5.1.1.18: serine racemase
This is an abbreviated version!
For detailed information about serine racemase, go to the full flat file.
Word Map on EC 5.1.1.18
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5.1.1.18
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d-serine
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n-methyl-d-aspartate
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co-agonist
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nmdars
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astrocyte
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d-amino
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schizophrenia
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neurotransmission
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pyridoxal
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hypofunction
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d-aspartate
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glutamatergic
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5'-phosphate-dependent
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nmda-type
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d-ser
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plp-dependent
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nmdar-mediated
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pharmacology
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medicine
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alanine-serine-cysteine
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drug development
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glycine-binding
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n-methyl-d
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vante
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brain-enriched
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gliotransmitter
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nmdar-dependent
- 5.1.1.18
- d-serine
- n-methyl-d-aspartate
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co-agonist
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nmdars
- astrocyte
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d-amino
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schizophrenia
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neurotransmission
- pyridoxal
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hypofunction
- d-aspartate
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glutamatergic
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5'-phosphate-dependent
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nmda-type
- d-ser
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plp-dependent
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nmdar-mediated
- pharmacology
- medicine
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alanine-serine-cysteine
- drug development
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glycine-binding
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n-methyl-d
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vante
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brain-enriched
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gliotransmitter
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nmdar-dependent
Reaction
Synonyms
hSR, More, RiSR, RLO149_c015450, Ser racemase, SerR, SRace, SRR, T01H8.2, Zm-SR, ZmSR
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Natural Substrates Products
Natural Substrates Products on EC 5.1.1.18 - serine racemase
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REACTION DIAGRAM
L-serine
D-serine
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D-serine is an important modulator of the N-methyl-D-aspartate receptor function
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L-serine
D-serine
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D-serine is an N-methyl-d-aspartate receptor co-agonist, synthesized by serine racemase and degraded by d-amino acid oxidase
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L-serine
D-serine
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the astrocytic enzyme synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, and is involved in development of schizophrenia and glutamatergic dysfunction, astrocytes may play a direct role in N-methyl-D-aspartate receptor dysfunction in schizophrenia, overview
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L-serine
D-serine
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D-serine is an important modulator of the N-methyl-D-aspartate receptor function
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L-serine
D-serine
D-serine is a coagonist with glutamate at NMDA receptors, postsynaptic stimulation of nitric-oxide formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors, enzyme regulation, mechanism, overview
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L-serine
D-serine
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developmental regulation of enzyme expression in neuronal ganglion cells of the retina, overview, D-serine is the endogenous ligand for the glycine modulatory binding site of the NMDA receptor
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L-serine
D-serine
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D-serine is stored primarily within astrocytes ensheathing neuronal synapses containing NMDA receptors, model of D-serine signalling in the brain, overview
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L-serine
D-serine
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developmental regulation of enzyme expression in neuronal ganglion cells of the retina, overview, D-serine is the endogenous ligand for the glycine modulatory binding site of the NMDA receptor
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L-serine
D-serine
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D-serine is an important modulator of the N-methyl-D-aspartate receptor function
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L-serine
D-serine
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D-serine is an endogenous N-methyl-D-aspartate, NMDA, receptor coagonist
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L-serine
D-serine
D-serine, an endogenous co-agonist of N-methyl-D-aspartate receptors in vertebrate retina, modulates glutamate sensitivity of retinal neurons, overview
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L-serine
D-serine
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mechanisms regulating D-serine production by the enzyme serine racemase via translocation from cytosol to membranes, overview
D-serine is a physiological coagonist of N-methyl D-aspartate receptors, NMDARs, that plays a major role in several NMDAR-dependent events
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L-serine
D-serine
Roseobacter litoralis ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149
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r
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enzyme product may serve as a ligand for setting the sensitivity of N-methyl-D-aspartate receptors under physiological conditions
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additional information
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the enzyme does not appear to metabolize D- and L-Ser in vivo
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additional information
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the enzyme does not appear to metabolize D- and L-Ser in vivo
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additional information
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the enzyme does not appear to metabolize D- and L-Ser in vivo
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additional information
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serine racemase is the pyridoxal 5'-phosphate-dependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in mammalian brain
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additional information
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the enzyme binds to the glutamate receptor interacting protein, to protein interacting with C kinase 1, and Golgi-localized protein Golga 3
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additional information
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enzyme modulates physiologic regulation of cerebellar granule cell migration
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additional information
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enzyme product may serve as a ligand for setting the sensitivity of N-methyl-D-aspartate receptors under physiological conditions
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additional information
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serine racemase is the major enzyme for D-serine production in the brain, D-serine is the predominant endogenous coagonist of the NMDA receptor in the forebrain, and D-serine may be involved in controlling the extent of NMDA receptor-mediated neurotoxic insults observed in disorders including Alzheimers disease.
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additional information
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the enzyme binds to the glutamate receptor interacting protein, to protein interacting with C kinase 1, and Golgi-localized protein Golga 3. The carboxy terminus of both the mouse and human enzyme contains an amino acid domain that binds to PSD-95/DlgA/zo-1 (PDZ)-containing proteins, such as GRIP and PICK1, which subsequently activates the racemase. The PDZ domain is an important protein-protein interaction motif
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additional information
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enzyme SRR recognizes L-Asp as an in vivo substrate in addition to L- and D-Ser
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additional information
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enzyme product may serve as a ligand for setting the sensitivity of N-methyl-D-aspartate receptors under physiological conditions
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additional information
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role for D-serine in peripheral nerve transduction
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additional information
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serine racemase may negatively regulate cellular differentiation through the inhibition of sry-typeHMGbox 9, i.e.Sox9 transcriptional activity in chondrocytes
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additional information
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regulation of the D-serine content in the forebrain and in C6 glioma cells, that lack the main degerative enzyme D-amino acid oxidase, might act via mechanisms including SRR operating in alpha,beta-eliminase mode, converting D-serine to pyruvate, and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated, overview. D-serine transport mediated by ASCT2 contributes prominently to D-serine homeostasis when DAO activity is absent
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additional information
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the enzyme binds to the Golgi-localized protein Golga 3. The N-terminal of serine racemase contains residues that bind to Golga 3, which results in inhibition of ubiqitin-proteosomal serine racemase degradation
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additional information
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the enzyme catalyzes both the racemization and alpha,beta-elimination reaction of L- and D-serine to yield pyruvate and ammonia
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