5.1.1.13: aspartate racemase

This is an abbreviated version!
For detailed information about aspartate racemase, go to the full flat file.

Reaction

Synonyms

Asp racemase, Aspartate racemase, AspR, D-Asp racemase, D-Aspartate racemase, GOT1L1, LsAspR, OCC_11152, P. AspR, PhAspR, PLP-independent AspR, PTO0149, PtoAspR, pyridoxal 5'-phosphate independent aspartate racemase, pyridoxal 5'-phosphate-independent aspartate racemase, Racemase, aspartate, SbAspR, Tl-AspR

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.1 Acting on amino acids and derivatives

                5.1.1.13 aspartate racemase

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Results	in table
12	Activating Compound
1982	AA Sequence
3	Application
1	CAS Registry Number
18	Cloned(Commentary)
15	Cofactor
6	Crystallization (Commentary)
3	Disease/ Diagnostics
29	General Information
45	Inhibitors
13	kcat/KM [mM/s]
3	Ki Value [mM]
42	KM Value [mM]
5	Localization
2	Metals/Ions
13	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
100	Organism
5	Pathway
15	PDB ID
18	pH Optimum
2	pH Range
4	pH Stability
1	pI Value
21	Protein Variants
19	Purification (Commentary)
5	Reaction
3	Reaction Type
56	Reference
62	Source Tissue
12	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
17	Subunits
41	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
23	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.1.1.13 - aspartate racemase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-Nitro-5-thiocyanobenzoate

Streptococcus thermophilus

-

-

2076, 2078

5,5'-dithiobis(2-nitrobenzoate)

3 entries

5,5'-dithiobis(2-nitrobenzoic acid)

Thermococcus litoralis

H3ZNI2

35% inhibition at 1 mM

747721

alpha-methyl-DL-aspartic acid

Bifidobacterium bifidum

-

10 mM, 12% inhibition

661647

Amino-oxyacetate

Anadara broughtonii

-

complete inhibition

650892

amino-oxyacetic acid

Mus musculus

-

-

706558

ATP

2 entries

Citric acid

Pyrococcus horikoshii

O58403

competitive

695052

CoSO4

Thermococcus litoralis

H3ZNI2

36% inhibition at 1 mM

747721

CuSO4

Thermococcus litoralis

H3ZNI2

15% inhibition at 1 mM

747721

D-cycloserine

Anadara broughtonii

-

-

650892

D-penicillamine

Anadara broughtonii

-

-

650892

EDTA

Thermococcus litoralis

H3ZNI2

7% inhibition at 1 mM

747721

FeSO4

Thermococcus litoralis

H3ZNI2

43% inhibition at 1 mM

747721

GTP

Anadara broughtonii

-

non-competitive inhibition

650894

HgCl2

Bifidobacterium bifidum

-

0.1 M, complete inhibition, pH 7.0, 30°C, 30 min

661647

hydroxylamine

2 entries

iodoacetamide

Streptococcus thermophilus

-

-

2076

iodoacetate

Streptococcus thermophilus

-

-

2076

iodoacetic acid

Thermococcus litoralis

H3ZNI2

complete inhibition at 1 mM

747721

L-Cycloserine

Anadara broughtonii

-

-

650892

L-Penicillamine

Anadara broughtonii

-

-

650892

malonate

Anadara broughtonii

-

-

746669

MgSO4

Thermococcus litoralis

H3ZNI2

48% inhibition at 1 mM

747721

Mn2+

Enterococcus faecalis

-

-

2075

MnSO4

Thermococcus litoralis

H3ZNI2

18% inhibition at 1 mM

747721

N-ethylmaleimide

3 entries

NEM

2 entries

NiSO4

Thermococcus litoralis

H3ZNI2

31% inhibition at 1 mM

747721

p-chloromercuribenzoate

Streptococcus thermophilus

-

-

2076

p-chloromercuribenzoic acid

Thermococcus litoralis

H3ZNI2

36% inhibition at 1 mM

747721

PCMB

Bifidobacterium bifidum

-

0.1 M, complete inhibition, pH 7.0, 30°C, 30 min

661647

phenylhydrazine

Anadara broughtonii

-

-

650892

sodium borhydride

Anadara broughtonii

-

-

650892

thiol reagents

Streptococcus thermophilus

-

-

2076

additional information

2 entries

-

5,5'-dithiobis(2-nitrobenzoate)

Bifidobacterium bifidum

-

1 mM, complete inhibition, pH 7.0, 30°C, 30 min

661647

5,5'-dithiobis(2-nitrobenzoate)

Enterococcus faecalis

-

-

2075

5,5'-dithiobis(2-nitrobenzoate)

Streptococcus thermophilus

-

-

2076

ATP

Anadara broughtonii

-

non-competitive inhibition

650894

ATP

Anadara broughtonii

-

10 mM ATP decreases the activity to 23%

674359

hydroxylamine

Anadara broughtonii

-

complete inhibition

650892

hydroxylamine

Thermoplasma acidophilum

-

inclusion of hydroxylamine (1.0 mM and 10 mM) in the assay results in complete loss in the activity at 45°C, and also at 70°C where higher levels of activity are observed than at 45°C

726850

N-ethylmaleimide

Anadara broughtonii

-

slight inhibition

650892

N-ethylmaleimide

Thermococcus litoralis

H3ZNI2

62% inhibition at 1 mM

747721

N-ethylmaleimide

Thermoplasma acidophilum

-

-

726850

NEM

Bifidobacterium bifidum

-

1 mM, complete inhibition, pH 7.0, 30°C, 30 min

661647

NEM

Streptococcus thermophilus

-

-

2076

additional information

Streptococcus thermophilus

-

enzyme is not influenced by high concentrations of aspartate up to 500 mM

2076

-

additional information

Streptococcus thermophilus

-

enzyme is not influenced by high concentrations of aspartate up to 500 mM; no inhibition by: hydroxylamine, sodium borohydride

2078

-