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4.6.1.2: guanylate cyclase

This is an abbreviated version!
For detailed information about guanylate cyclase, go to the full flat file.

Word Map on EC 4.6.1.2

Reaction

GTP
=
3',5'-cyclic GMP
 +
diphosphate

Synonyms

alpha1 sGC, alpha1 soluble guanylyl cyclase, alpha1beta1 guanylyl cyclase, alpha1beta1 sGC, ANF-RGC, ANPRA, ANPRB, atrial natriuretic factor receptor guanylate cyclase, Atrial natriuretic peptide A-type receptor, Atrial natriuretic peptide B-type receptor, atrial natriuretic peptide receptor 2, BERhGC, BR1-GC, brassinosteroid receptor 1, CaRhGC, CNP-sensitive guanyly cyclase, CNP-sensitive guanylyl cyclase, CsGC-YO1, GC-A, GC-A receptor, GC-B, GC-C, GC-D, GC-G, GC1, GC2, GCA, GCC, gcy-18, gcy-23, GCY-35, gcy-8, GTP-pyrophosphate liase cyclizing, GTP-pyrophosphate lyase, guanyl cyclase, guanyl cyclase B, Guanylate cyclase, guanylate cyclase 1, guanylate cyclase 2, Guanylate cyclase 2D, retinal, Guanylate cyclase 2E, Guanylate cyclase 2F, retinal, guanylate cyclase A, guanylate cyclase B, guanylate cyclase C, Guanylate cyclase, olfactory, guanylyl cyclase, guanylyl cyclase A, guanylyl cyclase B, guanylyl cyclase C, guanylyl cyclase C receptor, guanylyl cyclase-A, guanylyl cyclase-A receptor, guanylyl cyclase-C, guanylyl cyclase-D, guanylyl cyclase-G, Gyc-88E, Gyc-89Da, Gyc-89Db, Gyca-99B, Gycb-100B, H-NOX, hSTAR, Intestinal guanylate cyclase, KSGC, L1 H-NOX, L2 H-NOX, membrane bound guanylate cyclase, membrane bound guanylyl cyclase, membrane guanylate cyclase, membrane guanylyl cyclase receptor, membrane-bound GC, membrane-bound guanylate cyclase, membrane-bound guanylyl cyclase, mGc, More, natriuretic peptide-activated guanylate cyclase, nitric oxid sensitive guanylyl cyclase, nitric oxide sensitive guanylyl cyclase, nitric oxide sensitive-guanylyl cyclase, nitric oxide-sensitive guanylate cyclase, nitric-oxide-sensitive guanylyl cyclase, NO receptor, NO receptor soluble guanylyl cyclase, NO sensitive guanylyl cyclase, NO- and haem-independent sGC, NO- and haem-independent soluble guanylate cyclase, NO-GC, NO-GC1, NO-GC2, NO-independent, heme-dependent soluble guanylate cyclase, NO-sensitive GC, NO-sensitive guanylyl cyclase, NO-sGC, NOGC1, NOsGC, NP-GC, NPR A, NPR-A, NPR-B, NPR1, NPR2, ONE-GC, ONE-GC membrane guanylate cyclase, Pac2, Pac3, particulate GC, particulate guanylate cyclase, particulate guanylyl cyclase, PepR1-GC, peptide hormone receptor guanylyl cyclase-C, PGC, photoreceptor guanylyl cyclase, phytosulfokine receptor, PSK receptor, PSKR1, ratGC, receptor guanylyl cyclase, receptor-type guanylyl cyclase, RET-GC1, retGC, RetGC1, RetGC2, retinal guanylate cyclase, retinal guanylyl cyclase, retinal membrane guanylyl cyclase, rGC, rhodopsin-guanylyl cyclase, Rod outer segment membrane guanylate cyclase, rod outer segment membrane guanylate cyclase type 1, ROS-GC, ROS-GC1, ROS-GC2, sGC, sGC alpha2 inhibitory isoform, sGC alpha2 isoform, sGCalpha1, sGCalpha2beta1, sGCbeta1, sGCbeta3, soluble GC, soluble guanylate cyclase, soluble guanylate cyclase alpha1, soluble guanylate cyclase alpha2, soluble guanylyl cyclase, SONO, STA, STA receptor, Tar4 protein

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.2 guanylate cyclase

Specific Activity

Specific Activity on EC 4.6.1.2 - guanylate cyclase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00000045
activity in cotyledons
0.00000048
activity in seedlings
0.0056
basal sGC activity
0.0096
-
recombinant intracellular domain of GCC
0.022
purified recombinant sGC
0.034
-
basal activity in the absence of NO
0.047
-
mutant enzyme D102N, at pH 8.5 and 33°C, in the absence of any stimulator
0.073
-
mutant enzyme D102E, at pH 8.5 and 33°C, in the absence of any stimulator
0.087
-
mutant enzyme D102N, at pH 8.5 and 33°C, in the presence of 0.1 mM protoporphyrin-IX
0.108
-
mutant enzyme F120A, at pH 8.5 and 33°C, in the presence of 0.1 mM protoporphyrin-IX
0.11
-
-
0.12
-
basal activity
0.128
-
mutant enzyme D102E, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.152
-
mutant enzyme D102E, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.16
-
mutant enzyme D102A, at pH 8.5 and 33°C, in the presence of 0.1 mM protoporphyrin-IX
0.161
-
mutant enzyme D102A, at pH 8.5 and 33°C, in the absence of any stimulator
0.168
-
mutant enzyme D102E, at pH 8.5 and 33°C, in the presence of 0.1 mM protoporphyrin-IX
0.169
-
mutant enzyme F120A, at pH 8.5 and 33°C, in the absence of any stimulator
0.172
-
mutant enzyme F120A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.202
-
mutant enzyme D102N, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.205
-
-
0.229
0.231
-
mutant enzyme F120A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol and 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.276
-
with Mn2+
0.278
-
mutant enzyme F120A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.287
-
-
0.29
-
pulmonary artery homogenate in absence of NO
0.292
-
mutant enzyme D102E, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol and 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.354
-
mutant enzyme D102A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.431
-
wild type enzyme, at pH 8.5 and 33°C, in the presence of 0.1 mM protoporphyrin-IX
0.53
-
pulmonary artery homogenate after 24 h of treatment with NO
0.662
-
mutant enzyme D102A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol and 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
0.94
-
-
1.063
-
mutant enzyme D102N, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol and 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
1.232
-
mutant enzyme D102A, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
1.33
purified recombinant sGC in presence of 3-ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene
1.38
-
pulmonary artery homogenate after 2 h of treatment with NO
1.43
-
wild type enzyme, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
12.1
-
in the presence of 0.1 mM N-(beta-D-glucopyranosyl-N2-acetyl-S-nitroso-D,L-penicillaminamide) and YC-1
15.7
-
with Mg2+
16.81
-
pH 7.4, 37°C
17.5
-
-
2.96
-
in the presence of 0.1 mM 2,2-diethyl-1-nitroso-oxyhydrazine as NO source
22.1
-
NO-stimulated sGC
3.25
sodium nitroprusside activated sGC activity
3.328
-
wild type enzyme, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
3.402
-
wild type enzyme, at pH 8.5 and 33°C, in the presence of 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol and 0.1 mM 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
38
-
-
4.03
-
-
5.6
-
Fe(II)-unligated Gyc-88E(1-597)
70 - 110
-
-
8.5
-
with Mn2+
9.1
-
in the presence of 0.1 mM N-(beta-D-glucopyranosyl-N2-acetyl-S-nitroso-D,L-penicillaminamide)
additional information