5.1.1.18: serine racemase

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For detailed information about serine racemase, go to the full flat file.

Word Map on EC 5.1.1.18

5.1.1.18

d-serine

n-methyl-d-aspartate

co-agonist

nmdars

astrocyte

d-amino

schizophrenia

neurotransmission

pyridoxal

hypofunction

d-aspartate

glutamatergic

5'-phosphate-dependent

nmda-type

d-ser

plp-dependent

nmdar-mediated

pharmacology

medicine

alanine-serine-cysteine

drug development

glycine-binding

n-methyl-d

vante

brain-enriched

gliotransmitter

nmdar-dependent

Reaction

Synonyms

hSR, More, RiSR, RLO149_c015450, Ser racemase, SerR, SRace, SRR, T01H8.2, Zm-SR, ZmSR

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.18 serine racemase

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Results	in table
58	Activating Compound
118	AA Sequence
10	Application
1	CAS Registry Number
38	Cloned(Commentary)
49	Cofactor
5	Crystallization (Commentary)
103	Disease/ Diagnostics
3	Expression
67	General Information
2	General Stability
3	IC50 Value
158	Inhibitors
47	kcat/KM [mM/s]
25	Ki Value [mM]
96	KM Value [mM]
14	Localization
59	Metals/Ions
36	Molecular Weight [Da]
84	Natural Substrates/ Products (Substrates)
448	Organism
7	Pathway
42	PDB ID
31	pH Optimum
2	pH Range
1	pH Stability
9	Posttranslational Modification
62	Protein Variants
26	Purification (Commentary)
14	Reaction
4	Reaction Type
108	Reference
188	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
194	Substrates and Products (Substrate)
37	Subunits
37	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
3	Temperature Stability [°C]
66	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.1.1.18 - serine racemase

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serine racemase

A pyridoxal-phosphate protein that is highly selective for L-serine as substrate. D-Serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors [1,2]. The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations [4].