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5.1.1.8: 4-hydroxyproline epimerase

This is an abbreviated version!
For detailed information about 4-hydroxyproline epimerase, go to the full flat file.

Word Map on EC 5.1.1.8

Reaction

trans-4-hydroxy-L-proline
=
cis-4-hydroxy-D-proline

Synonyms

4-hydroxyproline 2-epimerase, 4-hydroxyproline-2-epimerase, AbLhpA, BaHyPRE, Epimerase, hydroxyproline, FaProR, Hydroxyproline 2-epimerase, Hydroxyproline epimerase, HypE, HyPRE, L-Hydroxyproline epimerase, proline racemase/hydroxyproline epimerase, ProR/HypE, PrpA, Smb20268

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.1 Acting on amino acids and derivatives
                5.1.1.8 4-hydroxyproline epimerase

Expression

Expression on EC 5.1.1.8 - 4-hydroxyproline epimerase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
live attenuated Salmonella typhimurium (ST) vector constitutively expressing heterologous Brucella abortus S19 PrpA protein (ST-PrpA) is inoculated in BALB/c mice. No aggravation of morbidity is observed upon mice inoculation of ST-PrpA. Immunized mice show significantly quicker anti-Salmonella IgG responses as compared to ST only immunization, and an increase interleukin-4 production evident in in vitro pulsed mice splenocytes, splenocytes proliferative profiles and lymphocyte population evaluation, overview
the enzyme is strongly induced by cis-4-hydroxy-D-proline, moderately by trans-4-hydroxy-L-proline
-