4.99.1.9: coproporphyrin ferrochelatase

This is an abbreviated version!
For detailed information about coproporphyrin ferrochelatase, go to the full flat file.

Reaction

Synonyms

hemH

ECTree

     4 Lyases

         4.99 Other lyases

             4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses

                4.99.1.9 coproporphyrin ferrochelatase

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Results	in table
9312	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
6	General Information
2	Inhibitors
2	kcat/KM [mM/s]
5	KM Value [mM]
2	Localization
5	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
113	Organism
4	Pathway
1	pH Optimum
1	pH Range
7	Protein Variants
1	Purification (Commentary)
1	Reaction
11	Reference
1	Storage Stability
16	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Engineering

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Engineering on EC 4.99.1.9 - coproporphyrin ferrochelatase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E264Q

Bacillus subtilis

P32396

21% of wild-type activity

678312

E264V

Bacillus subtilis

P32396

less than 1% of wild-type activity

678312

H183A

Bacillus subtilis

P32396

less than 1% of wild-type activity

678312

H183C

Bacillus subtilis

P32396

less than 1% of wild-type activity

678312

H88A

Bacillus subtilis

P32396

5% of wild-type activity

678312

K87A

Bacillus subtilis

P32396

92% of wild-type activity

678312

Y13F

Bacillus subtilis

P32396

71% of wild-type activity

678312