-glucopyranosyl-D-mannose

Synonyms

B15CE, BfCE, BN699_02313, Caob-CE, CE-NE1, ce13, cellobiose 2-epimerase, CS-HRCE, Csac_0294, CsCE, CvCE, DfCE, Dfer_1975, DsCE, DtCE, Dtur_0652, EcCE, EpiA, epilactose-producing cellobiose 2-epimerase, Epimerase, cellobiose, FbCE, FjCE, Fjoh_4956, HaCE, Haur_0887, mannobiose 2-epimerase, md1, md2, PhCE, Phep_3983, RACE, Rmar_2439, RmCE, SdCE, Sde_0508, SlCE, Slin_0271, Spith_0082, StCE, STHERM_c00950, TERTU_4095, Thsa-CE, TtCE

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.11 cellobiose epimerase

Reference

Reference on EC 5.1.3.11 - cellobiose epimerase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Amein, M.; Leatherwood, J.M.
Mechanism of cellobiose epimerase
Biochem. Biophys. Res. Commun.
36
223-227
1969
Ruminococcus albus
Manually annotated by BRENDA team
Tyler, T.R.; Leatherwood, J.M.
Epimerization of disaccharides by enzyme preparations from Ruminococcus albus
Arch. Biochem. Biophys.
119
363-367
1967
Ruminococcus albus
Manually annotated by BRENDA team
Ito, S.; Hamada, S.; Yamaguchi, K.; Umene, S.; Ito, H.; Matsui, H.; Ozawa, T.; Taguchi, H.; Watanabe, J.; Wasaki, J.; Ito, S.
Cloning and sequencing of the cellobiose 2-epimerase gene from an obligatory anaerobe, Ruminococcus albus
Biochem. Biophys. Res. Commun.
360
640-645
2007
Ruminococcus albus (P0DKY4), Ruminococcus albus
Manually annotated by BRENDA team
Ito, S.; Taguchi, H.; Hamada, S.; Kawauchi, S.; Ito, H.; Senoura, T.; Watanabe, J.; Nishimukai, M.; Ito, S.; Matsui, H.
Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme
Appl. Microbiol. Biotechnol.
79
433-441
2008
Ruminococcus albus
Manually annotated by BRENDA team
Taguchi, H.; Senoura, T.; Hamada, S.; Matsui, H.; Kobayashi, Y.; Watanabe, J.; Wasaki, J.; Ito, S.
Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens
FEMS Microbiol. Lett.
287
34-40
2008
[Eubacterium] cellulosolvens (B3XZI5), [Eubacterium] cellulosolvens
Manually annotated by BRENDA team
Senoura, T.; Taguchi, H.; Ito, S.; Hamada, S.; Matsui, H.; Fukiya, S.; Yokota, A.; Watanabe, J.; Wasaki, J.; Ito, S.
Identification of the cellobiose 2-epimerase gene in the genome of Bacteroides fragilis NCTC 9343
Biosci. Biotechnol. Biochem.
73
400-406
2009
Ruminococcus albus (P0DKY4), Bacteroides fragilis (Q5LH66), Bacteroides fragilis
Manually annotated by BRENDA team
Ito, S.; Hamada, S.; Ito, H.; Matsui, H.; Ozawa, T.; Taguchi, H.; Ito, S.
Site-directed mutagenesis of possible catalytic residues of cellobiose 2-epimerase from Ruminococcus albus
Biotechnol. Lett.
31
1065-1071
2009
Ruminococcus albus (P0DKY4), Ruminococcus albus
Manually annotated by BRENDA team
Park, C.S.; Kim, J.E.; Choi, J.G.; Oh, D.K.
Characterization of a recombinant cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus and its application in the production of mannose from glucose
Appl. Microbiol. Biotechnol.
92
1187-1196
2011
Caldicellulosiruptor saccharolyticus
Manually annotated by BRENDA team
Saburi, W.; Yamamoto, T.; Taguchi, H.; Hamada, S.; Matsui, H.
