5.1.1.21: isoleucine 2-epimerase
This is an abbreviated version!
For detailed information about isoleucine 2-epimerase, go to the full flat file.
Word Map on EC 5.1.1.21
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5.1.1.21
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buchneri
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racemization
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lactobacillus
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epimerization
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5'-phosphate
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pyridoxal
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nonpolar
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d-leucine
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diaminopimelate
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two-base
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l-isoleucine
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d-valine
- 5.1.1.21
- buchneri
-
racemization
- lactobacillus
-
epimerization
- 5'-phosphate
- pyridoxal
-
nonpolar
- d-leucine
- diaminopimelate
-
two-base
- l-isoleucine
- d-valine
Reaction
Synonyms
amino acid racemase, BCAA racemase, branched-chain amino-acid racemase, D-amino acid racemase, DAAR1, ILEP, isoleucine 2-epimerase, phenazine biosynthesis PhzC/PhzF family protein, PLP-dependent fold-type I isoleucine 2-epimerase, PLP-independent racemase
ECTree
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Reaction
Reaction on EC 5.1.1.21 - isoleucine 2-epimerase
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L-isoleucine = D-allo-isoleucine
L-isoleucine epimerization proceeds through abstraction of the alpha-hydrogen of the substrate by Lys280, while Asp222 serves as the catalytic residue adding an alpha-hydrogen to the quinonoid intermediate to form D-allo-isoleucine, structure-function relationship
L-isoleucine = D-allo-isoleucine
the racemization reaction by the fold-type I racemases may generally occur thanks to a revised two-base mechanism. Conformational changes provoked by pyridoxal 5'-phosphate binding suggesting an induced fit of the active site entrance door necessary to accommodate pyridoxal 5'-phosphate and substrate molecules
L-isoleucine = D-allo-isoleucine
the racemization reaction by the fold-type I racemases may generally occur thanks to a revised two-base mechanism. Conformational changes provoked by pyridoxal 5'-phosphate binding suggesting an induced fit of the active site entrance door necessary to accommodate pyridoxal 5'-phosphate and substrate molecules
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