5.1.1.18: serine racemase
This is an abbreviated version!
For detailed information about serine racemase, go to the full flat file.
Word Map on EC 5.1.1.18
-
5.1.1.18
-
d-serine
-
n-methyl-d-aspartate
-
co-agonist
-
nmdars
-
astrocyte
-
d-amino
-
schizophrenia
-
neurotransmission
-
pyridoxal
-
hypofunction
-
d-aspartate
-
glutamatergic
-
5'-phosphate-dependent
-
nmda-type
-
d-ser
-
plp-dependent
-
nmdar-mediated
-
pharmacology
-
medicine
-
alanine-serine-cysteine
-
drug development
-
glycine-binding
-
n-methyl-d
-
vante
-
brain-enriched
-
gliotransmitter
-
nmdar-dependent
- 5.1.1.18
- d-serine
- n-methyl-d-aspartate
-
co-agonist
-
nmdars
- astrocyte
-
d-amino
-
schizophrenia
-
neurotransmission
- pyridoxal
-
hypofunction
- d-aspartate
-
glutamatergic
-
5'-phosphate-dependent
-
nmda-type
- d-ser
-
plp-dependent
-
nmdar-mediated
- pharmacology
- medicine
-
alanine-serine-cysteine
- drug development
-
glycine-binding
-
n-methyl-d
-
vante
-
brain-enriched
-
gliotransmitter
-
nmdar-dependent
Reaction
Synonyms
hSR, More, RiSR, RLO149_c015450, Ser racemase, SerR, SRace, SRR, T01H8.2, Zm-SR, ZmSR
ECTree
5.1.1.18 serine racemaseAdvanced search results
results (
results (Reference
top
Reference on EC 5.1.1.18 - serine racemase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, L.Z.; Zhu, X.Z.
Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development
Acta Pharmacol. Sin.
24
965-974
2003
Mus musculus
Svensson, M.L.; Gatenbeck, S.
The presence of two serine racemases in Streptomyces garyphalus, a D-cycloserine producer
Arch. Microbiol.
129
213-215
1981
Streptomyces garyphalus
-
Strisovsky, K.; Jiraskova, J.; Mikulova, A.; Rulisek, L.; Konvalinka, J.
Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity
Biochemistry
44
13091-13100
2005
Mus musculus (Q9QZX7), Mus musculus
Wu, S.; Barger, S.W.; Sims, T.J.
Schwann cell and epineural fibroblast expression of serine racemase
Brain Res.
1020
161-166
2004
Rattus norvegicus
Xia, M.; Liu, Y.; Figueroa, D.J.; Chiu, C.S.; Wei, N.; Lawlor, A.M.; Lu, P.; Sur, C.; Koblan, K.S.; Connolly, T.M.
Characterization and localization of a human serine racemase
Brain Res. Mol. Brain Res.
125
96-104
2004
Homo sapiens (Q9GZT4), Homo sapiens
Dunlop, D.S.; Neidle, A.
Regulation of serine racemase activity by amino acids
Brain Res. Mol. Brain Res.
133
208-214
2005
Mus musculus
Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.
Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate
FEBS Lett.
535
44-48
2003
Mus musculus (Q9QZX7), Mus musculus
De Miranda, J.; Santoro, A.; Engelender, S.; Wolosker, H.
Human serine racemase: molecular cloning, genomic organization and functional analysis
Gene
256
183-188
2000
Homo sapiens (Q9GZT4), Homo sapiens
Cook, S.P.; Galve-Roperh, I.; Martinez del Pozo, A.; Rodriguez-Crespo, I.
Direct calcium binding results in activation of brain serine racemase
J. Biol. Chem.
277
27782-27792
2002
Mus musculus
Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
J. Biol. Chem.
280
1754-1763
2005
Mus musculus
Wu, S.Z.; Bodles, A.M.; Porter, M.M.; Griffin, W.S.; Basile, A.S.; Barger, S.W.
Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide
J. Neuroinflammation
1
2
2004
Rattus norvegicus
Arias, C.A.; Martin-Martinez, M.; Blundell, T.L.; Arthur, M.; Courvalin, P.; Reynolds, P.E.
Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174
Mol. Microbiol.
31
1653-1664
1999
Enterococcus gallinarum, Enterococcus gallinarum BM4174
Neidle, A.; Dunlop, D.S.
