4.99.1.2: alkylmercury lyase
This is an abbreviated version!
For detailed information about alkylmercury lyase, go to the full flat file.
Word Map on EC 4.99.1.2
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4.99.1.2
-
methylmercury
-
mercury-resistant
-
protonolysis
-
phytoremediation
-
phenylmercury
-
hg-resistant
-
environmental protection
-
biomagnifies
-
mercury-contaminated
-
biotechnology
- 4.99.1.2
- methylmercury
-
mercury-resistant
-
protonolysis
-
phytoremediation
- phenylmercury
-
hg-resistant
- environmental protection
-
biomagnifies
-
mercury-contaminated
- biotechnology
Reaction
Synonyms
alkylmercury mercuric-lyase, lyase, alkylmercury, merB, MerB1, MerB2, MerB3, organomercurial lyase, organomercury lyase
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Reference on EC 4.99.1.2 - alkylmercury lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walsh, C.; Begley, T.; Walts, A.
Bacterial organomercurial lyase: Mechanistic studies on a protonolytic organomercurial cleaving enzyme in mercurial detoxification
Stereochem. Org. Bioorg. Transform. (Proc. Workshop, Conf. Hoechst,17th Meeting, Bartmann, W. , Sharpless, K. , eds. )
17
73-83
1986
Escherichia coli, Escherichia coli overproducing
-
Walts, A.; Walsh, C.T.
Bacterial organomercurial lyase: Novel enzymatic protonolysis of organostannanes
J. Am. Chem. Soc.
110
1950-1953
1988
Escherichia coli
-
Begley, T.P.; Walts, A.E.; Walsh, C.T.
Mechanistic studies of a protonolytic organomercurial cleaving enzyme: bacterial organomercurial lyase
Biochemistry
25
7192-7200
1986
Escherichia coli
Begley, T.P.; Walts, A.E.; Walsh, C.T.
Bacterial organomercurial lyase: overproduction, isolation, and characterization
Biochemistry
25
7186-7192
1986
Escherichia coli
Tezuka, T.; Tonomura, K.
Purification and properties of an enzyme catalyzing the splitting of carbon-mercury linkages from mercury-resistant Pseudomonas K-62 strain. I. Splitting enzyme 1
J. Biochem.
80
79-87
1976
Pseudomonas sp.
Griffin, H.G.; Foster, T.J.; Silver, S.; Misra, T.K.
Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358
Proc. Natl. Acad. Sci. USA
84
3112-3116
1987
Escherichia coli
Tezuka, T.; Takasaki, Y.
Biodegradation of phenylmercuric acetate by organomercury-resistant Penicillum sp. MR-2
Agric. Biol. Chem.
52
3183-3185
1988
Penicillium sp., Penicillium sp. MR-2
-
Izaki, K.; Aoki, T.; Takahashi, H.
Degradation of organomercurials in Becillus cereus
Agric. Biol. Chem.
49
2413
1985
Bacillus cereus
-
Laddaga, R.A.; Chu, L.; Misra, T.K.; Silver, S.
Nucleotide sequence and expression of the mercurial-resistance operon from Staphylococcus aureus plasmid pI258
Proc. Natl. Acad. Sci. USA
84
5106-5110
1987
Staphylococcus aureus, Serratia sp.
Gachhui, R.; Chaudhuri, J.; Ray, S.; Pahan, K.; Mandal, A.
Studies on mercury-detoxicating enzymes from a broad-spectrum mercury-resistant strain of Flavobacterium rigense
Folia Microbiol. (Praha)
42
337-343
1997
Flavobacterium rigense
Pahan, K.; Gachhui, R.; Ray, S.; Chaudhuri, J.; Mandal, A.
A PMA degrading constitutive organomercurial lyase in a broad-spectrum mercury resistant Bacillus pasteurii strain DR2
Indian J. Exp. Biol.
29
1147-1149
1991
Sporosarcina pasteurii
Pahan, K.; Ray, S.; Gachhui, R.; Chaudhuri, J.; Mandal, A.
Effect of thiol compounds and flavins on mercury and organomercurial degrading enzymes in mercury resistant aquatic bacteria
Bull. Environ. Contam. Toxicol.
44
216-223
1990
Alcaligenes faecalis, Sporosarcina pasteurii
Pahan, K.; Ghosh, D.K.; Ray, S.; Gachhui, R.; Chaudhuri, J.; Mandal, A.
Mercury and organomercurial degrading enzymes in a broad-spectrum Hg-resistant strain of Bacillus pasteurii
Bull. Environ. Contam. Toxicol.
52
582-589
1994
Sporosarcina pasteurii
Pitts, K.E.; Summers, A.O.
The roles of thiols in the bacterial organomercurial lyase (MerB)
Biochemistry
41
10287-10296
2002
Serratia marcescens
Huang, C.C.; Narita, M.; Yamagata, T.; Endo, G.
Identification of three merB genes and characterization of a broad-spectrum mercury resistance module encoded by a class II transposon of Bacillus megaterium strain MB1
Gene
239
361-366
1999
Priestia megaterium (Q7DJN2), Priestia megaterium
Bizily, S.P.; Rugh, C.L.; Meagher, R.B.
Phytodetoxification of hazardous organomercurials by genetically engineered plants
Nat. Biotechnol.
18
213-217
2000
Escherichia coli
Bizily, S.P.; Kim, T.; Kandasamy, M.K.; Meagher, R.B.
Subcellular targeting of methylmercury lyase enhances its specific activity for organic mercury detoxification in plants
Plant Physiol.
131
463-471
2003
Escherichia coli
Benison, G.C.; Di Lello, P.; Shokes, J.E.; Cosper, N.J.; Scott, R.A.; Legault, P.; Omichinski, J.G.
