5.1.3.11: cellobiose epimerase

This is an abbreviated version!
For detailed information about cellobiose epimerase, go to the full flat file.

Reaction

Synonyms

B15CE, BfCE, BN699_02313, Caob-CE, CE-NE1, ce13, cellobiose 2-epimerase, CS-HRCE, Csac_0294, CsCE, CvCE, DfCE, Dfer_1975, DsCE, DtCE, Dtur_0652, EcCE, EpiA, epilactose-producing cellobiose 2-epimerase, Epimerase, cellobiose, FbCE, FjCE, Fjoh_4956, HaCE, Haur_0887, mannobiose 2-epimerase, md1, md2, PhCE, Phep_3983, RACE, Rmar_2439, RmCE, SdCE, Sde_0508, SlCE, Slin_0271, Spith_0082, StCE, STHERM_c00950, TERTU_4095, Thsa-CE, TtCE

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.11 cellobiose epimerase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	Activating Compound
2155	AA Sequence
59	Application
1	CAS Registry Number
56	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
68	General Information
16	Inhibitors
103	kcat/KM [mM/s]
112	KM Value [mM]
2	Metals/Ions
16	Molecular Weight [Da]
113	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
114	Organism
1	Pathway
17	PDB ID
50	pH Optimum
9	pH Range
13	pH Stability
1	pI Value
97	Protein Variants
35	Purification (Commentary)
32	Reaction
6	Reaction Type
89	Reference
80	Specific Activity [micromol/min/mg]
327	Substrates and Products (Substrate)
35	Subunits
179	Synonyms
1	Systematic Name
59	Temperature Optimum [°C]
5	Temperature Range [°C]
37	Temperature Stability [°C]
107	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 5.1.3.11 - cellobiose epimerase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 lactulose

lactose + epilactose

3 entries

4-O-beta-D-mannopyranosyl-beta-D-mannopyranose

4-O-beta-D-mannopyranosyl-D-glucose

2 entries

4-O-beta-D-mannopyranosyl-D-mannose

4-O-beta-D-glucopyranosyl-D-mannose

Rhodothermus marinus

F8WRK9

-

727985

-

-

r

beta-1,4-mannobiose

4-O-beta-D-mannopyranosyl-D-glucose

2 entries

beta-mannobiose

4-O-beta-D-mannopyranosyl-D-glucose

Bacteroides fragilis

Q5LH66

-

702762

putative product

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

40 entries

cellobiose

D-glucosyl-D-mannose

4 entries

globotriose

O-alpha-D-galactopyranosyl-(1,4)-O-beta-D-galactopyranosyl-(1,4)-D-mannose

Bacteroides fragilis

Q5LH66

-

702762

putative product

-

r

lactose

4-O-beta-D-galactopyranosyl-D-mannose

3 entries

lactose

epilactose

29 entries

lactose

lactulose

15 entries

additional information

?

-

9 entries

2 lactulose

lactose + epilactose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

748417

-

-

r

2 lactulose

lactose + epilactose

Dictyoglomus turgidum

B8DZK4

-

748417

-

-

r

2 lactulose

lactose + epilactose

Dictyoglomus turgidum DSM 6724

B8DZK4

-

748417

-

-

r

4-O-beta-D-mannopyranosyl-beta-D-mannopyranose

4-O-beta-D-mannopyranosyl-D-glucose

Cellvibrio vulgaris

-

-

747317

-

-

r

4-O-beta-D-mannopyranosyl-beta-D-mannopyranose

4-O-beta-D-mannopyranosyl-D-glucose

Cellvibrio vulgaris NCIMB8633

-

-

747317

-

-

r

beta-1,4-mannobiose

4-O-beta-D-mannopyranosyl-D-glucose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

748593

-

-

r

beta-1,4-mannobiose

4-O-beta-D-mannopyranosyl-D-glucose

Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331

A4XGA6

-

748593

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Bacteroides fragilis

Q5LH66

-

702762, 747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Bacteroides fragilis ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343

Q5LH66

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor obsidiansis

D9TH31

-

748500

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor obsidiansis ATCC BAA-2073 / strain OB47

D9TH31

-

748500

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

747318, 747812

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor saccharolyticus

-

-

747812

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

748593

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331

A4XGA6

-

747318, 748593

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Cellulosilyticum lentocellum

F2JR71

-

748299

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Cellulosilyticum lentocellum ATCC 49066 / DSM 5427 / NCIMB 11756 / RHM5

F2JR71

-

748299

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Cellvibrio vulgaris

-

-

747317, 747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Cellvibrio vulgaris NCIMB8633

-

-

747317

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dictyoglomus turgidum

B8DZK4

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dictyoglomus turgidum Z-1310 / DSM 6724

B8DZK4

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dyadobacter fermentans

C6VW66

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114

C6VW66

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dysgonomonas gadei

F5ITJ6

-

748299

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Dysgonomonas gadei ATCC BAA-286

F5ITJ6

-

748299

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Flavobacterium johnsoniae

A5FA14

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101

A5FA14

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Herpetosiphon aurantiacus

A9AYF3

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Herpetosiphon aurantiacus ATCC 23779 / DSM 785

A9AYF3

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Pedobacter heparinus

C6XVU9

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3

C6XVU9

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Rhodothermus marinus

F8WRK9

-

727985, 747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Ruminococcus albus

-

-

714526

-

-

?

