4.6.1.6: cytidylate cyclase

This is an abbreviated version!
For detailed information about cytidylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.6

4.6.1.6

cytidine

5'-triphosphate

gtp

3',5'-monophosphate

triton

pyrophosphate

immunoassay

ignarro

radiometric

detergent

bombardment

toxin

adenylate

Reaction

Synonyms

3',5'-cyclic-CMP synthase, CyaA, cytidyl cyclase, cytidylyl cyclase, Edema factor

ECTree

4 Lyases

4.6 Phosphorus-oxygen lyases

4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

4.6.1.6 cytidylate cyclase

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Results	in table
2	Activating Compound
4	AA Sequence
1	CAS Registry Number
21	Inhibitors
3	kcat/KM [mM/s]
13	Ki Value [mM]
6	KM Value [mM]
6	Localization
8	Metals/Ions
9	Natural Substrates/ Products (Substrates)
185	Organism
4	pH Optimum
3	pH Range
1	Reaction
1	Reaction Type
14	Reference
35	Source Tissue
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.6.1.6 - cytidylate cyclase

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CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)

In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.