A stable mercury-containing complex of the organomercurial lyase MerB: catalysis, product release, and direct transfer to MerA
Biochemistry
43
8333-8345
2004
Escherichia coli
Murtaza, I.; Dutt, A.; Mushtaq, D.; Ali, A.
Molecular cloning and genetic analysis of functional merB gene from indian isolates of Escherichia coli
Curr. Microbiol.
51
297-302
2005
Escherichia coli (Q9S4I1), Escherichia coli (Q9S4I2), Escherichia coli (Q9S4I3), Escherichia coli
Taubner, L.M.; McGuirl, M.A.; Dooley, D.M.; Copie, V.
Structural studies of Apo NosL, an accessory protein of the nitrous oxide reductase system: insights from structural homology with MerB, a mercury resistance protein
Biochemistry
45
12240-12252
2006
Achromobacter cycloclastes
Che, D.; Meagher, R.B.; Rugh, C.L.; Kim, T.; Heaton, A.C.; Merkle, S.A.
Expression of organomercurial lyase in eastern cottonwood enhances organomercury resistance
In Vitro Cell. Dev. Biol. Plant
42
228-234
2006
Populus deltoides
-
Melnick, J.G.; Parkin, G.
Cleaving mercury-alkyl bonds: a functional model for mercury detoxification by MerB
Science
317
225-227
2007
Escherichia coli, Escherichia coli R831b
Kotrba, P.; Najmanova, J.; Macek, T.; Ruml, T.; Mackova, M.
Genetically modified plants in phytoremediation of heavy metal and metalloid soil and sediment pollution
Biotechnol. Adv.
27
799-810
2009
Escherichia coli, Escherichia coli Tn21
Lafrance-Vanasse, J.; Lefebvre, M.; Di Lello, P.; Sygusch, J.; Omichinski, J.G.
Crystal structures of the organomercurial lyase MerB in its free and mercury-bound forms: insights into the mechanism of methylmercury degradation
J. Biol. Chem.
284
938-944
2009
Escherichia coli (P77072)
Nagata, T.; Morita, H.; Akizawa, T.; Pan-Hou, H.
Development of a transgenic tobacco plant for phytoremediation of methylmercury pollution
Appl. Microbiol. Biotechnol.
87
781-786
2010
Pseudomonas sp. K-62 (O07303)
Parks, J.M.; Guo, H.; Momany, C.; Liang, L.; Miller, S.M.; Summers, A.O.; Smith, J.C.
Mechanism of Hg-C protonolysis in the organomercurial lyase MerB
J. Am. Chem. Soc.
131
13278-13285
2009
Escherichia coli (P77072)
Nagata, T.; Muraoka, T.; Kiyonoa, M.; Pan-Hou, H.
Development of a luminescence-based biosensor for detection of methylmercury
J. Toxicol. Sci.
35
231-234
2010
Pseudomonas sp. K-62 (O07303)
Li, X.; Liao, R.Z.; Zhou, W.; Chen, G.
DFT studies of the degradation mechanism of methyl mercury activated by a sulfur-rich ligand
Phys. Chem. Chem. Phys.
12
3961-3971
2010
Escherichia coli (P77072)
Hong, B.; Nauss, R.; Harwood, I.M.; Miller, S.M.
Direct measurement of mercury(II) removal from organomercurial lyase (MerB) by tryptophan fluorescence: NmerA domain of coevolved gamma-proteobacterial mercuric ion reductase (MerA) is more efficient than MerA catalytic core or glutathione
Biochemistry
49
8187-8196
2010
Serratia marcescens (P08664)
Chien, M.F.; Narita, M.; Lin, K.H.; Matsui, K.; Huang, C.C.; Endo, G.
Organomercurials removal by heterogeneous merB genes harboring bacterial strains
J. Biosci. Bioeng.
110
94-98
2010
Staphylococcus aureus, no activity in Bacillus subtilis, Pseudomonas sp., Bacillus cereus (P16172), Priestia megaterium (Q9RHR0), Bacillus cereus RC607 (P16172), Priestia megaterium MB1 (Q9RHR0), no activity in Bacillus subtilis 168, Staphylococcus aureus RN23
Sone, Y.; Mochizuki, Y.; Koizawa, K.; Nakamura, R.; Pan-Hou, H.; Itoh, T.; Kiyono, M.
Mercurial-resistance determinants in Pseudomonas strain K-62 plasmid pMR68
AMB Express
3
41
2013
Pseudomonas sp. (I2FG55)
Mathema, V.B.; Thakuri, B.C.; Sillanpaeae, M.
Bacterial mer operon-mediated detoxification of mercurial compounds: a short review
Arch. Microbiol.
193
837-844
2011
Staphylococcus aureus
Wahba, H.M.; Lecoq, L.; Stevenson, M.; Mansour, A.; Cappadocia, L.; Lafrance-Vanasse, J.; Wilkinson, K.J.; Sygusch, J.; Wilcox, D.E.; Omichinski, J.G.
Structural and biochemical characterization of a copper-binding mutant of the organomercurial lyase MerB insight into the key role of the active site aspartic acid in Hg-carbon bond cleavage and metal binding specificity
Biochemistry
55
1070-1081
2016
Escherichia coli (P77072), Escherichia coli, Priestia megaterium (Q7DJN2)
Wahba, H.M.; Stevenson, M.J.; Mansour, A.; Sygusch, J.; Wilcox, D.E.; Omichinski, J.G.
Structural and biochemical characterization of organotin and organolead compounds binding to the organomercurial lyase MerB provide new insights into its mechanism of carbon-metal bond cleavage
J. Am. Chem. Soc.
139
910-921
2017
Escherichia coli (P77072), Escherichia coli
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