5.1.1.21: isoleucine 2-epimerase
This is an abbreviated version!
For detailed information about isoleucine 2-epimerase, go to the full flat file.
Word Map on EC 5.1.1.21
-
5.1.1.21
-
buchneri
-
racemization
-
lactobacillus
-
epimerization
-
5'-phosphate
-
pyridoxal
-
nonpolar
-
d-leucine
-
diaminopimelate
-
two-base
-
l-isoleucine
-
d-valine
- 5.1.1.21
- buchneri
-
racemization
- lactobacillus
-
epimerization
- 5'-phosphate
- pyridoxal
-
nonpolar
- d-leucine
- diaminopimelate
-
two-base
- l-isoleucine
- d-valine
Reaction
Synonyms
amino acid racemase, BCAA racemase, branched-chain amino-acid racemase, D-amino acid racemase, DAAR1, ILEP, isoleucine 2-epimerase, phenazine biosynthesis PhzC/PhzF family protein, PLP-dependent fold-type I isoleucine 2-epimerase, PLP-independent racemase
ECTree
5.1.1.21 isoleucine 2-epimeraseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 5.1.1.21 - isoleucine 2-epimerase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-2-aminobutyric acid
(S)-2-aminobutyric acid
activity is 42% compared to D-allo-isoleucine
-
-
r
(S)-2-aminobutyric acid
(R)-2-aminobutyric acid
activity is 32% compared to L-isoleucine
-
-
r
D-leucine
L-leucine
activity is 30% compared to D-allo-isoleucine
-
-
?
D-methionine
L-methionine
activity is 20% compared to D-allo-isoleucine
-
-
?
D-norleucine
L-norleucine
activity is 59% compared to D-allo-isoleucine
-
-
r
D-phenylalanine
L-phenylalanine
activity is 25% compared to D-allo-isoleucine
-
-
?
D-valine
L-Val
activity is 52% compared to D-allo-isoleucine
-
-
r
L-phenylalanine
D-phenylalanine
activity is 24% compared to L-isoleucine
-
-
?
L-valine
D-Val
activity is 48% compared to L-isoleucine
-
-
r
D-norvaline
L-norvaline
activity is 83% compared to D-allo-isoleucine
-
-
r
D-norvaline
L-norvaline
activity is 83% compared to D-allo-isoleucine
-
-
r
L-leucine
D-leucine
activity is 30% compared to L-isoleucine
-
-
?
L-Methionine
D-Methionine
activity is 19% compared to L-isoleucine
-
-
?
L-Methionine
D-Methionine
activity is 19% compared to L-isoleucine
-
-
?
L-Norleucine
D-Norleucine
activity is 50% compared to L-isoleucine
-
-
r
L-Norleucine
D-Norleucine
activity is 50% compared to L-isoleucine
-
-
r
L-Norvaline
D-Norvaline
activity is 56% compared to L-isoleucine
-
-
r
L-Norvaline
D-Norvaline
activity is 56% compared to L-isoleucine
-
-
r
additional information
?
-
the enzyme does not require pyridoxal 5'-phosphate for its activity. Compared with Ile, DAAR1 shows 1 and 5% relative activity toward Leu and Val, respectively. DAAR1 shows no activity toward N-acetyl-L-Ile, a commercially available surrogate for N-malonyl-L-Ile, suggesting that DAAR1 does not use a N-derivatized substrate
-
-
?
additional information
?
-
-
the enzyme does not require pyridoxal 5'-phosphate for its activity. Compared with Ile, DAAR1 shows 1 and 5% relative activity toward Leu and Val, respectively. DAAR1 shows no activity toward N-acetyl-L-Ile, a commercially available surrogate for N-malonyl-L-Ile, suggesting that DAAR1 does not use a N-derivatized substrate
-
-
?
additional information
?
-
the enzyme specifically catalyzes racemization of nonpolar amino acids at the C-2 position. No activity toward the L- and D-forms of Asp, Glu, Lys, Arg, His, Orn, Thr, Asn, Gln, Trp, and tert-Leu
-
-
?
additional information
?
-
-
the enzyme specifically catalyzes racemization of nonpolar amino acids at the C-2 position. No activity toward the L- and D-forms of Asp, Glu, Lys, Arg, His, Orn, Thr, Asn, Gln, Trp, and tert-Leu
-
-
?
additional information
?
-
the enzyme catalyzes the pyridoxal 5'-phosphate (PLP)-dependent racemization and epimerization of a broad spectrum of nonpolar amino acids from L- to D-form and vice versa, in particular isoleucine
-
-
?
additional information
?
-
-
the enzyme catalyzes the pyridoxal 5'-phosphate (PLP)-dependent racemization and epimerization of a broad spectrum of nonpolar amino acids from L- to D-form and vice versa, in particular isoleucine
-
-
?
additional information
?
-
the enzyme specifically catalyzes racemization of nonpolar amino acids at the C-2 position. No activity toward the L- and D-forms of Asp, Glu, Lys, Arg, His, Orn, Thr, Asn, Gln, Trp, and tert-Leu
-
-
?
additional information
?
-
the enzyme catalyzes the pyridoxal 5'-phosphate (PLP)-dependent racemization and epimerization of a broad spectrum of nonpolar amino acids from L- to D-form and vice versa, in particular isoleucine
-
-
?