Allosteric regulation of mouse brain serine racemase
Neurochem. Res.
27
1719-1724
2002
Mus musculus
Shoji, K.; Mariotto, S.; Ciampa, A.R.; Suzuki, H.
Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells
Neurosci. Lett.
392
75-78
2006
Homo sapiens
Dememes, D.; Mothet, J.P.; Nicolas, M.T.
Cellular distribution of d-serine, serine racemase and d-amino acid oxidase in the rat vestibular sensory epithelia
Neuroscience
137
991-997
2006
Rattus norvegicus
Stevens, E.R.; Esguerra, M.; Kim, P.M.; Newman, E.A.; Snyder, S.H.; Zahs, K.R.; Miller, R.F.
D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors
Proc. Natl. Acad. Sci. USA
100
6789-6794
2003
Ambystoma tigrinum, Mus musculus, Rattus norvegicus
Kim, P.M.; Aizawa, H.; Kim, P.S.; Huang, A.S.; Wickramasinghe, S.R.; Kashani, A.H.; Barrow, R.K.; Huganir, R.L.; Ghosh, A.; Snyder, S.H.
Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration
Proc. Natl. Acad. Sci. USA
102
2105-2110
2005
Mus musculus
Wolosker, H.; Blackshaw, S.; Snyder, S.H.
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
Proc. Natl. Acad. Sci. USA
96
13409-13414
1999
Mus musculus (Q9QZX7)
Wolosker, H.; Sheth, K.N.; Takahashi, M.; Mothet, J.P.; Brady, R.O., Jr.; Ferris, C.D.; Snyder, S.H.
Purification of serine racemase: biosynthesis of the neuromodulator D-serine
Proc. Natl. Acad. Sci. USA
96
721-725
1999
Rattus norvegicus
De Miranda, J.; Panizzutti, R.; Foltyn, V.N.; Wolosker, H.
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine
Proc. Natl. Acad. Sci. USA
99
14542-14547
2002
Mus musculus
Nagayoshi, C.; Ishibashi, M.; Kita, Y.; Matsuoka, M.; Nishimoto, I.; Tokunaga, M.
Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag
Protein Pept. Lett.
12
487-490
2005
Homo sapiens
Wu, S.; Basile, A.S.; Barger, S.W.
Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP)
Curr. Alzheimer Res.
4
243-251
2007
Rattus norvegicus, Homo sapiens (Q9GZT4)
Verrall, L.; Walker, M.; Rawlings, N.; Benzel, I.; Kew, J.N.; Harrison, P.J.; Burnet, P.W.
D-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia
Eur. J. Neurosci.
26
1657-1669
2007
Homo sapiens
Takeyama, K.; Yoshikawa, M.; Oka, T.; Kawaguchi, M.; Suzuki, T.; Hashimoto, A.
Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain
Eur. J. Pharmacol.
540
82-86
2006
Rattus norvegicus
Hashimoto, A.; Yoshikawa, M.; Andoh, H.; Yano, H.; Matsumoto, H.; Kawaguchi, M.; Oka, T.; Kobayashi, H.
Effects of MK-801 on the expression of serine racemase and D-amino acid oxidase mRNAs and on the D-serine levels in rat brain
Eur. J. Pharmacol.
555
17-22
2007
Rattus norvegicus
Dun, Y.; Mysona, B.; Itagaki, S.; Martin-Studdard, A.; Ganapathy, V.; Smith, S.B.
Functional and molecular analysis of D-serine transport in retinal Mueller cells
Exp. Eye Res.
84
191-199
2007
Rattus norvegicus (Q76EQ0)
Baumgart, F.; Mancheno, J.M.; Rodriguez-Crespo, I.
Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP
FEBS J.
274
4561-4571
2007
Mus musculus
Ohnishi, M.; Saito, M.; Wakabayashi, S.; Ishizuka, M.; Nishimura, K.; Nagata, Y.; Kasai, S.
Purification and characterization of serine racemase from a hyperthermophylum Pyrobaculum islandicum
J. Bacteriol.
190
1359-1365
2007
Pyrobaculum islandicum, Pyrobaculum islandicum (Q2V0H1)
Dun, Y.; Duplantier, J.; Roon, P.; Martin, P.M.; Ganapathy, V.; Smith, S.B.
Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina
J. Neurochem.
104
970-978
2007
Mus musculus, Mus musculus C57/BL6J
Steffek, A.E.; Haroutunian, V.; Meador-Woodruff, J.H.
Serine racemase protein expression in cortex and hippocampus in schizophrenia
NeuroReport
17
1181-1185
2006
Homo sapiens
Fujitani, Y.; Nakajima, N.; Ishihara, K.; Oikawa, T.; Ito, K.; Sugimoto, M.
Molecular and biochemical characterization of a serine racemase from Arabidopsis thaliana
Phytochemistry
67
668-674
2006
Arabidopsis thaliana (Q2PGG3), Arabidopsis thaliana
Fujitani, Y.; Horiuchi, T.; Ito, K.; Sugimoto, M.
Serine racemases from barley, Hordeum vulgare L., and other plant species represent a distinct eukaryotic group: gene cloning and recombinant protein characterization
Phytochemistry
68
1530-1536
2007
Hordeum vulgare (A5HUN0), Hordeum vulgare
Mustafa, A.K.; Kumar, M.; Selvakumar, B.; Ho, G.P.; Ehmsen, J.T.; Barrow, R.K.; Amzel, L.M.; Snyder, S.H.
Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation
Proc. Natl. Acad. Sci. USA
104
2950-2955
2007
Mus musculus (Q9QZX7)
Yoshikawa, M.; Shinomiya, T.; Takayasu, N.; Tsukamoto, H.; Kawaguchi, M.; Kobayashi, H.; Oka, T.; Hashimoto, A.
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase
J. Pharmacol. Sci.
107
270-276
2008
Rattus norvegicus (Q76EQ0)
Sugimoto, M.; Sakamoto, W.; Fujitani, Y.
Localization and expression of serine racemase in Arabidopsis thaliana
Amino Acids
36
587-590
2009
Arabidopsis thaliana
Takayasu, N.; Yoshikawa, M.; Watanabe, M.; Tsukamoto, H.; Suzuki, T.; Kobayashi, H.; Noda, S.
The serine racemase mRNA is expressed in both neurons and glial cells of the rat retina
Arch. Histol. Cytol.
71
123-129
2008
Rattus norvegicus (Q76EQ0)
Hikida, T.; Mustafa, A.K.; Maeda, K.; Fujii, K.; Barrow, R.K.; Saleh, M.; Huganir, R.L.; Snyder, S.H.; Hashimoto, K.; Sawa, A.
Modulation of D-serine levels in brains of mice lacking PICK1
Biol. Psychiatry
63
997-1000
2008
Mus musculus
Takarada, T.; Hinoi, E.; Takahata, Y.; Yoneda, Y.
Serine racemase suppresses chondrogenic differentiation in cartilage in a Sox9-dependent manner
J. Cell. Physiol.
215
320-328
2008
Rattus norvegicus
Miya, K.; Inoue, R.; Takata, Y.; Abe, M.; Natsume, R.; Sakimura, K.; Hongou, K.; Miyawaki, T.; Mori, H.
Serine racemase is predominantly localized in neurons in mouse brain
J. Comp. Neurol.
510
641-654
2008
Mus musculus
Inoue, R.; Hashimoto, K.; Harai, T.; Mori, H.
NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice
J. Neurosci.
28
14486-14491
2008
Mus musculus
Basu, A.C.; Tsai, G.E.; Ma, C.L.; Ehmsen, J.T.; Mustafa, A.K.; Han, L.; Jiang, Z.I.; Benneyworth, M.A.; Froimowitz, M.P.; Lange, N.; Snyder, S.H.; Bergeron, R.; Coyle, J.T.
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
Mol. Psychiatry
14
719-727
2008
Mus musculus
Hoffman, H.E.; Jiraskova, J.; Ingr, M.; Zvelebil, M.; Konvalinka, J.
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog
Protein Expr. Purif.
63
62-67
2009
Homo sapiens, Mus musculus
Hoffman, H.; Jiraskova¡, J.; Zvelebil, M.; Konvalinka, J.
Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity
Collect. Czech. Chem. Commun.
