Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

5.1.2.1: lactate racemase

This is an abbreviated version!
For detailed information about lactate racemase, go to the full flat file.

Word Map on EC 5.1.2.1

Reaction

(S)-lactate
=
(R)-lactate

Synonyms

Hydroxyacid racemase, lactate racemase, Lactic acid racemase, Lacticoracemase, LAR, LARa, nickel-dependent lactate racemase, Racemase, lactate

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.2 Acting on hydroxy acids and derivatives
                5.1.2.1 lactate racemase

Reference

topprint

Reference on EC 5.1.2.1 - lactate racemase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Melville, S.B.; Michel, T.A.; Macy, J.M.
Involvement of D-lactate and lactic acid racemase in the metabolism of glucose by Selenomonas ruminantium
FEMS Microbiol. Lett.
40
289-293
1987
Selenomonas ruminantium
-
Manually annotated by BRENDA team
Pepple, J.S.; Dennis, D.
Lactate racemase. Hydroxylamine-dependent 18O exchange of the alpha-hydroxyl of lactic acid
Biochim. Biophys. Acta
429
1036-1040
1976
Clostridium butyricum
Manually annotated by BRENDA team
Cantwell, A.; Dennis, D.
Lactate racemase. Direct evidence for an alpha-carbonyl intermediate
Biochemistry
13
287-291
1974
Clostridium butyricum
Manually annotated by BRENDA team
Stetter, K.O.; Kandler, O.
Untersuchungen zur Entstehung von DL-Milchsäure bei Lactobacillen und Charakterisierung einer Milchsäureracemase bei einigen Arten der Untergattung Streptobacterium
Arch. Microbiol.
94
221-247
1973
Lacticaseibacillus casei, Latilactobacillus curvatus, Latilactobacillus sakei
Manually annotated by BRENDA team
Hiyama, T.; Fukui, S.; Kitahara, K.
Purification and properties of lactate racemase from Lactobacillus sake
J. Biochem.
64
99-107
1968
Latilactobacillus sakei
Manually annotated by BRENDA team
Melville, S.B.; Michel, T.A.; Macy, J.M.
Pathway and sites for energy conservation in the metabolism of glucose by Selenomonas ruminantium
J. Bacteriol.
170
5298-5304
1988
Selenomonas ruminantium, Selenomonas ruminantium HD4
Manually annotated by BRENDA team
Hino, T.M.; Kuroda, S.
Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate
Appl. Environ. Microbiol.
59
255-259
1993
Megasphaera elsdenii
Manually annotated by BRENDA team
Oren, A.; Gurevich, P.
Diversity of lactate metabolism in halophilic archaea
Can. J. Microbiol.
41
302-307
1995
Haloarcula marismortui, Haloarcula vallismortis, Haloferax volcanii, no activity in Halobacterium saccharovorum, no activity in Halobacterium salinarum, no activity in Haloferax mediterranei
Manually annotated by BRENDA team
Goffin, P.; Deghorain, M.; Mainardi, J.L.; Tytgat, I.; Champomier-Verges, M.C.; Kleerebezem, M.; Hols, P.
Lactate racemization as a rescue pathway for supplying D-lactate to the cell wall biosynthesis machinery in Lactobacillus plantarum
J. Bacteriol.
187
6750-6761
2005
Lactiplantibacillus plantarum
Manually annotated by BRENDA team
Desguin, B.; Goffin, P.; Viaene, E.; Kleerebezem, M.; Martin-Diaconescu, V.; Maroney, M.; Declercq, J.; Soumillion, P.; Hols, P.
Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system
Nat. Commun.
5
3615
2014
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team
Rankin, J.A.; Mauban, R.C.; Fellner, M.; Desguin, B.; McCracken, J.; Hu, J.; Varganov, S.A.; Hausinger, R.P.
Lactate racemase nickel-pincer cofactor operates by a proton-coupled hydride transfer mechanism
Biochemistry
57
3244-3251
2018
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team
Okano, K.; Uematsu, G.; Hama, S.; Tanaka, T.; Noda, H.; Kondo, A.; Honda, K.
Metabolic engineering of Lactobacillus plantarum for direct L-lactic acid production from raw corn starch
Biotechnol. J.
13
e1700517
2018
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team
Zhang, X.; Chung, L.W.
Alternative mechanistic strategy for enzyme catalysis in a Ni-dependent lactate racemase (LarA) intermediate destabilization by the cofactor
Chemistry
23
3623-3630
2017
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team
Desguin, B.; Goffin, P.; Bakouche, N.; Diman, A.; Viaene, E.; Dandoy, D.; Fontaine, L.; Hallet, B.; Hols, P.
Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum
J. Bacteriol.
197
219-230
2015
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team
Desguin, B.; Zhang, T.; Soumillion, P.; Hols, P.; Hu, J.; Hausinger, R.
A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase
Science
349
66-69
2015
Lactiplantibacillus plantarum (F9USS9), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (F9USS9)
Manually annotated by BRENDA team