Practical preparation of epilactose produced with cellobiose 2-epimerase from Ruminococcus albus NE1
Biosci. Biotechnol. Biochem.
74
1736-1737
2010
Ruminococcus albus, Ruminococcus albus NE1
Manually annotated by BRENDA team
Kim, Y.S.; Oh, D.K.
Lactulose production from lactose as a single substrate by a thermostable cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus
Biores. Technol.
104
668-672
2012
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus
Manually annotated by BRENDA team
Kim, Y.S.; Kim, J.E.; Oh, D.K.
Borate enhances the production of lactulose from lactose by cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus
Biores. Technol.
128
809-812
2013
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus
Manually annotated by BRENDA team
Ojima, T.; Saburi, W.; Sato, H.; Yamamoto, T.; Mori, H.; Matsui, H.
Biochemical characterization of a thermophilic cellobiose 2-epimerase from a thermohalophilic bacterium, Rhodothermus marinus JCM9785
Biosci. Biotechnol. Biochem.
75
2162-2168
2011
Rhodothermus marinus (F8WRK9), Rhodothermus marinus, Rhodothermus marinus JCM 9785 (F8WRK9), Rhodothermus marinus JCM 9785
Manually annotated by BRENDA team
Sato, H.; Saburi, W.; Ojima, T.; Taguchi, H.; Mori, H.; Matsui, H.
Immobilization of a thermostable cellobiose 2-epimerase from Rhodothermus marinus JCM9785 and continuous production of epilactose
Biosci. Biotechnol. Biochem.
76
1584-1587
2012
Rhodothermus marinus (F8WRK9), Rhodothermus marinus, Rhodothermus marinus JCM 9785 (F8WRK9), Rhodothermus marinus JCM 9785
Manually annotated by BRENDA team
Kim, J.E.; Kim, Y.S.; Kang, L.W.; Oh, D.K.
Characterization of a recombinant cellobiose 2-epimerase from Dictyoglomus turgidum that epimerizes and isomerizes beta-1,4- and alpha-1,4-gluco-oligosaccharides
Biotechnol. Lett.
34
2061-2068
2012
Dictyoglomus turgidum, Dictyoglomus turgidum DSM 6724
Manually annotated by BRENDA team
Fujiwara, T.; Saburi, W.; Inoue, S.; Mori, H.; Matsui, H.; Tanaka, I.; Yao, M.
Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar
FEBS Lett.
587
840-846
2013
Ruminococcus albus
Manually annotated by BRENDA team
Fujiwara, T.; Saburi, W.; Matsui, H.; Mori, H.; Yao, M.
Structural insights into the epimerization of beta-1,4-linked oligosaccharides catalyzed by cellobiose 2-epimerase, the sole enzyme epimerizing non-anomeric hydroxyl groups of unmodified sugars
J. Biol. Chem.
289
3405-3415
2014
Rhodothermus marinus (F8WRK9), Rhodothermus marinus
Manually annotated by BRENDA team
Wasaki, J.; Taguchi, H.; Senoura, T.; Akasaka, H.; Watanabe, J.; Kawaguchi, K.; Komata, Y.; Hanashiro, K.; Ito, S.
Identification and distribution of cellobiose 2-epimerase genes by a PCR-based metagenomic approach
Appl. Microbiol. Biotechnol.
99
4287-4295
2015
uncultured bacterium (A0A0A1H8D7), uncultured bacterium (A0A0A1HAT7)
Manually annotated by BRENDA team
Wu, L.; Xu, C.; Li, S.; Liang, J.; Xu, H.; Xu, Z.
Efficient production of lactulose from whey powder by cellobiose 2-epimerase in an enzymatic membrane reactor
Biores. Technol.
233
305-312
2017
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus, Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331 (A4XGA6)
Manually annotated by BRENDA team
Saburi, W.; Tanaka, Y.; Muto, H.; Inoue, S.; Odaka, R.; Nishimoto, M.; Kitaoka, M.; Mori, H.