75
59-79
2010
Homo sapiens
-
Labrie, V.; Fukumura, R.; Rastogi, A.; Fick, L.J.; Wang, W.; Boutros, P.C.; Kennedy, J.L.; Semeralul, M.O.; Lee, F.H.; Baker, G.B.; Belsham, D.D.; Barger, S.W.; Gondo, Y.; Wong, A.H.; Roder, J.C.
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model
Hum. Mol. Genet.
18
3227-3243
2009
Homo sapiens, Mus musculus, Mus musculus C57BL/6JJcl
Yamauchi, T.; Goto, M.; Wu, H.Y.; Uo, T.; Yoshimura, T.; Mihara, H.; Kurihara, T.; Miyahara, I.; Hirotsu, K.; Esaki, N.
Serine racemase with catalytically active lysinoalanyl residue
J. Biochem.
145
421-424
2009
Schizosaccharomyces pombe (O59791), Schizosaccharomyces pombe
Goto, M.; Yamauchi, T.; Kamiya, N.; Miyahara, I.; Yoshimura, T.; Mihara, H.; Kurihara, T.; Hirotsu, K.; Esaki, N.
Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe
J. Biol. Chem.
284
25944-25952
2009
Schizosaccharomyces pombe (O59791), Schizosaccharomyces pombe
Smith, M.A.; Mack, V.; Ebneth, A.; Moraes, I.; Felicetti, B.; Wood, M.; Schonfeld, D.; Mather, O.; Cesura, A.; Barker, J.
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding
J. Biol. Chem.
285
12873-12881
2010
Rattus norvegicus, Homo sapiens (Q9GZT4), Homo sapiens
Hoffman, H.E.; Jiraskova, J.; Cigler, P.; Sanda, M.; Schraml, J.; Konvalinka, J.
Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor
J. Med. Chem.
52
6032-6041
2009
Mus musculus
Sikka, P.; Walker, R.; Cockayne, R.; Wood, M.J.; Harrison, P.J.; Burnet, P.W.
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO)
J. Neurosci. Res.
88
1829-1840
2010
Rattus norvegicus (Q76EQ0)
Mustafa, A.K.; Ahmad, A.S.; Zeynalov, E.; Gazi, S.K.; Sikka, G.; Ehmsen, J.T.; Barrow, R.K.; Coyle, J.T.; Snyder, S.H.; Dore, S.
Serine racemase deletion protects against cerebral ischemia and excitotoxicity
J. Neurosci.
30
1413-1416
2010
Mus musculus
Gogami, Y.; Ito, K.; Kamitani, Y.; Matsushima, Y.; Oikawa, T.
Occurrence of D-serine in rice and characterization of rice serine racemase
Phytochemistry
70
380-387
2009
Oryza sativa (Q7XSN8), Oryza sativa
Mustafa, A.K.; van Rossum, D.B.; Patterson, R.L.; Maag, D.; Ehmsen, J.T.; Gazi, S.K.; Chakraborty, A.; Barrow, R.K.; Amzel, L.M.; Snyder, S.H.
Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition
Proc. Natl. Acad. Sci. USA
106
2921-2926
2009
Mus musculus
Balan, L.; Foltyn, V.N.; Zehl, M.; Dumin, E.; Dikopoltsev, E.; Knoh, D.; Ohno, Y.; Kihara, A.; Jensen, O.N.; Radzishevsky, I.S.; Wolosker, H.
Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane
Proc. Natl. Acad. Sci. USA
106
7589-7594
2009
Rattus norvegicus
Nagayoshi, C.; Ishibashi, M.; Tokunaga, M.
Purification and characterization of human brain serine racemase expressed in moderately halophilic bacteria
Protein Pept. Lett.
16
201-206
2009
Homo sapiens
Wolosker, H.
Serine racemase and the serine shuttle between neurons and astrocytes
Biochim. Biophys. Acta
1814
1558-1566
2011
Mus musculus
Gogami, Y.; Kobayashi, A.; Ikeuchi, T.; Oikawa, T.
Site-directed mutagenesis of rice serine racemase: evidence that Glu219 and Asp225 mediate the effects of Mg2+ on the activity
Chem. Biodivers.
7
1579-1590
2010
Oryza sativa
Foltyn, V.N.; Zehl, M.; Dikopoltsev, E.; Jensen, O.N.; Wolosker, H.
Phosphorylation of mouse serine racemase regulates D-serine synthesis
FEBS Lett.
