5.1.2.1: lactate racemase
This is an abbreviated version!
For detailed information about lactate racemase, go to the full flat file.
Word Map on EC 5.1.2.1
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5.1.2.1
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lactobacillus
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plantarum
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racemization
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pincer
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hydride
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organometallic
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nickel-containing
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proton-coupled
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nife-hydrogenase
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sacrificial
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insertase
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ni-dependent
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sakei
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pyridinium
- 5.1.2.1
- lactobacillus
- plantarum
-
racemization
-
pincer
-
hydride
-
organometallic
-
nickel-containing
-
proton-coupled
- nife-hydrogenase
-
sacrificial
-
insertase
-
ni-dependent
- sakei
-
pyridinium
Reaction
Synonyms
Hydroxyacid racemase, lactate racemase, Lactic acid racemase, Lacticoracemase, LAR, LARa, nickel-dependent lactate racemase, Racemase, lactate
ECTree
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Reaction
Reaction on EC 5.1.2.1 - lactate racemase
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direct internal hydride transfer mechanism, symmetrical alpha-carbon intermediate
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(S)-Lactate = (R)-lactate
transient carbonyl intermediate, carbonyl is in the alpha-position of the enzyme-bound lactic acid
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(S)-Lactate = (R)-lactate
the enzyme does not follow a proton-coupled electron transfer mechanism, but a proton-coupled hydride transfer (PCHT) mechanism. The nickel-pincer cofactor facilitates a proton-coupled hydride transfer (PCHT) mechanism during LarA-catalyzed lactate racemization
(S)-Lactate = (R)-lactate
the Ni-tethered pincer cofactor in enzyme LarA increases reaction barriers and destabilizes NADH-like pyruvate intermediates, due to the less electrophilic Ni cofactor and to the ring strain in the pyruvate intermediates, reaction mechanism, active and transition state structure, modeling
(S)-Lactate = (R)-lactate
the enzyme does not follow a proton-coupled electron transfer mechanism, but a proton-coupled hydride transfer (PCHT) mechanism. The nickel-pincer cofactor facilitates a proton-coupled hydride transfer (PCHT) mechanism during LarA-catalyzed lactate racemization
Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1
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(S)-Lactate = (R)-lactate
the Ni-tethered pincer cofactor in enzyme LarA increases reaction barriers and destabilizes NADH-like pyruvate intermediates, due to the less electrophilic Ni cofactor and to the ring strain in the pyruvate intermediates, reaction mechanism, active and transition state structure, modeling
Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1
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