5.1.1.8: 4-hydroxyproline epimerase
This is an abbreviated version!
For detailed information about 4-hydroxyproline epimerase, go to the full flat file.
Word Map on EC 5.1.1.8
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5.1.1.8
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trans-4-hydroxy-l-proline
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racemase
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d-amino
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brucella
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sinorhizobium
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abortus
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d-proline
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hypd
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analysis
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semialdehyde
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epimerization
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meliloti
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cis-4-hydroxy-d-proline
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medicine
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molecular biology
- 5.1.1.8
- trans-4-hydroxy-l-proline
- racemase
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d-amino
- brucella
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sinorhizobium
- abortus
- d-proline
- hypd
- analysis
- semialdehyde
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epimerization
- meliloti
- cis-4-hydroxy-d-proline
- medicine
- molecular biology
Reaction
Synonyms
4-hydroxyproline 2-epimerase, 4-hydroxyproline-2-epimerase, AbLhpA, BaHyPRE, Epimerase, hydroxyproline, FaProR, Hydroxyproline 2-epimerase, Hydroxyproline epimerase, HypE, HyPRE, L-Hydroxyproline epimerase, proline racemase/hydroxyproline epimerase, ProR/HypE, PrpA, Smb20268
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General Information
General Information on EC 5.1.1.8 - 4-hydroxyproline epimerase
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evolution
malfunction
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a hypRE mutant grows with cis-4-hydroxy-D-proline but not with trans-4-hydroxy-L-proline, and it exhibits wild-type growth on succinate and proline, mutant complementation with the native smb20268 gene
metabolism
physiological function
additional information
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the reaction mechanism requires two active site cysteines
4-hydroxyproline 2-epimerase is a member of proline racemase family
evolution
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4-hydroxyproline 2-epimerase is a member of proline racemase family
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the enzyme performs the first step of hydroxyproline catabolism, regulation, hyp cluster promoters are regulated by HypR, overview. cis-4-Hydroxy-D-proline is the effector that interacts with HypR and the results suggest a role of positive feedback in the regulation of hyp catabolism, as cis-4-hydroxy-D-proline (or a downstream catabolite) is a stronger inducer than the initial substrate trans-4-hydroxy-L-proline
metabolism
the enzyme is involved in the metabolic pathway of trans-4-hydroxy-L-proline
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the enzyme is absolutely required for growth on trans-4-hydroxy-L-proline
physiological function
the enzyme 4-hydroxyproline 2-epimerase reversibly catalyse the interconversion of trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline. The Brucella proline racemase (PrpA) or hydroxyproline epimerase (BaHyPRE) also exhibit B-cell mitogenic properties thereby causing B-lymphocytes polyclonal activation and increase secretion of interleukin (IL)-10. Importance of PrpA in brucellosis
physiological function
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the enzyme 4-hydroxyproline 2-epimerase reversibly catalyse the interconversion of trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline. The Brucella proline racemase (PrpA) or hydroxyproline epimerase (BaHyPRE) also exhibit B-cell mitogenic properties thereby causing B-lymphocytes polyclonal activation and increase secretion of interleukin (IL)-10. Importance of PrpA in brucellosis
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