Functional reassignment of Cellvibrio vulgaris EpiA to cellobiose 2-epimerase and an evaluation of the biochemical functions of the 4-O-beta-D-mannosyl-D-glucose phosphorylase-like protein, UnkA
Biosci. Biotechnol. Biochem.
79
969-977
2015
Cellvibrio vulgaris, Cellvibrio vulgaris NCIMB8633
Manually annotated by BRENDA team
Saburi, W.
Functions, structures, and applications of cellobiose 2-epimerase and glycoside hydrolase family 130 mannoside phosphorylases
Biosci. Biotechnol. Biochem.
80
1294-1305
2016
Cellvibrio vulgaris, Caldicellulosiruptor saccharolyticus (A4XGA6), Flavobacterium johnsoniae (A5FA14), Herpetosiphon aurantiacus (A9AYF3), [Eubacterium] cellulosolvens (B3XZI5), Dictyoglomus turgidum (B8DZK4), Teredinibacter turnerae (C5BUF0), Teredinibacter turnerae (K7ZLA5), Dyadobacter fermentans (C6VW66), Pedobacter heparinus (C6XVU9), Spirosoma linguale (D2QDA5), Spirochaeta thermophila (E0RU15), Spirochaeta thermophila (G0GBL0), Rhodothermus marinus (F8WRK9), Ruminococcus albus (P0DKY4), Saccharophagus degradans (Q21NF7), Bacteroides fragilis (Q5LH66), Bacteroides fragilis ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343 (Q5LH66), Spirochaeta thermophila ATCC 49972 / DSM 6192 / RI 19.B1 (E0RU15), Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331 (A4XGA6), Herpetosiphon aurantiacus ATCC 23779 / DSM 785 (A9AYF3), Spirosoma linguale ATCC 33905 / DSM 74 / LMG 10896 (D2QDA5), Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 (C6XVU9), Saccharophagus degradans 2-40 / ATCC 43961 / DSM 17024 (Q21NF7), Teredinibacter turnerae ATCC 39867 / T7901 (C5BUF0), Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114 (C6VW66), Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101 (A5FA14), Dictyoglomus turgidum Z-1310 / DSM 6724 (B8DZK4), Spirochaeta thermophila ATCC 700085 / DSM 6578 / Z-1203 (G0GBL0)
Manually annotated by BRENDA team
Park, C.; Kim, J.; Lee, S.; Kim, Y.; Kang, L.; Oh, D.
Characterization of a recombinant mannobiose 2-epimerase from Spirochaeta thermophila that is suggested to be a cellobiose 2-epimerase
Biotechnol. Lett.
35
1873-1880
2013
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus, Spirochaeta thermophila (E0RU15), Spirochaeta thermophila, Spirochaeta thermophila DSM 6724 (E0RU15)
Manually annotated by BRENDA team
Shen, Q.; Zhang, Y.; Yang, R.; Pan, S.; Dong, J.; Fan, Y.; Han, L.
Enhancement of isomerization activity and lactulose production of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus
Food Chem.
207
60-67
2016
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus
Manually annotated by BRENDA team
Wang, M.; Yang, R.; Hua, X.; Shen, Q.; Zhang, W.; Zhao, W.
Lactulose production from lactose by recombinant cellobiose 2-epimerase in permeabilised Escherichia coli cells
Int. J. Food Sci. Technol.
50
1625-1631
2015
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331 (A4XGA6)
-
Manually annotated by BRENDA team
Kuschel, B.; Seitl, I.; Glueck, C.; Mu, W.; Jiang, B.; Stressler, T.; Fischer, L.
Hidden reaction mesophilic cellobiose 2-epimerases produce lactulose
J. Agric. Food Chem.
65
2530-2539
2017
Butyrivibrio sp. AE2015, Dyadobacter fermentans (C6VW66), Rhodothermus marinus (D0MF61), Rhodothermus marinus (F8WRK9), Ruminococcus albus (P0DKY4), Bacteroides fragilis (Q5LH66), Firmicutes bacterium (R7AVK7), Rhodothermus marinus ATCC 43812 / DSM 4252 / R-10 (D0MF61), Bacteroides fragilis DSM 2151 (Q5LH66), Ruminococcus albus DSM 20455 (P0DKY4), Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114 (C6VW66), Firmicutes bacterium CAG:534 (R7AVK7)
Manually annotated by BRENDA team
Krewinkel, M.; Gosch, M.; Rentschler, E.; Fischer, L.
