5.1.1.13: aspartate racemase

This is an abbreviated version!
For detailed information about aspartate racemase, go to the full flat file.

Word Map on EC 5.1.1.13

5.1.1.13

l-aspartate

d-amino

racemization

asprs

5'-phosphate-dependent

horikoshii

scapharca

d-serine

broughtonii

d-forms

d-enantiomer

serrs

plp-dependent

d-glutamate

mirror-symmetric

food industry

analysis

Reaction

Synonyms

Asp racemase, Aspartate racemase, AspR, D-Asp racemase, D-Aspartate racemase, GOT1L1, LsAspR, OCC_11152, P. AspR, PhAspR, PLP-independent AspR, PTO0149, PtoAspR, pyridoxal 5'-phosphate independent aspartate racemase, pyridoxal 5'-phosphate-independent aspartate racemase, Racemase, aspartate, SbAspR, Tl-AspR

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.13 aspartate racemase

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Results	in table
12	Activating Compound
1982	AA Sequence
3	Application
1	CAS Registry Number
18	Cloned(Commentary)
15	Cofactor
6	Crystallization (Commentary)
3	Disease/ Diagnostics
29	General Information
45	Inhibitors
13	kcat/KM [mM/s]
3	Ki Value [mM]
42	KM Value [mM]
5	Localization
2	Metals/Ions
13	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
100	Organism
5	Pathway
15	PDB ID
18	pH Optimum
2	pH Range
4	pH Stability
1	pI Value
21	Protein Variants
19	Purification (Commentary)
5	Reaction
3	Reaction Type
56	Reference
62	Source Tissue
12	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
17	Subunits
41	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
23	Turnover Number [1/s]

Engineering

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Engineering on EC 5.1.1.13 - aspartate racemase

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P150S

Acropora millepora

JT020910

PCR-based site-directed mutagenesis, the mutant shows reduced aspartate and serine racemase activities compared to the wild-type enzyme

746724

S151P/S152F

Acropora millepora

JT020910

PCR-based site-directed mutagenesis, the mutant is inactive as aspartate racemase, but shows serine racemase activity, EC 5.1.1.18

746724

S150P/S151P/S152Y

Crassostrea gigas

K1QH67

PCR-based site-directed mutagenesis, the SSS to PPY mutation of Crassostrea AspR triple serine loop region drastically decreases the specific AspR activity to below 0.04% compared to wild-type, whereas it significantly increases the specific SerR and SDH activities by 6-13fold. The large change in the AspR activity in the mutant enzyme is caused by approximately 400fold decrease in kcat rather than by 22-32fold decrease in Km

746724

K136W

Mus musculus

the importance of lysine-136, the presumed proton donor, is highlighted by its mutation to tryptophan, which virtually abolishes racemase activity

706558

C82A

4 entries

C194A

Thermococcus litoralis

H3ZNI2