5.1.1.10: amino-acid racemase
This is an abbreviated version!
For detailed information about amino-acid racemase, go to the full flat file.
Word Map on EC 5.1.1.10
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5.1.1.10
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racemization
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pyridoxal
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synthesis
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plp-dependent
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alpha-hydrogen
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plp-binding
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buchneri
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5'-phosphate-dependent
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2-epimerase
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biotechnology
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diagnostics
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analysis
- 5.1.1.10
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racemization
- pyridoxal
- synthesis
-
plp-dependent
-
alpha-hydrogen
-
plp-binding
- buchneri
-
5'-phosphate-dependent
-
2-epimerase
- biotechnology
- diagnostics
- analysis
Reaction
Synonyms
AAR, ACL racemase, amino acid racemase, amino-acid racemase, ArgR, BAR, broad specificity amino acid racemase, broad substrate specificity amino acid racemase, broad-specificity amino acid racemase, broad-spectrum amino acid racemase, Bsar, D-amino acid racemase 1, DAR1, GkNSAAR, L-Amino acid racemase, LACBS_00576, MalY, More, N-succinylamino acid racemase, NSAR, patB, PH0138, PLP-independent amino acid racemase, Racemase, amino acid, RacX, YgeA
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Reference
Reference on EC 5.1.1.10 - amino-acid racemase
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Soda, K.; Osumi, T.
Crystalline amino acid racemase with low substrate specificity
Biochem. Biophys. Res. Commun.
35
363-368
1969
Pseudomonas putida
Soda, K.; Osumi, T.
Amino acid racemase (Pseudomonas striata)
Methods Enzymol.
17
629-636
1971
Pseudomonas putida
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Kimura, T.; Esaki, N.; Tanaka, H.; Soda, K.
Inactivation of amino acid racemase by S-(N-methylthiocarbamoyl)-D,L-cysteine
Agric. Biol. Chem.
48
383-388
1984
Pseudomonas putida
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Roise, D.; Soda, K.; Yagi, T.; Walsh, C.T.
Inactivation of the Pseudomonas striata broad specificity amino acid racemase by D and L isomers of beta-substituted alanines: kinetics, stoichiometry, active site peptide, and mechanistic studies
Biochemistry
23
5195-5201
1984
Pseudomonas putida
Badet, B.; Floss, H.G.; Walsh, C.T.
Stereochemical studies of processing of D- and L-isomers of suicide substrates by an amino acid racemase from Pseudomonas striata
J. Chem. Soc. Chem. Commun.
1984
838-840
1984
Pseudomonas putida
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Inagaki, K.; Tanizawa, K.; Tanaka, H.; Soda, K.
Purification and characterization of amino acid racemase with very broad substrate specificity from Aeromonas caviae
Agric. Biol. Chem.
51
173-180
1987
Aeromonas caviae
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Shen, S.j.; Floss, H.G.; Kumagai, H.; Yamada, H.; Esaki, N.; Soda, K.; Wasserman, S.A.; Walsh, C.
Mechanism of pyridoxal phosphate-dependent enzymatic amino-acid racemization
J. Chem. Soc. Chem. Commun.
1983
82-83
1983
Pseudomonas putida
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Lim, Y.H.; Yokoigawa, K.; Esaki, N.; Soda, K.
A new amino acid racemase with threonine alpha-epimerase activity from Pseudomonas putida: purification and characterization
J. Bacteriol.
175
4213-4217
1993
Pseudomonas putida
Lim, Y.H.; Yoshimura, T.; Kurokawa, Y.; Esaki, N.; Soda, K.
Nonstereospecific transamination catalyzed by pyridoxal phosphate-dependent amino acid racemases of broad substrate specificity
J. Biol. Chem.
273
4001-4005
1988
Pseudomonas putida
Asano, Y.; Endo, K.
Amino acid racemase with broad substrate specificity, its properties and use in phenylalanine racemization
Appl. Microbiol. Biotechnol.
29
523-527
1988
Pseudomonas putida
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Ishiwata, K.I.; Fukuhara, N.; Shimada, M.; Makiguchi, N.; Soda, K.
Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase
Biotechnol. Appl. Biochem.