Epilactose production by 2 cellobiose 2-epimerases in natural milk
J. Dairy Sci.
97
155-161
2014
Flavobacterium johnsoniae (A5FA14), Pedobacter heparinus (C6XVU9), Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 (C6XVU9), Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101 (A5FA14)
Manually annotated by BRENDA team
Krewinkel, M.; Kaiser, J.; Merz, M.; Rentschler, E.; Kuschel, B.; Hinrichs, J.; Fischer, L.
Novel cellobiose 2-epimerases for the production of epilactose from milk ultrafiltrate containing lactose
J. Dairy Sci.
98
3665-3678
2015
Cellulosilyticum lentocellum (F2JR71), Dysgonomonas gadei (F5ITJ6), Cellulosilyticum lentocellum ATCC 49066 / DSM 5427 / NCIMB 11756 / RHM5 (F2JR71), Dysgonomonas gadei ATCC BAA-286 (F5ITJ6)
Manually annotated by BRENDA team
Chen, Q.; Zhang, W.; Zhang, T.; Jiang, B.; Mu, W.
Characterization of an epilactose-producing cellobiose 2-epimerase from Thermoanaerobacterium saccharolyticum
J. Mol. Catal. B
116
39-44
2015
Thermoanaerobacterium saccharolyticum (I3VXT6), Thermoanaerobacterium saccharolyticum JW/SL-YS485 / DSM 8691 (I3VXT6)
-
Manually annotated by BRENDA team
Shen, Q.; Zhang, Y.; Yang, R.; Hua, X.; Zhang, W.; Zhao, W.
Thermostability enhancement of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus by site-directed mutagenesis
J. Mol. Catal. B
120
158-164
2015
Caldicellulosiruptor saccharolyticus (A4XGA6)
-
Manually annotated by BRENDA team
Kuschel, B.; Claaßen, W.; Mu, W.; Jiang, B.; Stressler, T.; Fischer, L.
Reaction investigation of lactulose-producing cellobiose 2-epimerases under operational relevant conditions
J. Mol. Catal. B
133
S80-S87
2016
Caldicellulosiruptor saccharolyticus (A4XGA6), Dictyoglomus turgidum (B8DZK4), Dictyoglomus turgidum DSM 6724 (B8DZK4)
-
Manually annotated by BRENDA team
Chen, Q.; Levin, R.; Zhang, W.; Zhang, T.; Jiang, B.; Stressler, T.; Fischer, L.; Mu, W.
Characterisation of a novel cellobiose 2-epimerase from thermophilic Caldicellulosiruptor obsidiansis for lactulose production
J. Sci. Food. Agric.
97
3095-3105
2017
Caldicellulosiruptor obsidiansis (D9TH31), Caldicellulosiruptor obsidiansis, Caldicellulosiruptor obsidiansis ATCC BAA-2073 / strain OB47 (D9TH31)
Manually annotated by BRENDA team
Park, A.R.; Kim, J.S.; Jang, S.W.; Park, Y.G.; Koo, B.S.; Lee, H.C.
Rational modification of substrate binding site by structure-based engineering of a cellobiose 2-epimerase in Caldicellulosiruptor saccharolyticus
Microb. Cell Fact.
16
224
2017
Caldicellulosiruptor saccharolyticus (A4XGA6), Caldicellulosiruptor saccharolyticus, Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331 (A4XGA6)
Manually annotated by BRENDA team
Park, A.; Koo, B.; Kim, J.; Kim, E.; Lee, H.
Lactulose production using immobilized cells including thermostable cellobiose 2-epimerase
Microbiol. Biotechnol. Lett.
44
504-511
2016
Caldicellulosiruptor saccharolyticus (A4XGA6)
-
Manually annotated by BRENDA team