4.6.1.14: glycosylphosphatidylinositol diacylglycerol-lyase

This is an abbreviated version!
For detailed information about glycosylphosphatidylinositol diacylglycerol-lyase, go to the full flat file.

Reaction

Synonyms

(glycosyl)phosphatidylinositol-specific phospholipase C, EC 3.1.4.47, GDE3, glycan-phosphatidylinositol-specific phospholipase C, glycosyl inositol phospholipid anchor-hydrolyzing enzyme, glycosylphosphatidylinositol phospholipase C, glycosylphosphatidylinositol-phospholipase C, glycosylphosphatidylinositol-specific phospholipase C, glycosylphosphatidylinositol-specific phospholipase D, GPI-PC, GPI-phosphatidylinositol-phospholipase C, GPI-phospholipase C, GPI-phospholipase C polypeptide, GPI-PLC, GPI-PLC enzyme, GPI-PLCp, GPI-PLD, GPI-specific phospholipase C, phospholipase C, glycosylphosphatidylinositol, variant-surface-glycoprotein phospholipase C, variant-surface-glycoprotein-1,2-didecanoyl-sn-phosphatidylinositol inositolphosphohydrolase, VSG-lipase

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase

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15	Activating Compound
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13	Disease/ Diagnostics
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7	General Information
3	General Stability
53	Inhibitors
1	Ki Value [mM]
10	KM Value [mM]
20	Localization
5	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
64	Organism
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58	Protein Variants
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37	Reference
14	Source Tissue
11	Specific Activity [micromol/min/mg]
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63	Substrates and Products (Substrate)
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48	Synonyms
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2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.6.1.14 - glycosylphosphatidylinositol diacylglycerol-lyase

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SYSTEMATIC NAME

IUBMB Comments

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]

This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide (see Lip-1.4 and Lip-1.5 for definition). The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol blocks action of this enzyme. It is not identical with EC 3.1.4.50, glycosylphosphatidylinositol phospholipase D.