5.1.1.5: lysine racemase

This is an abbreviated version!
For detailed information about lysine racemase, go to the full flat file.

Reaction

Synonyms

lyr, lysine racemase, Racemase, lysine

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.1 Acting on amino acids and derivatives

                5.1.1.5 lysine racemase

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Results	in table
11	AA Sequence
4	Application
1	CAS Registry Number
7	Cloned(Commentary)
4	Cofactor
1	Crystallization (Commentary)
1	Expression
4	General Information
4	Inhibitors
16	kcat/KM [mM/s]
28	KM Value [mM]
5	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
14	Organism
6	Pathway
1	PDB ID
6	pH Optimum
1	pH Range
1	pH Stability
25	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
12	Reference
13	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
3	Subunits
11	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
28	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 5.1.1.5 - lysine racemase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-lysine

D-lysine

9 entries

additional information

?

-

4 entries

L-lysine

D-lysine

Oenococcus oeni

Q04HB7

-

727795

-

-

?

L-lysine

D-lysine

Proteus mirabilis

-

-

747470, 748654

-

-

r

L-lysine

D-lysine

Proteus mirabilis

M4GGR9

-

728587

-

-

?

L-lysine

D-lysine

Proteus mirabilis

M4GGR9

-

728711

-

-

r

L-lysine

D-lysine

Proteus mirabilis BCRC10725

-

-

747470

-

-

r

L-lysine

D-lysine

Proteus mirabilis BCRC10725

M4GGR9

-

728587

-

-

?

L-lysine

D-lysine

Proteus mirabilis BCRC10725

M4GGR9

-

728711

-

-

r

L-lysine

D-lysine

uncultured bacterium

C7ACH5

-

706257

D-lysine is used by the transgenic plants as nitrogen source

-

r

L-lysine

D-lysine

uncultured bacterium

C7ACH5

-

701800

enzyme exhibits higher specific activity toward lysine in the L-lysine to D-lysine direction than in the reverse reaction

-

r

additional information

?

-

Oenococcus oeni

Q04HB7

the Oenococcus oeni lysine racemase has a specific activity towards basic amino acids, residues Thr224 and Trp355 are important for enzyme substrate specificity

727795

-

-

?

additional information

?

-

Oenococcus oeni

-

the Oenococcus oeni lysine racemase has a specific activity towards basic amino acids, residues Thr224 and Trp355 are important for enzyme substrate specificity

727795

-

-

?

additional information

?

-

Pseudomonas putida

-

lysine racemase, although functionally inactive for growth purposes, may still have regulatory significance in permitting cross-induction of D-lysine-related enzymes by L-lysine, and vice versa

2133

-

-

?

additional information

?

-

Slafractonia leguminicola

-

L-Lys gives rise to L-pipecolate that is utilized in the biosynthesis of the piperidine alkaloids 1-acetoxy-6-aminooctahydroindolizine and 3,4,5-trihydroxyoctahydro-1-pyridine. D-Lys is converted to D-N6-acetyllysine prior to further catabolism

2132

-

-

?