5.1.2.7: tagaturonate epimerase
This is an abbreviated version!
For detailed information about tagaturonate epimerase, go to the full flat file.
Reaction
Synonyms
fructuronate epimerase, tagaturonate/fructuronate epimerase, Tm0440, UxaE
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Substrates Products
Substrates Products on EC 5.1.2.7 - tagaturonate epimerase
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REACTION DIAGRAM
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residue Asp161 likely interacts with the C3 hydroxyl group of D-TagA and deprotonates it. A divalent cation (likely Zn2+) chelated by His162 and possibly interacts with the C5 keto and C4 hydroxyl groups of D-TagA, thereby contributing to the cleavage of the adjacent C3-C4 bond. A carboxyl group of Glu266 then may promote the rotation and reprotonation of the C3 aldehyde group in the intermediate and the restoration of the broken C3-C4 bond to form D-FruA
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additional information
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residue Asp161 likely interacts with the C3 hydroxyl group of D-TagA and deprotonates it. A divalent cation (likely Zn2+) chelated by His162 and possibly interacts with the C5 keto and C4 hydroxyl groups of D-TagA, thereby contributing to the cleavage of the adjacent C3-C4 bond. A carboxyl group of Glu266 then may promote the rotation and reprotonation of the C3 aldehyde group in the intermediate and the restoration of the broken C3-C4 bond to form D-FruA
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