4.6.1.15: FAD-AMP lyase (cyclizing)

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For detailed information about FAD-AMP lyase (cyclizing), go to the full flat file.

Reaction

Synonyms

dAK, Flavine-adenine-dinucleotide cyclase, FMN cyclase, FMN cyclase/dha kinase, Rivoflavin cyclic phosphate synthase, TKFC, triokinase/FMN cyclase

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.15 FAD-AMP lyase (cyclizing)

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Systematic Name

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Systematic Name on EC 4.6.1.15 - FAD-AMP lyase (cyclizing)

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SYSTEMATIC NAME

IUBMB Comments

FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming)

Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN.