5.1.3.11: cellobiose epimerase
This is an abbreviated version!
For detailed information about cellobiose epimerase, go to the full flat file.
Word Map on EC 5.1.3.11
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5.1.3.11
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synthesis
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epimerization
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lactulose
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caldicellulosiruptor
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saccharolyticus
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isomerization
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d-glucose
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ruminococcus
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albus
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prebiotic
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d-mannose
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marinus
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turgidum
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rhodothermus
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nutrition
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dictyoglomus
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mannans
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food industry
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n-acyl-d-glucosamine
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epimerizes
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isomerizes
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cello-oligosaccharides
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spirochaeta
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pharmacology
- 5.1.3.11
- synthesis
-
epimerization
- lactulose
- caldicellulosiruptor
- saccharolyticus
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isomerization
- d-glucose
- ruminococcus
- albus
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prebiotic
- d-mannose
- marinus
- turgidum
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rhodothermus
- nutrition
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dictyoglomus
- mannans
- food industry
- n-acyl-d-glucosamine
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epimerizes
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isomerizes
- cello-oligosaccharides
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spirochaeta
- pharmacology
Reaction
Synonyms
B15CE, BfCE, BN699_02313, Caob-CE, CE-NE1, ce13, cellobiose 2-epimerase, CS-HRCE, Csac_0294, CsCE, CvCE, DfCE, Dfer_1975, DsCE, DtCE, Dtur_0652, EcCE, EpiA, epilactose-producing cellobiose 2-epimerase, Epimerase, cellobiose, FbCE, FjCE, Fjoh_4956, HaCE, Haur_0887, mannobiose 2-epimerase, md1, md2, PhCE, Phep_3983, RACE, Rmar_2439, RmCE, SdCE, Sde_0508, SlCE, Slin_0271, Spith_0082, StCE, STHERM_c00950, TERTU_4095, Thsa-CE, TtCE
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5.1.3.11 cellobiose epimeraseAdvanced search results
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results (General Information
General Information on EC 5.1.3.11 - cellobiose epimerase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
metabolism
the enzyme is responsible for conversion of beta-1,4-mannobiose to 4-O-beta-D-mannosyl-D-glucose in mannan metabolism
physiological function
additional information
evolution
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structure, active site, and reaction mechanism of cellobiose 2-epimerase are similar to those of N-acyl-D-glucosamine 2-epimerase
evolution
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the structure of RaCE shows strong similarity to those of N-acetyl-D-glucosamine 2-epimerase and aldose-ketose isomerase YihS with a high degree of conservation of residues around the catalytic center, although sequence identity between them is low
evolution
the cluster of CE and CE-like proteins is functionally and evolutionarily separated from that of N-acetyl-D-glucosamine 2-epimerase (AGE) and AGE-like proteins, phylogenetic analysis
evolution
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structure, active site, and reaction mechanism of cellobiose 2-epimerase are similar to those of N-acyl-D-glucosamine 2-epimerase
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physiological function
Caldicellulosiruptor saccharolyticus cellobiose 2-epimerase (CsCE) catalyses the single substrate lactose into lactulose and is a highly efficient enzyme for the enzymatic synthesis of lactulose
physiological function
cellobiose 2-epimerase from the thermophile Caldicellulosiruptor saccharolyticus (CsCE) catalyzes the isomerization of lactose into lactulose, a non-digestible disaccharide widely used in food and pharmaceutical industries
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
physiological function
the enzyme reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified beta-1,4-linked oligosaccharides, including beta-1,4-mannobiose, cellobiose, and lactose
physiological function
Bacteroides fragilis ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Spirochaeta thermophila ATCC 49972 / DSM 6192 / RI 19.B1
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
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physiological function
Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331
