5.1.1.5: lysine racemase
This is an abbreviated version!
For detailed information about lysine racemase, go to the full flat file.
Word Map on EC 5.1.1.5
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5.1.1.5
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d-lysine
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putida
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lyr
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enantiomers
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l-pipecolate
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non-antibiotic
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molecular biology
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biotechnology
- 5.1.1.5
- d-lysine
- putida
- lyr
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enantiomers
- l-pipecolate
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non-antibiotic
- molecular biology
- biotechnology
Reaction
Synonyms
lyr, lysine racemase, Racemase, lysine
ECTree
5.1.1.5 lysine racemaseAdvanced search results
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Substrates Products on EC 5.1.1.5 - lysine racemase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-lysine
D-lysine
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D-lysine is used by the transgenic plants as nitrogen source
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r
L-lysine
D-lysine
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enzyme exhibits higher specific activity toward lysine in the L-lysine to D-lysine direction than in the reverse reaction
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r
additional information
?
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the Oenococcus oeni lysine racemase has a specific activity towards basic amino acids, residues Thr224 and Trp355 are important for enzyme substrate specificity
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?
additional information
?
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the Oenococcus oeni lysine racemase has a specific activity towards basic amino acids, residues Thr224 and Trp355 are important for enzyme substrate specificity
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?
additional information
?
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enzyme residue S394 residue plays a crucial role in determining the preference of Lyr to lysine and arginine. No activity by wild-type and mutant enzyme with alanine, methionine, histidine, tryptophan, leucine, glutamine, asparagine and serine
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?
additional information
?
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enzyme residue S394 residue plays a crucial role in determining the preference of Lyr to lysine and arginine. No activity by wild-type and mutant enzyme with alanine, methionine, histidine, tryptophan, leucine, glutamine, asparagine and serine
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?
additional information
?
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lysine racemase, although functionally inactive for growth purposes, may still have regulatory significance in permitting cross-induction of D-lysine-related enzymes by L-lysine, and vice versa
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?
additional information
?
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L-Lys gives rise to L-pipecolate that is utilized in the biosynthesis of the piperidine alkaloids 1-acetoxy-6-aminooctahydroindolizine and 3,4,5-trihydroxyoctahydro-1-pyridine. D-Lys is converted to D-N6-acetyllysine prior to further catabolism
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?