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Ruminococcus albus

P0DKY4

-

702762, 747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Ruminococcus albus

P0DKY4

cellobiose 2-epimerase catalyzes a hydroxyl stereoisomerism at C-2 of the reducing terminal glucose moiety

702816

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Ruminococcus albus NE1

-

-

714526

-

-

?

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Saccharophagus degradans

Q21NF7

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Saccharophagus degradans 2-40 / ATCC 43961 / DSM 17024

Q21NF7

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Spirochaeta thermophila

E0RU15, G0GBL0

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Spirochaeta thermophila ATCC 49972 / DSM 6192 / RI 19.B1

E0RU15

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Spirochaeta thermophila ATCC 700085 / DSM 6578 / Z-1203

G0GBL0

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Spirosoma linguale

D2QDA5

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Spirosoma linguale ATCC 33905 / DSM 74 / LMG 10896

D2QDA5

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Teredinibacter turnerae

C5BUF0, K7ZLA5

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

Teredinibacter turnerae ATCC 39867 / T7901

C5BUF0

-

747318

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

uncultured bacterium

A0A0A1H8D7, A0A0A1HAT7

-

746891

-

-

r

cellobiose

4-O-beta-D-glucopyranosyl-D-mannose

[Eubacterium] cellulosolvens

B3XZI5

-

747318

-

-

r

cellobiose

D-glucosyl-D-mannose

Dictyoglomus turgidum

-

-

727227

-

-

?

cellobiose

D-glucosyl-D-mannose

Dictyoglomus turgidum DSM 6724

-

-

727227

-

-

?