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Caldicellulosiruptor saccharolyticus cellobiose 2-epimerase (CsCE) catalyses the single substrate lactose into lactulose and is a highly efficient enzyme for the enzymatic synthesis of lactulose
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physiological function
Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331
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the enzyme reversibly converts D-glucose residues into D-mannose residues at the reducing end of unmodified beta-1,4-linked oligosaccharides, including beta-1,4-mannobiose, cellobiose, and lactose
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physiological function
Herpetosiphon aurantiacus ATCC 23779 / DSM 785
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
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physiological function
Spirosoma linguale ATCC 33905 / DSM 74 / LMG 10896
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Saccharophagus degradans 2-40 / ATCC 43961 / DSM 17024
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Teredinibacter turnerae ATCC 39867 / T7901
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Dictyoglomus turgidum Z-1310 / DSM 6724
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physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
physiological function
Spirochaeta thermophila ATCC 700085 / DSM 6578 / Z-1203
-
physiological function of cellobiose 2-epimerase in carbohydrate metabolism, overview
-
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
enzyme structure-function relationship, overview
additional information
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enzyme structure-function relationship, overview
additional information
determination of residues involved in substrate recognition, overview
additional information
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determination of residues involved in substrate recognition, overview
additional information
three-dimensional structure and substrate binding structure analysis, residues Tyr114 and Asn184 play an important role in binding epilactose, overview. The active site, with its triple histidine center, is located inside the (alpha/alpha)6 barrel structure of the catalytic domain. Two essential conserved histidine residues, His247 and His377, and a third histidine residue located at the bottom of the substrate binding site are required for catalysis. Y114 and N184 in the catalyt domain are located at the interface of the mannose moiety of epilactose in the enzyme-product complex
additional information
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three-dimensional structure and substrate binding structure analysis, residues Tyr114 and Asn184 play an important role in binding epilactose, overview. The active site, with its triple histidine center, is located inside the (alpha/alpha)6 barrel structure of the catalytic domain. Two essential conserved histidine residues, His247 and His377, and a third histidine residue located at the bottom of the substrate binding site are required for catalysis. Y114 and N184 in the catalyt domain are located at the interface of the mannose moiety of epilactose in the enzyme-product complex
additional information
three-dimensional structure, structure modeling
additional information
Bacteroides fragilis ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343
-
enzyme structure-function relationship, overview
-
additional information
Spirochaeta thermophila ATCC 49972 / DSM 6192 / RI 19.B1
-
enzyme structure-function relationship, overview
-
additional information
Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331
-
enzyme structure-function relationship, overview
-
additional information
Caldicellulosiruptor saccharolyticus ATCC 43494 / DSM 8903 / Tp8T 6331
-
three-dimensional structure and substrate binding structure analysis, residues Tyr114 and Asn184 play an important role in binding epilactose, overview. The active site, with its triple histidine center, is located inside the (alpha/alpha)6 barrel structure of the catalytic domain. Two essential conserved histidine residues, His247 and His377, and a third histidine residue located at the bottom of the substrate binding site are required for catalysis. Y114 and N184 in the catalyt domain are located at the interface of the mannose moiety of epilactose in the enzyme-product complex
-
additional information
Herpetosiphon aurantiacus ATCC 23779 / DSM 785
-
enzyme structure-function relationship, overview
-
additional information
Spirosoma linguale ATCC 33905 / DSM 74 / LMG 10896
-
enzyme structure-function relationship, overview
-
additional information
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3
-
enzyme structure-function relationship, overview
-
additional information
Saccharophagus degradans 2-40 / ATCC 43961 / DSM 17024
-
enzyme structure-function relationship, overview
-
additional information
Teredinibacter turnerae ATCC 39867 / T7901
-
enzyme structure-function relationship, overview
-
additional information
Dyadobacter fermentans ATCC 700827 / DSM 18053 / NS114
-
enzyme structure-function relationship, overview
-
additional information
Flavobacterium johnsoniae ATCC 17061 / DSM 2064 / UW101
-
enzyme structure-function relationship, overview
-
additional information
Dictyoglomus turgidum Z-1310 / DSM 6724
-
enzyme structure-function relationship, overview
-
additional information
Spirochaeta thermophila ATCC 700085 / DSM 6578 / Z-1203
-
enzyme structure-function relationship, overview
-
