5.1.1.8: 4-hydroxyproline epimerase

This is an abbreviated version!
For detailed information about 4-hydroxyproline epimerase, go to the full flat file.

Word Map on EC 5.1.1.8

5.1.1.8

trans-4-hydroxy-l-proline

racemase

d-amino

brucella

sinorhizobium

abortus

d-proline

hypd

analysis

semialdehyde

epimerization

meliloti

cis-4-hydroxy-d-proline

medicine

molecular biology

Reaction

Synonyms

4-hydroxyproline 2-epimerase, 4-hydroxyproline-2-epimerase, AbLhpA, BaHyPRE, Epimerase, hydroxyproline, FaProR, Hydroxyproline 2-epimerase, Hydroxyproline epimerase, HypE, HyPRE, L-Hydroxyproline epimerase, proline racemase/hydroxyproline epimerase, ProR/HypE, PrpA, Smb20268

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.8 4-hydroxyproline epimerase

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Results	in table
1	Activating Compound
2372	AA Sequence
6	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Cofactor
3	Expression
9	General Information
3	IC50 Value
28	Inhibitors
13	kcat/KM [mM/s]
36	KM Value [mM]
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
21	Organism
3	Pathway
4	pH Optimum
7	Protein Variants
9	Purification (Commentary)
4	Reaction
1	Reaction Type
21	Reference
1	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
41	Substrates and Products (Substrate)
4	Subunits
27	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

KM Value

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KM Value on EC 5.1.1.8 - 4-hydroxyproline epimerase

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24 - 42

2-2H-4-allohydroxy-D-Pro

2-2H-4-hydroxy-L-Pro

solvent H2O

3-allohydroxy-D-Pro

solvent 2H2O

3-allohydroxy-L-Pro

solvent H2O

3-Hydroxy-L-Pro

solvent H2O

4-allohydroxy-D-Pro

solvent H2O

4-allohydroxy-L-Pro

solvent H2O

13 - 14

4-hydroxy-L-Pro

3 entries

allohydroxy-L-Pro

Pseudomonas putida

2156

3.14 - 8

cis-4-hydroxy-D-proline

5 entries

hydroxy-L-Pro

Pseudomonas putida

2156

0.502 - 16.4

trans-3-hydroxy-L-proline

2 entries

0.0016

trans-4-hydroxy-D-proline

Pseudomonas aeruginosa

in 50 mM HEPES, pH 8.0, with 2 mM beta-mercaptoethanol,1 mM EDTA, at 37°C

714823

7.6 - 14.4

trans-4-hydroxy-L-Pro

5 entries

0.0024 - 10

trans-4-hydroxy-L-proline

9 entries

additional information

Sinorhizobium meliloti

Michaelis-Menten kinetics

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