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5.1.1.18: serine racemase

This is an abbreviated version!
For detailed information about serine racemase, go to the full flat file.

Word Map on EC 5.1.1.18

Reaction

L-serine
=
D-serine

Synonyms

hSR, More, RiSR, RLO149_c015450, Ser racemase, SerR, SRace, SRR, T01H8.2, Zm-SR, ZmSR

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.1 Acting on amino acids and derivatives
                5.1.1.18 serine racemase

Activating Compound

Activating Compound on EC 5.1.1.18 - serine racemase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4-dithiothreitol
-
chemical reduction with DTT increases the enzyme activity by elevating Vmax
D-serine
-
up to 5fold increase in activity
glutamate receptor interacting protein
-
glycine
hydroxylamine
activates Ser racemase activity, but inhibits Asp racemase activity
metabotropic glutamate receptor
-
i.e. mGluR5, on glia, activation mechanism of the D-serine synthesis needed for NMDA neurotransmission, overview
-
morphine
chronic administration significantly augments both serine racemase mRNA and protein expression in all brain regions and leads to slight but significant elevation in the concentration of D-serine in the cortex, striatum, and hippocampus
protein interacting with C kinase 1
-
additional information
-