12
141-149
1990
Pseudomonas putida
Reynolds, K.; Martin, J.; Shen, S.J.; Esaki, N.; Soda, K.; Floss, H.G.
Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae
J. Basic Microbiol.
31
177-188
1991
Aeromonas caviae, Pseudomonas putida
Inagaki, K.; Tanizawa, K.; Tanaka, H.; Soda, K.
Purification and properties of amino acid racemase from Aeromonas punctata subsp. caviae
Prog. Clin. Biol. Res.
144A
355-363
1984
Aeromonas caviae
Esaki, N.; Shimoi, H.; Nakajima, N.; Oshima, T.; Tanaka, H.; Soda, K.
Enzymatic in situ determination of stereospecificity of NAD-dependent dehydrogenases
J. Biol. Chem.
264
9750-9752
1989
Bacteria
Adams, E.
Amino acid racemases and epimerases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
6
479-507
1972
Pseudomonas putida
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Strisovsky, K.; Jiraskova, J.; Mikulova, A.; Rulisek, L.; Konvalinka, J.
Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity
Biochemistry
44
13091-13100
2005
Mus musculus
Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.
Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate
FEBS Lett.
535
44-48
2003
Mus musculus
Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
J. Biol. Chem.
280
1754-1763
2005
Mus musculus
Neidle, A.; Dunlop, D.S.
Allosteric regulation of mouse brain serine racemase
Neurochem. Res.
27
1719-1724
2002
Mus musculus
Nagayoshi, C.; Ishibashi, M.; Kita, Y.; Matsuoka, M.; Nishimoto, I.; Tokunaga, M.
Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag
Protein Pept. Lett.
12
487-490
2005
Homo sapiens
Kino, K.; Sato, M.; Yoneyama, M.; Kirimura, K.
Synthesis of DL-tryptophan by modified broad specificity amino acid racemase from Pseudomonas putida IFO 12996
Appl. Microbiol. Biotechnol.
73
1299-1305
2007
Pseudomonas putida
Sakai, A.; Xiang, D.F.; Xu, C.; Song, L.; Yew, W.S.; Raushel, F.M.; Gerlt, J.A.
Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids
Biochemistry
45
4455-4462
2006
Geobacillus kaustophilus
Bechtold, M.; Makart, S.; Reiss, R.; Alder, P.; Panke, S.
Model-based characterization of an amino acid racemase from Pseudomonas putida DSM 3263 for application in medium-constrained continuous processes
Biotechnol. Bioeng.
98
812-824
2007
Pseudomonas putida
Matsui, D.; Oikawa, T.; Arakawa, N.; Osumi, S.; Lausberg, F.; Staebler, N.; Freudl, R.; Eggeling, L.
A periplasmic, pyridoxal-5-phosphate-dependent amino acid racemase in Pseudomonas taetrolens
Appl. Microbiol. Biotechnol.
83
1045-1054
2009
Pseudomonas taetrolens (I0J1I6), Pseudomonas taetrolens
Pozo-Dengra, J.; Martinez-Rodriguez, S.; Contreras, L.M.; Prieto, J.; Andujar-Sanchez, M.; Clemente-Jimenez, J.M.; Las Heras-Vazquez, F.J.; Rodriguez-Vico, F.; Neira, J.L.
Structure and conformational stability of a tetrameric thermostable N-succinylamino acid racemase
Biopolymers
91
757-772
2009
Geobacillus kaustophilus
Wuerges, K.; Petrusevska-Seebach, K.; Elsner, M.P.; Luetz, S.
Enzyme-assisted physicochemical enantioseparation processes-Part III: Overcoming yield limitations by dynamic kinetic resolution of asparagine via preferential crystallization and enzymatic racemization
Biotechnol. Bioeng.
104
1235-1239
2009
Pseudomonas putida
Würges, K.; Petrusevska, K.; Serci, S.; Wilhelm, S.; Wandrey, C.; Seidel-Morgenstern, A.; Elsner, M.; Lütz, S.
Enzyme-assisted physicochemical enantioseparation processes: Part I. Production and characterization of a recombinant amino acid racemase
J. Mol. Catal. B
58
10-16
2009
Pseudomonas putida
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Pozo-Dengra, J.; Martínez-Gómez, A.; Martínez-Rodríguez, S.; Clemente-Jiménez, J.; Rodríguez-Vico, F.; Heras-Vázquez, F.
