5.1.1.4: proline racemase

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For detailed information about proline racemase, go to the full flat file.

Word Map on EC 5.1.1.4

5.1.1.4

trypanosoma

cruzi

d-proline

chagas

oversaturated

diaminopimelate

2-epimerase

pyrrole-2-carboxylic

stickland

medicine

abeles

trypanosomosis

stereoinversion

pracs

lumazine

drug development

Reaction

Synonyms

CdPRAC, CdProR, FaProR, HjProR, PA45-A, PA45-B, PRAC, PRAC1, PrdF, proline racemase, proline racemase A, proline racemase B, proline racemase/hydroxyproline epimerase, ProR, ProR/HypE, Racemase, proline, TcPA45, TcPRAC, TcPRACA, TcPRACB, Tgr.146.1080, TryPRAC, TvHYP1, TvPRAC

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.4 proline racemase

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Results	in table
7	Activating Compound
668	AA Sequence
5	Application
1	CAS Registry Number
26	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
3	Expression
32	General Information
6	IC50 Value
51	Inhibitors
15	kcat/KM [mM/s]
10	Ki Value [mM]
24	KM Value [mM]
7	Localization
1	Metals/Ions
15	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
75	Organism
6	Pathway
15	PDB ID
9	pH Optimum
1	pH Range
1	pI Value
7	Protein Variants
13	Purification (Commentary)
12	Reaction
5	Reaction Type
64	Reference
8	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
41	Substrates and Products (Substrate)
15	Subunits
108	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
15	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 5.1.1.4 - proline racemase

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L-Pro

D-Pro

Trypanosoma cruzi

Q4DA80

overexpression of TcPRAC leads to an increase in parasite differentiation into infective forms and its subsequent penetration into host cells. During infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen

662908

L-proline

D-proline

6 entries

additional information

2 entries