5.1.2.3: 3-hydroxybutyryl-CoA epimerase

This is an abbreviated version!
For detailed information about 3-hydroxybutyryl-CoA epimerase, go to the full flat file.

Reaction

Synonyms

3-Hydroxyacyl-coenzyme A epimerase, 3-Hydroxybutyryl coenzyme A epimerase, Epimerase, 3-hydroxybutyryl coenzyme A, TFP

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.2 Acting on hydroxy acids and derivatives

                5.1.2.3 3-hydroxybutyryl-CoA epimerase

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Results	in table
7121	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Cofactor
1	Inhibitors
8	Localization
16	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
380	Organism
5	Pathway
13	PDB ID
4	Posttranslational Modification
1	Protein Variants
10	Purification (Commentary)
6	Reaction
1	Reaction Type
30	Reference
8	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
15	Substrates and Products (Substrate)
8	Subunits
4	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 5.1.2.3 - 3-hydroxybutyryl-CoA epimerase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

D-3-Hydroxy-4-trans-decenoyl-CoA

L3-Hydroxy-4-trans-decenoyl-CoA

Escherichia coli

-

-

2214

-

2214

?

D-3-Hydroxydodecanoyl-CoA

L-3-Hydroxydodecanoyl-CoA

2 entries

D-3-hydroxyoctanoly-CoA

L-3-hydroxyoctanoyl-CoA

3 entries

additional information

?

-

4 entries

D-3-Hydroxydodecanoyl-CoA

L-3-Hydroxydodecanoyl-CoA

Escherichia coli

-

-

2206, 2207, 2209, 2962

-

-

?

D-3-Hydroxydodecanoyl-CoA

L-3-Hydroxydodecanoyl-CoA

Escherichia coli B / ATCC 11303

-

-

2207, 2962, 2209

-

-

?

D-3-hydroxyoctanoly-CoA

L-3-hydroxyoctanoyl-CoA

Escherichia coli

-

-

2210

-

-

?

D-3-hydroxyoctanoly-CoA

L-3-hydroxyoctanoyl-CoA

Pseudomonas fragi

-

-

2213

-

-

?

D-3-hydroxyoctanoly-CoA

L-3-hydroxyoctanoyl-CoA

Rattus norvegicus

-

-

2211

-

-

?

additional information

?

-

Gram-negative bacteria

-

-

2215

-

-

?

additional information

?

-

Mammalia

-

3-hydroxyacyl-CoA epimerase activity as a part of a system capable of degrading products formed as a result of Gram-negative bacterial infections. In addition the enzyme may play a role in the metabolism of leukotrienes, specifically 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid, i.e. the 5-lipoxygenase oxidation product of arachidonic acid

2215

-

-

?

additional information

?

-

Rattus norvegicus

-

-

2215

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme may not be involved in the beta-oxidation of unsaturated fatty acids at all

2212

-

-

?