cellobiose

D-glucosyl-D-mannose

Rhodothermus marinus

F8WRK9

-

727191

-

-

r

cellobiose

D-glucosyl-D-mannose

Rhodothermus marinus JCM 9785

F8WRK9

-

727191

-

-

r

lactose

4-O-beta-D-galactopyranosyl-D-mannose

Bacteroides fragilis

Q5LH66

-

702762

-

-

r

lactose

4-O-beta-D-galactopyranosyl-D-mannose

Ruminococcus albus

P0DKY4

-

702762

-

-

r

lactose

4-O-beta-D-galactopyranosyl-D-mannose

Ruminococcus albus

P0DKY4

-

702816

epilactose

-

r

lactose

epilactose

Bacteroides fragilis

Q5LH66

-

748009

-

-

r

lactose

epilactose

Bacteroides fragilis DSM 2151

Q5LH66

-

748009

-

-

r

lactose

epilactose

Butyrivibrio sp. AE2015

-

-

748009

-

-

r

lactose

epilactose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

747300, 748593

-

-

r

lactose

epilactose

Caldicellulosiruptor saccharolyticus

-

-

748593

-

-

r

lactose

epilactose

Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331

A4XGA6

-

747300, 748593

-

-

r

lactose

epilactose

Cellulosilyticum lentocellum

F2JR71

-

748299

-

-

r

lactose

epilactose

Cellulosilyticum lentocellum ATCC 49066 / DSM 5427 / NCIMB 11756 / RHM5

F2JR71

-

748299

-

-

r

lactose

epilactose

Cellvibrio vulgaris

-

-

747317

-

-

r

lactose

epilactose

Cellvibrio vulgaris NCIMB8633

-

-

747317

-

-

r

lactose

epilactose

Dyadobacter fermentans

C6VW66

-

748009

-

-

r

lactose

epilactose

Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114

C6VW66

-

748009

-

-

r

lactose

epilactose

Dysgonomonas gadei

F5ITJ6

-

748299

-

-

r

lactose

epilactose

Dysgonomonas gadei ATCC BAA-286

F5ITJ6

-

748299

-

-

r

lactose

epilactose

Firmicutes bacterium

R7AVK7

-

748009

-

-

r

lactose

epilactose

Firmicutes bacterium CAG:534

R7AVK7

-

748009

-

-

r

lactose

epilactose

Flavobacterium johnsoniae

A5FA14

-

748298

-

-

r

lactose

epilactose

Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101

A5FA14

-

748298

-

-

r

lactose

epilactose

Pedobacter heparinus

C6XVU9

-

748298

-

-

r

lactose

epilactose

Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3

C6XVU9

-

748298

-

-

r

lactose

epilactose

Rhodothermus marinus

D0MF61, F8WRK9

-

748009

-

-

r

lactose

epilactose

Rhodothermus marinus

F8WRK9

-

727193, 727985

-

-

r

lactose

epilactose

Rhodothermus marinus

-

-

727985

-

-

r

lactose

epilactose

Rhodothermus marinus ATCC 43812 / DSM 4252 / R-10

D0MF61

-

748009

-

-

r

lactose

epilactose

Rhodothermus marinus JCM 9785

F8WRK9

-

727193

-

-

r

lactose

epilactose

Ruminococcus albus

P0DKY4

-

748009

-

-

r

lactose

epilactose

Ruminococcus albus DSM 20455

P0DKY4

-

748009

-

-

r

lactose

epilactose

Thermoanaerobacterium saccharolyticum

I3VXT6

-

748409

-

-

r

lactose

epilactose

Thermoanaerobacterium saccharolyticum JW/SL-YS485 / DSM 8691

I3VXT6

-

748409

-

-

r

lactose

lactulose

Bacteroides fragilis

Q5LH66

-

748009

-

-

r

lactose

lactulose

Bacteroides fragilis DSM 2151

Q5LH66

-

748009

-

-

r

lactose

lactulose

Butyrivibrio sp. AE2015

-

-

748009

-

-

r

lactose

lactulose

Caldicellulosiruptor obsidiansis

D9TH31

when lactose is used as substrate, epilactose is rapidly produced in a short period, and afterwards both epilactose and lactose are steadily isomerised to lactulose, with a final ratio of 35:11:54 for lactose:epilactose:lactulose

748500

-

-

r

lactose

lactulose

Caldicellulosiruptor obsidiansis ATCC BAA-2073 / strain OB47

D9TH31

when lactose is used as substrate, epilactose is rapidly produced in a short period, and afterwards both epilactose and lactose are steadily isomerised to lactulose, with a final ratio of 35:11:54 for lactose:epilactose:lactulose

748500

-

-

r

lactose

lactulose

Caldicellulosiruptor saccharolyticus

A4XGA6

-

747970, 748411

-

-

r

lactose

lactulose

Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331

A4XGA6

-

747970

-

-

r

lactose

lactulose

Dyadobacter fermentans

C6VW66

-

748009

-

-

r

lactose

lactulose

Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114

C6VW66

-

748009

-

-

r

lactose

lactulose

Firmicutes bacterium

R7AVK7

-

748009

-

-

r

lactose

lactulose

Firmicutes bacterium CAG:534

R7AVK7

-

748009

-

-

r

lactose

lactulose

Rhodothermus marinus

D0MF61, F8WRK9

-

748009

-

-

r

lactose

lactulose

Rhodothermus marinus ATCC 43812 / DSM 4252 / R-10

D0MF61

-

748009

-

-

r

lactose

lactulose

Ruminococcus albus

P0DKY4

-

748009

-

-

r

lactose

lactulose

Ruminococcus albus DSM 20455

P0DKY4

-

748009

-

-

r

additional information

?

-

Bacteroides fragilis

Q5LH66

recombinant enzyme catalyzes a hydroxyl stereoisomerism at the C2-positions of the reducing terminal glucose and at the mannose moiety of cello-oligosaccharides: lactose, beta-mannobiose and globotriose

702762

-

-

?

additional information

?

-

Bacteroides fragilis

-

recombinant enzyme catalyzes a hydroxyl stereoisomerism at the C2-positions of the reducing terminal glucose and at the mannose moiety of cello-oligosaccharides: lactose, beta-mannobiose and globotriose

702762

-

-

?

additional information

?

-

Rhodothermus marinus

F8WRK9

cellobiose 2-epimerase reversibly converts alpha-glucose residue to alpha-mannose residue at the reducing end of beta-1,4-linked oligosaccharides

727191

-

-

?

additional information

?

-

Rhodothermus marinus

-

cellobiose 2-epimerase reversibly converts alpha-glucose residue to alpha-mannose residue at the reducing end of beta-1,4-linked oligosaccharides

727191

-

-

?

additional information

?

-

Rhodothermus marinus

F8WRK9

cellobiose 2-epimerase reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified beta-1,4-linked oligosaccharides, including beta-1,4-mannobiose, cellobiose, and lactose

727985

-

-

?

additional information

?

-

Rhodothermus marinus

-

cellobiose 2-epimerase reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified beta-1,4-linked oligosaccharides, including beta-1,4-mannobiose, cellobiose, and lactose

727985

-

-

?

additional information

?

-

Rhodothermus marinus JCM 9785

F8WRK9

cellobiose 2-epimerase reversibly converts alpha-glucose residue to alpha-mannose residue at the reducing end of beta-1,4-linked oligosaccharides

727191

-

-

?

additional information

?

-

Rhodothermus marinus JCM 9785

-

cellobiose 2-epimerase reversibly converts alpha-glucose residue to alpha-mannose residue at the reducing end of beta-1,4-linked oligosaccharides

727191

-

-

?

additional information

?

-

Ruminococcus albus

-

cellobiose 2-epimerase catalyzes interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked oligosaccharides

727529

-

-

?