Racemization study on different N-acetylamino acids by a recombinant N-succinylamino acid racemase from Geobacillus kaustophilus CECT4264
Process Biochem.
44
835-841
2009
Geobacillus kaustophilus
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Wang, L.; Ota, N.; Romanova, E.V.; Sweedler, J.V.
A novel pyridoxal 5'-phosphate-dependent amino acid racemase in the Aplysia californica central nervous system
J. Biol. Chem.
286
13765-13774
2011
Aplysia californica
Kawakami, R.; Ohmori, T.; Sakuraba, H.; Ohshima, T.
Identification of a novel amino acid racemase from a hyperthermophilic archaeon Pyrococcus horikoshii OT-3 induced by D-amino acids
Amino Acids
47
1579-1587
2015
Pyrococcus horikoshii (O57878), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O57878)
Kawakami, R.; Sakuraba, H.; Ohmori, T.; Ohshima, T.
First characterization of an archaeal amino acid racemase with broad substrate specificity from the hyperthermophile Pyrococcus horikoshii OT-3
J. Biosci. Bioeng.
124
23-27
2017
Pyrococcus horikoshii (O57878), Pyrococcus horikoshii OT-3 (O57878)
Miyamoto, T.; Katane, M.; Saitoh, Y.; Sekine, M.; Homma, H.
Identification and characterization of novel broad-spectrum amino acid racemases from Escherichia coli and Bacillus subtilis
Amino Acids
49
1885-1894
2017
Escherichia coli (P03813), Bacillus subtilis (P32960), Bacillus subtilis 168 (P32960), Escherichia coli K-12 / MG1655 (P03813)
Payoungkiattikun, W.; Okazaki, S.; Nakano, S.; Ina, A.; H-Kittikun, A.; Asano, Y.
In silico identification for alpha-amino-epsilon-caprolactam racemases by using information on the structure and function relationship
Appl. Biochem. Biotechnol.
176
1303-1314
2015
Glutamicibacter nicotianae, Citreicella sp. SE45, Mycolicibacterium vanbaalenii (A1T974), Janibacter sp. HTCC2649 (A3TM80), Sinorhizobium medicae (A6UKD1), Brucella anthropi (A6X7I5), Brucella anthropi (Q06K28), Brucella anthropi, Mesorhizobium opportunistum (F7Y223), Sinorhizobium meliloti (H0FT96), Sinorhizobium meliloti (Q92MM4), Achromobacter obae (Q7M181), Achromobacter obae, Mesorhizobium opportunistum WSM 2075 (F7Y223), Sinorhizobium meliloti CCNWSX0020 (H0FT96), Sinorhizobium medicae WSM 419 (A6UKD1), Mycolicibacterium vanbaalenii PYR-1 (A1T974), Glutamicibacter nicotianae NCIMB 41126, Brucella anthropi IA / NCBIMB41129 (Q06K28), Brucella anthropi ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168 (A6X7I5)
Wang, X.; Yang, L.; Cao, W.; Ying, H.; Chen, K.; Ouyang, P.
Efficient production of enantiopure D-lysine from L-lysine by a two-enzyme cascade system
Catalysts
6
168-178
2016
Lacticaseibacillus paracasei, Lacticaseibacillus paracasei ATCC 334
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Kato, S.; Oikawa, T.
A novel bifunctional amino acid racemase with multiple substrate specificity, malY from Lactobacillus sakei LT-13 Genome-based identification and enzymological characterization
Front. Microbiol.
9
403
2018
Latilactobacillus sakei (A0A223K4L6), Latilactobacillus sakei LT-13 (A0A223K4L6)
Kuan, Y.; Thiruvengadam, V.; Lin, J.; Liu, J.; Chen, T.; Wu, H.; Wang, W.; Chen, L.
Broad-specificity amino acid racemase, a novel non-antibiotic selectable marker for transgenic plants
Plant Biotechnol. Rep.
12
27-38
2018
Pseudomonas putida, Pseudomonas putida DSM 84
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