584
2937-2941
2010
Mus musculus
Ding, X.; Ma, N.; Nagahama, M.; Yamada, K.; Semba, R.
Localization of D-serine and serine racemase in neurons and neuroglias in mouse brain
Neurol. Sci.
32
263-267
2011
Mus musculus
Ito, T.; Murase, H.; Maekawa, M.; Goto, M.; Hayashi, S.; Saito, H.; Maki, M.; Hemmi, H.; Yoshimura, T.
Metal ion dependency of serine racemase from Dictyostelium discoideum
Amino Acids
43
1567-1576
2012
Dictyostelium discoideum
Wolosker, H.; Mori, H.
Serine racemase: an unconventional enzyme for an unconventional transmitter
Amino Acids
43
1895-1904
2012
Mus musculus, Mus musculus C57BL/6
Ito, T.; Maekawa, M.; Hayashi, S.; Goto, M.; Hemmi, H.; Yoshimura, T.
Catalytic mechanism of serine racemase from Dictyostelium discoideum
Amino Acids
44
1073-1084
2013
Dictyostelium discoideum
Harty, M.; Nagar, M.; Atkinson, L.; Legay, C.M.; Derksen, D.J.; Bearne, S.L.
Inhibition of serine and proline racemases by substrate-product analogues
Bioorg. Med. Chem. Lett.
24
390-393
2014
Schizosaccharomyces pombe
Wang, W.; Barger, S.W.
Roles of quaternary structure and cysteine residues in the activity of human serine racemase
BMC Biochem.
12
63
2011
Homo sapiens
Balu, D.T.; Takagi, S.; Puhl, M.D.; Benneyworth, M.A.; Coyle, J.T.
D-Serine and serine racemase are localized to neurons in the adult mouse and human forebrain
Cell. Mol. Neurobiol.
34
419-435
2014
Homo sapiens, Mus musculus
Marchetti, M.; Bruno, S.; Campanini, B.; Peracchi, A.; Mai, N.; Mozzarelli, A.
ATP binding to human serine racemase is cooperative and modulated by glycine
FEBS J.
280
5853-5863
2013
Homo sapiens
Campanini, B.; Spyrakis, F.; Peracchi, A.; Mozzarelli, A.
Serine racemase: a key player in neuron activity and in neuropathologies
Front. Biosci.
18
1112-1128
2013
Homo sapiens
Ohide, H.; Miyoshi, Y.; Maruyama, R.; Hamase, K.; Konno, R.
D-Amino acid metabolism in mammals: biosynthesis, degradation and analytical aspects of the metabolic study
J. Chromatogr. B
879
3162-3168
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Inoue, R.; Yoshihisa, Y.; Tojo, Y.; Okamura, C.; Yoshida, Y.; Kishimoto, J.; Luan, X.; Watanabe, M.; Mizuguchi, M.; Nabeshima, Y.; Hamase, K.; Matsunaga, K.; Shimizu, T.; Mori, H.
Localization of serine racemase and its role in the skin
J. Invest. Dermatol.
134
1618-1626
2014
Mus musculus, Mus musculus C57BL/6
Horio, M.; Kohno, M.; Fujita, Y.; Ishima, T.; Inoue, R.; Mori, H.; Hashimoto, K.
Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine
PLoS ONE
7
e35494
2012
Mus musculus
Wang, C.Y.; Ku, S.C.; Lee, C.C.; Wang, A.H.
Modulating the function of human serine racemase and human serine dehydratase by protein engineering
Protein Eng. Des. Sel.
25
741-749
2012
Homo sapiens (Q9GZT4), Homo sapiens
Zou, L.; Song, Y.; Wang, C.; Sun, J.; Wang, L.; Cheng, B.; Fan, J.
Crystal structure of maize serine racemase with pyridoxal 5-phosphate
Acta Crystallogr. Sect. F
72
165-171
2016
Zea mays (F5CAQ9), Zea mays
Uda, K.; Abe, K.; Dehara, Y.; Mizobata, K.; Edashige, Y.; Nishimura, R.; Radkov, A.D.; Moe, L.A.
Triple serine loop region regulates the aspartate racemase activity of the serine/aspartate racemase family
Amino Acids
49
1743-1754
2017
Acropora millepora, Penaeus monodon (A0A0U4MRI4), Crassostrea gigas (A0A0U5AKI6), Mus musculus (Q9QZX7), Mus musculus
Bruno, S.; Marchesani, F.; Dellafiora, L.; Margiotta, M.; Faggiano, S.; Campanini, B.; Mozzarelli, A.
Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives
Biochem. J.
473
3505-3516
2016
Homo sapiens (Q9GZT4), Homo sapiens
Nitoker, N.; Major, D.T.
Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations
Biochemistry
54
516-527
2015
Rattus norvegicus (Q76EQ0), Homo sapiens (Q9GZT4), Homo sapiens
Talukdar, G.; Inoue, R.; Yoshida, T.; Ishimoto, T.; Yaku, K.; Nakagawa, T.; Mori, H.
Novel role of serine racemase in anti-apoptosis and metabolism
Biochim. Biophys. Acta
1861
3378-3387
2017
Mus musculus (Q9QZX7)
Marchesani, F.; Bruno, S.; Paredi, G.; Raboni, S.; Campanini, B.; Mozzarelli, A.
Human serine racemase is nitrosylated at multiple sites
Biochim. Biophys. Acta
1866
813-821
2018
Homo sapiens (Q9GZT4), Homo sapiens
Mori, H.; Wada, R.; Li, J.; Ishimoto, T.; Mizuguchi, M.; Obita, T.; Gouda, H.; Hirono, S.; Toyooka, N.
In silico and pharmacological screenings identify novel serine racemase inhibitors
Bioorg. Med. Chem. Lett.
24
3732-3735
2014
Homo sapiens (Q9GZT4)
Takahara, S.; Nakagawa, K.; Uchiyama, T.; Yoshida, T.; Matsumoto, K.; Kawasumi, Y.; Mizuguchi, M.; Obita, T.; Watanabe, Y.; Hayakawa, D.; Gouda, H.; Mori, H.; Toyooka, N.
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase
Bioorg. Med. Chem. Lett.
28
441-445
2017
Homo sapiens (Q9GZT4), Homo sapiens
Vorlova, B.; Nachtigallova, D.; Jiraskova-Vanickova, J.; Ajani, H.; Jansa, P.; Rezac, J.; Fanfrlik, J.; Otyepka, M.; Hobza, P.; Konvalinka, J.; Lepsik, M.
Malonate-based inhibitors of mammalian serine racemase kinetic characterization and structure-based computational study
Eur. J. Med. Chem.
89
189-197
2015
Homo sapiens (Q9GZT4), Homo sapiens
Canu, N.; Ciotti, M.T.; Pollegioni, L.
Serine racemase a key player in apoptosis and necrosis
Front. Synaptic Neurosci.
6
9
2014
Homo sapiens (Q9GZT4), Mus musculus (Q9QZX7)
Katane, M.; Saitoh, Y.; Uchiyama, K.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Uda, K.; Homma, H.
Characterization of a homologue of mammalian serine racemase from Caenorhabditis elegans the enzyme is not critical for the metabolism of serine invivo
Genes Cells
21
966-977
2016
Caenorhabditis elegans (Q93968), Caenorhabditis elegans, Homo sapiens (Q9GZT4), Homo sapiens, Caenorhabditis elegans N2 (Q93968)
Ito, T.; Hayashida, M.; Kobayashi, S.; Muto, N.; Hayashi, A.; Yoshimura, T.; Mori, H.
Serine racemase is involved in D-aspartate biosynthesis
J. Biochem.
160
345-353
2016
Rattus norvegicus (Q76EQ0), Mus musculus (Q9QZX7)
Shrestha, R.; Lockless, S.W.; Sorg, J.A.
A Clostridium difficile alanine racemase affects spore germination and accommodates serine as a substrate
J. Biol. Chem.
292
10735-10742
2017
Clostridioides difficile, Clostridioides difficile UK1
Kubota, T.; Shimamura, S.; Kobayashi, T.; Nunoura, T.; Deguchi, S.
Distribution of eukaryotic serine racemases in the bacterial domain and characterization of a representative protein in Roseobacter litoralis Och 149
Microbiology
162
53-61
2016
Roseobacter litoralis (F7ZG00), Roseobacter litoralis ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149 (F7ZG00)
html completed
